Prognostic significance of PD-L1 and TLR5 expression in peripheral T-cell lymphomas

2019 ◽  
Vol 60 (11) ◽  
pp. 2599-2601
Author(s):  
Saurabh Zanwar ◽  
Stephen M. Ansell
Keyword(s):  
T Cell ◽  
Prognostic Significance ◽  
T Cell Lymphomas ◽  
Peripheral T Cell Lymphomas ◽  
Tlr5 Expression

scholarly journals Prognostic Significance of FDG-PET/CT on Determining Upfront Autologous Stem Cell Transplantation for the Treatment of Peripheral T Cell Lymphomas

Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 1632-1632
Author(s):  
Seo-Yeon Ahn ◽  
Seung-Yeon Jung ◽  
Sung-Hoon Jung ◽  
Jae-Sook Ahn ◽  
Je-Jung Lee ◽  
...  
Keyword(s):  
T Cell ◽  
Fdg Pet ◽  
Prognostic Significance ◽  
Primary Treatment ◽  
Transplant Patients ◽  
Deauville Score ◽  
T Cell Lymphomas ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Peripheral T Cell Lymphomas

Abstract Purpose: The clinical role of 18F-fluorodeoxyglucose (FDG)-positron emission tomography-computed tomography (PET/CT) in performing upfront high-dose chemotherapy followed by autologous stem cell transplantation (ASCT) remains unclear in peripheral T cell lymphomas (PTCLs). This study investigated the prognostic relevance of interim and final FDG-PET/CT in predicting the outcome of upfront ASCT for the treatment of PTCLs. Method: The study conducted newly diagnosed 96 patients with PTCLs who aged under 65 years between January 2005 and December 2016 from two independent institutions. For making a comparison of clinical outcome between transplant and non-transplant patients according to interim or final FDG- PET/CT, 37 transplanted and 59 non-transplanted patients with the same populations were evaluated as a comparative group (non-ASCT). The enrolled patients were treated with mainly anthracycline-based chemotherapy except patients with NK/T cell lymphoma who were treated with non-anthracycline-based. If achieved complete or partial remission after primary treatment, patients proceeded to upfront ASCT. FDG-PET/CT was performed at the time of diagnosis, interim, and after primary treatment. The response of interim or final FDG-PET/CT was analyzed by visual assessment using Deauville five-point scale (5-PS). Results: The characteristics of transplant patients were similar to non-transplant patients except two features (IPI score, CT response). Final FDG-PET/CT response (P<0.001, Hazard ratio (HR) 3.51), CT response (P<0.001, HR 2.11) and age (P=0.005, HR 1.07) were significant prognostic factors of progression-free survival (PFS) in transplant patients on multivariate analysis. In non-ASCT patients, final FDG-PET/CT response (P<0.001, HR 9.65), prognostic index for T-cell lymphomas (PITs) score (P=0.001, HR 5.24), and CT response (P<0.001, HR 2.34) were prognostic for PFS. After a median follow-up of 60.8 months, 5-year PFS rates of ASCT and non-ASCT patients according to interim FDG-PET/CT response were 75.5 vs 74.5% of Deauville score 1-2, 20% vs 22.2% of Deauville score 3 and 33.3% vs 42.2% of Deauville score 4, respectively (P=0.092, P=0.005; Figure 1A, 1C). 5-year PFS rates according to final FDG-PET/CT response of ASCT and non-ASCT patients were 70.2% vs 80.5% of Deauville score 1-2, 22.2% vs 25% of Deauville score 3 and 0% vs 0% of Deauville score 4, respectively (P<0.001, P<0.001; Figure 1B, 1D). Conclusion: Final FDG-PET/CT response based on Deauville 5-PS had prognostic significance on the treatment outcome of PTCLs regardless of upfront ASCT. However, patients with ≥ 3 of Deauville score assessed by interim or final FDG-PET/CT had poor prognosis even though performing upfront ASCT. Disclosures No relevant conflicts of interest to declare.

