Prediction of risk of Coronary Artery Disease based on Framingham Risk Score in association with shift work among nurses

Author(s):  
Farhad Solymanzadeh ◽  
Dariush Rokhafroz ◽  
Marziyeh Asadizaker ◽  
Maryam Dastoorpoor
Herz ◽  
2013 ◽  
Vol 39 (5) ◽  
pp. 638-643 ◽  
Author(s):  
M.R. Sayin ◽  
M.A. Cetiner ◽  
T. Karabag ◽  
I. Akpinar ◽  
E. Sayin ◽  
...  

2011 ◽  
Vol 107 (6) ◽  
pp. 799-804 ◽  
Author(s):  
Naser Ahmadi ◽  
Fereshteh Hajsadeghi ◽  
Roger S. Blumenthal ◽  
Matthew J. Budoff ◽  
Gregg W. Stone ◽  
...  

RMD Open ◽  
2020 ◽  
Vol 6 (3) ◽  
pp. e001364 ◽  
Author(s):  
Isaac T Cheng ◽  
Ka Tak Wong ◽  
Edmund K Li ◽  
Priscilla C H Wong ◽  
Billy T Lai ◽  
...  

ObjectivesThis study aimed to assess the performance of carotid ultrasound (US) parameters alone or in combination with Framingham Risk Score (FRS) in discriminating patients with psoriatic arthritis (PsA) with and without coronary artery disease (CAD).MethodsNinety-one patients with PsA (56 males; age: 50±11 years, disease duration: 9.4±9.2 years) without overt cardiovascular (CV) diseases were recruited. Carotid intima-media thickness (cIMT), the presence of plaque and total plaque area (TPA) was determined by high-resolution US. CAD was defined as the presence of any coronary plaque on coronary CT angiography (CCTA). Obstructive-CAD (O-CAD) was defined as >50% stenosis of the lumen.ResultsThirty-five (38%) patients had carotid plaque. Fifty-four (59%) patients had CAD (CAD+) and 9 (10%) patients had O-CAD (O-CAD+). No significant associations between the presence of carotid plaque and CAD were found. However, cIMT and TPA were higher in both the CAD+ and O-CAD+ group compared with the CAD− or O-CAD− groups, respectively. Multivariate logistic regression analysis revealed that mean cIMT was an independent explanatory variable associated with CAD and O-CAD, while maximum cIMT and TPA were independent explanatory variables associated with O-CAD after adjusting for covariates. The optimal cut-offs for detecting the presence of CAD were FRS >5% and mean cIMT at 0.62 mm (AUC: 0.71; sensitivity: 67%; specificity: 76%), while the optimal cut-offs for detecting the presence of O-CAD were FRS >10% in combination with mean cIMT at 0.73 mm (AUC: 0.71; sensitivity: 56%; specificity: 85%).ConclusionUS parameters including cIMT and TPA may be considered in addition to FRS for CV risk stratification in patients with PsA.


Author(s):  
George R Marzouka ◽  
Leonardo Tamariz ◽  
Ana Palacio ◽  
Hermes Florez ◽  
David Seo ◽  
...  

Background: The Framingham risk score (FRS) predicts the 10-year risk of having a myocardial infarction (MI). However, the accuracy of the FRS in hispanics has not been throughly evaluated. We compared coronary artery disease (CAD) severity with FRS by ethnic groups in patients undergoing cardiac catheterization. Methods: We performed a cross-sectional analysis of 178 consecutive patients who were referred for elective coronary angiography at Jackson Memorial Hospital in Miami. We measured the components of the FRS and evaluated ethnicity by self-report. We evaluated CAD severity based on the coronary angiography results. We defined severe CAD if the patients had >= 70% luminal obstruction in a vessel or >=50% in the left main coronary artery. We also evalauted severity as a continuos score of the number of vessels with narrowings>=50%. We calculated the median and interquartile range (IQR) of FRS and correlated with the CAD severity and the p-value for trend as well as analysis of variance to determine if FRS differed by ethnicity adjusted for confounders. Results: We identified 110 patients who identified as Hispanic and 68 patients identified as non-hispanics. At baseline, Hispanics had a mean FRS of 10.0±3.8 and non-Hispanics had a mean FRS of 10.3±5.9 (p=0.70). In Hispanics the median FRS for patients with >= 70% stenosis was 10% (IQR 8.5-13) compared to <70% stenosis 9 % (IQR 5-13). In non-Hispanics with >= 70% stenosis the median FRS was 12.5% (IQR 10-16) compared to those with <70% stenosis 8 % (IQR 4-11). The same differences were seen when using >=50% stenosis (table). Conclusions: The FRS does not correlate with coronary artery disease severity in Hispanics but does correlate with CAD severity in non-Hispanics. Median and IQR of FRS by degree of stenosis and ethnicity Severity of stenosis * Hispanics Non-Hispanics >=70% 10 (8.5-13) 12.5 (10-16) >=60% 9 (5-13) 8 (4-11) >=50% 10 (9-13) 12 (9-15) <50% 9 (6-13) 8 (5-14) * p<0.01 for comparisons between severe CAD and non-severe CAD by ethnicity


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