scholarly journals Improving solubility and oral bioavailability of a novel antimalarial prodrug: comparing spray-dried dispersions with self-emulsifying drug delivery systems

2020 ◽  
Vol 25 (5) ◽  
pp. 625-639 ◽  
Author(s):  
Suresh Potharaju ◽  
Shravan Kumar Mutyam ◽  
Mingtao Liu ◽  
Carol Green ◽  
Lisa Frueh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Bioavailability ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Spray Dried

Enhancement of oral bioavailability of fenofibrate by solid self-microemulsifying drug delivery systems

2012 ◽  
Vol 39 (9) ◽  
pp. 1431-1438 ◽  
Author(s):  
Gun Gook Kim ◽  
Bijay K. Poudel ◽  
Nirmal Marasini ◽  
Dong Won Lee ◽  
Tran Tuan Hiep ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Bioavailability ◽  
Drug Delivery Systems ◽  
Delivery Systems

Improved oral bioavailability of myricitrin by liquid self-microemulsifying drug delivery systems

2019 ◽  
Vol 52 ◽  
pp. 597-606 ◽  
Author(s):  
Na Man ◽  
Qilong Wang ◽  
Huihua Li ◽  
Michael Adu-Frimpong ◽  
Congyong Sun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Bioavailability ◽  
Drug Delivery Systems ◽  
Delivery Systems

Enhanced oral bioavailability of Wurenchun (Fructus Schisandrae ChinensisExtracts) by self-emulsifying drug delivery systems

2010 ◽  
Vol 36 (11) ◽  
pp. 1356-1363 ◽  
Author(s):  
Bing Shao ◽  
Jingling Tang ◽  
Hongyu Ji ◽  
Hongmei Liu ◽  
Yan Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Bioavailability ◽  
Drug Delivery Systems ◽  
Delivery Systems

scholarly journals Preparation and comparison of spray dried and electrospun bioresorbable drug delivery systems

2015 ◽  
Vol 68 ◽  
pp. 671-679 ◽  
Author(s):  
Péter L. Sóti ◽  
Zsombor K. Nagy ◽  
Geert Serneels ◽  
Balázs Vajna ◽  
Attila Farkas ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Spray Dried

Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems

2009 ◽  
Vol 374 (1-2) ◽  
pp. 66-72 ◽  
Author(s):  
Prabagar Balakrishnan ◽  
Beom-Jin Lee ◽  
Dong Hoon Oh ◽  
Jong Oh Kim ◽  
Young-Im Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Coenzyme Q10 ◽  
Oral Bioavailability ◽  
Drug Delivery Systems ◽  
Delivery Systems

scholarly journals Lipid-based systems as a promising approach for enhancing the bioavailability of poorly water-soluble drugs

2013 ◽  
Vol 63 (4) ◽  
pp. 427-445 ◽  
Author(s):  
Katja Čerpnjak ◽  
Alenka Zvonar ◽  
Mirjana Gašperlin ◽  
Franc Vrečer
Keyword(s):  
Drug Delivery ◽  
Oral Bioavailability ◽  
Drug Delivery Systems ◽  
Water Solubility ◽  
Pharmaceutical Products ◽  
Delivery Systems ◽  
Water Soluble ◽  
Poorly Water Soluble Drugs ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble

Abstract Low oral bioavailability as a consequence of low water solubility of drugs is a growing challenge to the development of new pharmaceutical products. One of the most popular approaches of oral bioavailability and solubility enhancement is the utilization of lipid-based drug delivery systems. Their use in product development is growing due to the versatility of pharmaceutical lipid excipients and drug formulations, and their compatibility with liquid, semi-solid, and solid dosage forms. Lipid formulations, such as self-emulsifying (SEDDS), self-microemulsifying SMEDDS) and self- -nanoemulsifying drug delivery systems (SNEDDS) were explored in many studies as an efficient approach for improving the bioavailability and dissolution rate of poorly water-soluble drugs. One of the greatest advantages of incorporating poorly soluble drugs into such formulations is their spontaneous emulsification and formation of an emulsion, microemulsion or nanoemulsion in aqueous media. This review article focuses on the following topics. First, it presents a classification overview of lipid-based drug delivery systems and mechanisms involved in improving the solubility and bioavailability of poorly water-soluble drugs. Second, the article reviews components of lipid-based drug delivery systems for oral use with their characteristics. Third, it brings a detailed description of SEDDS, SMEDDS and SNEDDS, which are very often misused in literature, with special emphasis on the comparison between microemulsions and nanoemulsions.

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