Prognosis and Primary Therapy in Peripheral T-Cell Lymphomas

Hematology ◽  
2008 ◽  
Vol 2008 (1) ◽  
pp. 280-288 ◽  
Author(s):  
Kerry J. Savage
Keyword(s):  
T Cell ◽  
Prognostic Significance ◽  
B Cell Lymphoma ◽  
Large Cell ◽  
Classification Systems ◽  
Cell Phenotype ◽  
Primary Therapy ◽  
T Cell Lymphomas ◽  
Alk Positive ◽  
Peripheral T Cell Lymphomas

AbstractPeripheral NK/T-cell neoplasms are an uncommon group of diseases that show distinct racial and geographic variation. The prognostic significance of the T-cell phenotype has been clearly defined in recent studies by using modern lymphoma classification systems. However, within this heterogenous group of neoplasms, some have a more favorable prognosis, such as ALK-positive anaplastic large-cell leukemia (ALCL) and primary cutaneous ALCL, and some have ultimately fatal courses with standard chemotherapy programs (e.g., hepatosplenic γδ T-cell lymphomas). Further, unlike the benefits observed with CHOP chemotherapy in the treatment of diffuse large B-cell lymphoma (DLBCL), peripheral T-cell lymphomas (PTCL), other than ALK-positive ALCL, are relatively chemoresistant to this regimen. Given disease rarity and biological heterogeneity, advances in diagnosis, prognosis and treatment have lagged behind DLBCL. Recently, however, studies are emerging that focus specifically on PTCLs with the ultimate goal of better understanding disease biology and developing more effective therapies.

scholarly journals Prognostic significance of Twist, ZEB1 and Slug in peripheral T-cell lymphomas

Hematology ◽  
2020 ◽  
Vol 25 (1) ◽  
pp. 241-246 ◽  
Author(s):  
Pyry M. Uotila ◽  
Siria A. Lemma ◽  
Kirsi-Maria Haapasaari ◽  
Katja Porvari ◽  
Sini Skarp ◽  
...  
Keyword(s):  
T Cell ◽  
Prognostic Significance ◽  
T Cell Lymphomas ◽  
Peripheral T Cell Lymphomas

scholarly journals Derivation and validation of a lipid-covered prognostic model for mature T-cell lymphomas

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tiange Lu ◽  
Lei Shi ◽  
Guanggang Shi ◽  
Yiqing Cai ◽  
Shunfeng Hu ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
T Cell ◽  
Scoring System ◽  
Serum Lipid ◽  
Prognostic Model ◽  
Validation Cohort ◽  
Univariate Analysis ◽  
Prognostic Significance ◽  
Cox Regression Analysis ◽  
T Cell Lymphomas

Abstract Background Mature T-cell lymphomas (MTCLs), a group of diseases with high aggressiveness and vulnerable prognosis, lack for the accurate prognostic stratification systems at present. Novel prognostic markers and models are urgently demanded. Aberrant lipid metabolism is closely related to the tumor progression but its prognostic significance in MTCLs remains unexplored. This study aims to investigate the relationship between dysregulated lipid metabolism and survival prognosis of MTCLs and establish a novel and well-performed prognostic scoring system for MTCL patients. Methods A total of 173 treatment-naive patients were enrolled in this study. Univariate and multivariate Cox regression analysis were performed to assess the prognostic significance of serum lipid profiles and screen out independent prognostic factors, which constituted a novel prognostic model for MTCLs. The performance of the novel model was assessed in the training and validation cohort, respectively, by examining its calibration, discrimination and clinical utility. Results Among the 173 included patients, 115 patients (01/2006–12/2016) constituted the training cohort and 58 patients (01/2017–06/2020) formed the validation cohort. Univariate analysis revealed declined total cholesterol (TC, P = 0.000), high-density lipoprotein cholesterol (HDL-C, P = 0.000) and increased triglycerides (TG, P = 0.000) correlated to inferior survival outcomes. Multivariate analysis revealed extranodal involved sites ≥ 2 (hazard ratio [HR]: 2.439; P = 0.036), β2-MG ≥ 3 mg/L (HR: 4.165; P = 0.003) and TC < 3.58 mmol/L (HR: 3.338; P = 0.000) were independent predictors. Subsequently, a novel prognostic model, EnBC score, was constructed with these three factors. Harrell’s C-index of the model in the training and validation cohort was 0.840 (95% CI 0.810–0.870) and 0.882 (95% CI 0.822–0.942), respectively, with well-fitted calibration curves. The model divided patients into four risk groups with distinct OS [median OS: not available (NA) vs. NA vs. 14.0 vs. 4.0 months, P < 0.0001] and PFS (median PFS: 84.0 vs. 19.0 vs. 8.0 vs. 1.5 months, P < 0.0001). Time-dependent receiver operating characteristic curve and decision curve analysis  further revealed that EnBC score provided higher diagnostic capacity and clinical benefit, compared with International Prognostic Index (IPI). Conclusion Firstly, abnormal serum lipid metabolism was demonstrated significantly related to the survival of MTCL patients. Furthermore, a lipid-covered prognostic scoring system was established and performed well in stratifying patients with MTCLs.

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