Self-Nanoemulsifying Drug Delivery Systems (SNEDDS): An Innovative Approach to Improve Oral Bioavailability

Abstract Low oral bioavailability as a consequence of low water solubility of drugs is a growing challenge to the development of new pharmaceutical products. One of the most popular approaches of oral bioavailability and solubility enhancement is the utilization of lipid-based drug delivery systems. Their use in product development is growing due to the versatility of pharmaceutical lipid excipients and drug formulations, and their compatibility with liquid, semi-solid, and solid dosage forms. Lipid formulations, such as self-emulsifying (SEDDS), self-microemulsifying SMEDDS) and self- -nanoemulsifying drug delivery systems (SNEDDS) were explored in many studies as an efficient approach for improving the bioavailability and dissolution rate of poorly water-soluble drugs. One of the greatest advantages of incorporating poorly soluble drugs into such formulations is their spontaneous emulsification and formation of an emulsion, microemulsion or nanoemulsion in aqueous media. This review article focuses on the following topics. First, it presents a classification overview of lipid-based drug delivery systems and mechanisms involved in improving the solubility and bioavailability of poorly water-soluble drugs. Second, the article reviews components of lipid-based drug delivery systems for oral use with their characteristics. Third, it brings a detailed description of SEDDS, SMEDDS and SNEDDS, which are very often misused in literature, with special emphasis on the comparison between microemulsions and nanoemulsions.

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Enhancement of zaleplon oral bioavailability using optimized self-nano emulsifying drug delivery systems and its effect on sleep quality among a sample of psychiatric patients

Drug Delivery ◽

10.1080/10717544.2019.1687613 ◽

2019 ◽

Vol 26 (1) ◽

pp. 1243-1253 ◽

Cited By ~ 3

Author(s):

Maha K. A. Khalifa ◽

Hoda A. Salem ◽

Seham M. Shawky ◽

Heba A. Eassa ◽

Asmaa M. Elaidy

Keyword(s):

Drug Delivery ◽

Sleep Quality ◽

Oral Bioavailability ◽

Drug Delivery Systems ◽

Psychiatric Patients ◽

Delivery Systems

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Improving solubility and oral bioavailability of a novel antimalarial prodrug: comparing spray-dried dispersions with self-emulsifying drug delivery systems

Pharmaceutical Development and Technology ◽

10.1080/10837450.2020.1725893 ◽

2020 ◽

Vol 25 (5) ◽

pp. 625-639 ◽

Cited By ~ 3

Author(s):

Suresh Potharaju ◽

Shravan Kumar Mutyam ◽

Mingtao Liu ◽

Carol Green ◽

Lisa Frueh ◽

...

Keyword(s):

Drug Delivery ◽

Oral Bioavailability ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Spray Dried

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Design and Characterization of Self-Nanoemulsifying Drug Delivery Systems of Rosuvastatin

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2018.11.2.6 ◽

2018 ◽

Vol 11 (2) ◽

pp. 4042-4052

Author(s):

Bhikshapathi D. V. R. N. ◽

Priya Keerthi

Keyword(s):

Drug Delivery ◽

Zeta Potential ◽

Oral Bioavailability ◽

Drug Delivery Systems ◽

Ternary Phase Diagram ◽

Delivery Systems ◽

Water Soluble ◽

Lipid Lowering ◽

Tween 20 ◽

Onset Of Action

Development of self-emulsifying drug delivery systems (SEDDS) are becoming more popular to improve the oral bioavailability of poorly water-soluble drugs. Rosuvastatin is a lipid-lowering agent used in patients suffering from dyslipidemia. It is a competitive inhibitor of 3-hydroxy 3-methyl glutaryl coenzyme A, which converts mevalonate to cholesterol. Rosuvastatin is a BCS class II (poor solubility) drug; hence, SNEDDS are being formulated to enhance oral bioavailability of the drug. In the present study, rosuvastatin SNEDDS were formulated using different oils, surfactant and co-surfactant. The optimized formulation F9 has composition of Las (PEG-8-Caprylic glycerides), Maisine 35-1 and Tween 20 as oil phase, surfactant and co-surfactant respectively. Composition of SNEDDS was optimized using Pseudo-ternary phase diagram, where the formulations showed increased self-emulsification with increased concentration of surfactants. Formulation F9 was found to be best formulation based on evaluation parameters. The particle size of the optimized SNEDDS formulation was found to be 10.9 nm & Z-Average of 55.6 nm indicating all the particles were in the nanometer range. The zeta potential of the optimized SNEDDS formulation was found to be -11.2 mV, which comply with the requirement of the zeta potential for stability. The developed rosuvastatin SNEDDS have the potential to minimize the variability in absorption and provide rapid onset of action of the drug.

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