The Synthesis of Cyclonucleotides with Fixed Glycosidic Bond Linkages as Putative Agonists for P2-Purinergic Receptors

2000 ◽  
Vol 19 (4) ◽  
pp. 805-813 ◽  
Author(s):  
Girolamo Tusa ◽  
Juta K. Reed
Keyword(s):  
Purinergic Receptors ◽  
Glycosidic Bond ◽  
P2 Purinergic Receptors

scholarly journals Purinergic signaling, DAMPs, and inflammation

2020 ◽  
Vol 318 (5) ◽  
pp. C832-C835 ◽  
Author(s):  
Francesco Di Virgilio ◽  
Alba Clara Sarti ◽  
Robson Coutinho-Silva
Keyword(s):  
Plasma Membrane ◽  
Purinergic Receptors ◽  
Purinergic Signaling ◽  
Extracellular Atp ◽  
Main Metabolite ◽  
P2 Purinergic Receptors ◽  
Evolutionary Features ◽  
Multicellular Organisms ◽  
Molecular Patterns ◽  
Damage Associated Molecular Patterns

Danger sensing is one of the most fundamental evolutionary features enabling multicellular organisms to perceive potential threats, escape from risky situations, fight actual intruders, and repair damage. Several endogenous molecules are used to “signal damage,” currently referred to as “alarmins” or “damage-associated molecular patterns” (DAMPs), most being already present within all cells (preformed DAMPs), and thus ready to be released, and others neosynthesized following injury. Over recent years it has become overwhelmingly clear that adenosine 5′-triphosphate (ATP) is a ubiquitous and extremely efficient DAMP (thus promoting inflammation), and its main metabolite, adenosine, is a strong immunosuppressant (thus dampening inflammation). Extracellular ATP ligates and activates the P2 purinergic receptors (P2Rs) and is then degraded by soluble and plasma membrane ecto-nucleotidases to generate adenosine acting at P1 purinergic receptors (P1Rs). Extracellular ATP, P2Rs, ecto-nucleotidases, adenosine, and P1Rs are basic elements of the purinergic signaling network and fundamental pillars of inflammation.

scholarly journals Two types of P2-purinergic receptors in rat hepatocytes

1991 ◽  
Vol 55 ◽  
pp. 134
Author(s):  
Hideaki Tomura ◽  
Fumikazu Okajima ◽  
Yoichi Kondo
Keyword(s):  
Purinergic Receptors ◽  
Rat Hepatocytes ◽  
P2 Purinergic Receptors
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