The R&D stochastic component within the ‘sailing-ship effect’

Author(s):  
Giovanni Filatrella ◽  
Nicola De Liso
1958 ◽  
Vol 18 (4) ◽  
pp. 556-573 ◽  
Author(s):  
Max E. Fletcher

The opening of the Suez Canal took place in a century crowded revolutionary changes in the shipping world. In sharp contrast to the slow pace of change and development in the preceding era, major changes occurred in almost every sector of the shipping industry in the nineteenth century. While many of the new departures can be explained, at least in part, by the application of the techniques of the Industrial Revolution to shipping, the opening of Suez went far to accelerate and give direction to these changes. The canal significantly altered shipbuilding techniques and practices and contributed to the precipitous decline in the importance of the sailing ship as a major world carrier. Suez helped to bring about die realignment and relative decline of the European entrepot trade. And the new channel led to significant shifts in the patterns of Eastern and Australasian trade.


2019 ◽  
Author(s):  
K Ouchi ◽  
T Omiya

When a sailing ship which has large rigid wing sails such as the Wind Challenger Sail runs in a sufficiently windy sea, the thrust by sails is utilized to not only drive the ship at the proper speed but also to rotate an underwater turbine at significant speed and torque. The turbine generates electricity which is used for the electrolysis of water to generate hydrogen. The hydrogen is stored using toluene in the form of methylcyclohexane (MCH), which is in liquid form under normal temperature and pressure. MCH is stored in the ship's tank as hydrogen fuel. In the case of weak winds when the sails cannot generate sufficient thrust, using the hydrogen generated by the dehydrogenation device, the fuel cell works and supplies electricity to the electric motor propeller for the ship's propulsion. Thus, the ship can run at a constant speed regardless of wind speed and direction.


2016 ◽  
Vol 3 (12) ◽  
pp. 160578 ◽  
Author(s):  
Mohammad Soltani ◽  
Abhyudai Singh

Expression of many genes varies as a cell transitions through different cell-cycle stages. How coupling between stochastic expression and cell cycle impacts cell-to-cell variability (noise) in the level of protein is not well understood. We analyse a model where a stable protein is synthesized in random bursts, and the frequency with which bursts occur varies within the cell cycle. Formulae quantifying the extent of fluctuations in the protein copy number are derived and decomposed into components arising from the cell cycle and stochastic processes. The latter stochastic component represents contributions from bursty expression and errors incurred during partitioning of molecules between daughter cells. These formulae reveal an interesting trade-off: cell-cycle dependencies that amplify the noise contribution from bursty expression also attenuate the contribution from partitioning errors. We investigate the existence of optimum strategies for coupling expression to the cell cycle that minimize the stochastic component. Intriguingly, results show that a zero production rate throughout the cell cycle, with expression only occurring just before cell division, minimizes noise from bursty expression for a fixed mean protein level. By contrast, the optimal strategy in the case of partitioning errors is to make the protein just after cell division. We provide examples of regulatory proteins that are expressed only towards the end of the cell cycle, and argue that such strategies enhance robustness of cell-cycle decisions to the intrinsic stochasticity of gene expression.


Author(s):  
A. D. Cliff ◽  
M.R. Smallman-Raynor ◽  
P. Haggett ◽  
D.F. Stroup ◽  
S.B. Thacker

The human population of the earth took the whole of its existence until 1800 to build to 1 billion. By 2000 it had exceeded 6 billion, more than doubling in the twentieth century alone. In 1800, the time taken to navigate the globe by sailing ship was about a year. Today, no two cities served by commercial aircraft are more than a couple of days apart. Since this is less than most disease incubation times, infected people can travel undetected—a concern noted from the early days of commercial air travel. Within developed countries, the rate of individual circulation (in terms of average distances travelled) has increased 1,000-fold in the last 200 years. While the processes of population growth and geographical churn have been at work for the whole of human history, it is in the last two centuries that the momentum of change has gathered increasing pace. As described in Section 2.1, McMichael (2004) recognizes four separate stages. (i) Early human settlements from c.5,000 to c.10,000 years ago enabled enzootic pathogens to enter Homo sapiens populations. Some of these encounters led to the emergence of many of today’s textbook infections: influenza, tuberculosis, cholera, typhoid, smallpox, measles, malaria, and many others. (ii) Eurasian military and commercial contacts c.1,500 to c.3,000 years ago with swapping of dominant infections between the Mediterranean and Chinese civilizations. As described in Section 2.2, the plagues and pestilences of classical Greece and Rome date from this period. (iii) European exploration and imperialism from c.1500 with the transoceanic spread of often lethal infectious diseases. The impact on the Americas, on Australasia, and on remote island populations is well known; ships’ crews and passengers were the devastating vectors. (iv) The fourth great transition is today’s globalization, acting through demographic change and accelerating levels of contacts between the different parts of the world to facilitate disease emergence, re-emergence, and spatial transfer. Global warming, the destabilization of environments, the unparalleled movement of peoples rapidly across the globe through air transport, are all part of an evolving host–microbe relationship (cf. Section 1.3.1).


Author(s):  
David S. Wilcove ◽  
David Rothstein

On April 28, 1987, a biologist hiking through the remote Alakai swamp on the island of Kauai paused to listen to the sweet, flutelike song of a distant bird. He recognized the song as belonging to a Kauai ’o’o (Moho braccatus), a sleek chocolate-brown bird native to these woods. He was surely aware of the significance of this particular song, for during the past four years this particular ’o’o, the very last of its kind, had been the object of much attention among scientists and conservationists. But he could not have known that he was about to become the last person ever to hear it. The next time biologists visited the Alakai swamp, the ’o’o was gone, and yet another American species had moved from the realm of the living to the realm of the dead. The causes of the Kauai ’o’o’s extinction are reasonably clear, although the precise role each factor played in the species’ demise is debatable. Much of the bird’s forested habitat was destroyed for agriculture, leaving only a relatively few safe havens on steep slopes or in wet, inaccessible places. Most of these places, in turn, were eventually overrun with alien species, including feral pigs that destroyed the native vegetation, as well as plants and songbirds transported to Hawaii from around the world. The introduction of mosquitoes to Hawaii, which occurred in 1826 when the crew of a sailing ship dumped the mosquito larvae—infested dregs from their water barrels, created additional problems for Hawaii’s beleaguered birds. The mosquitoes became a vector for the spread of avian malaria and avian pox, diseases that were probably carried by the introduced birds. The native avifauna, presumably including the ’o’o, lacked resistance to these diseases, and many species quickly succumbed. Soon, only the forests at higher elevations, where cold temperatures kept the mosquitoes at bay, offered a disease free environment for the native birds. Eventually, however, the mosque toes reached even these forests, including the Alakai swamp, abetted by feral pig wallows, which created pools of stagnant water ideal for breeding mosquitoes. Thus a combination of factors, including habitat destruction, alien species, and diseases, contributed to the demise of the Kauai ’o’o.


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