INHIBITION OF CALCIUM-STIMULATED ATPase IN THE HEN BRAIN P2 SYNAPTOSOMAL FRACTION BY ORGANOPHOSPHORUS ESTERS: RELEVANCE TO DELAYED NEUROPATHY

2001 ◽  
Vol 63 (2) ◽  
pp. 101-113 ◽  
Author(s):  
D. Barber ◽  
J. Hunt ◽  
M. Ehrich
Keyword(s):  
Delayed Neuropathy ◽  
Synaptosomal Fraction ◽  
Organophosphorus Esters

Biochemical and Morphological Validation of a Rodent Model of Organophosphorus-Induced Delayed Neuropathy

1988 ◽  
Vol 4 (3) ◽  
pp. 361-371 ◽  
Author(s):  
Stephanie Padilla ◽  
Bellina Veronesi
Keyword(s):  
Data Base ◽  
Experimental Model ◽  
Nerve Fibers ◽  
Rodent Model ◽  
Experimental Literature ◽  
Delayed Neuropathy

Exposure to certain organophosphates (OPs) produces a delayed degeneration of the longest and largest nerve fibers (OPIDN). Until recently, investigators have used the chicken as the primary experimental model of OPIDN. Although the chicken is extremely sensitive to the ataxia associated with this neuropathy, it lacks an extensive biochemical, electrophysiological and pathological data-base. Because of this we set out to develop a rodent model of OPIDN with morphological and biochemical correlates similar to those seen in the chicken. Historically the rat had been labeled insensitive to OPIDN because of its lack of demonstrable ataxia in response to the neuropathic OPs. This paper describes the validation of a rodent model with biochemical and morphological endpoints similar to those described in the clinical and experimental literature for other models of OPIDN.

Release of ascorbate from a synaptosomal fraction of rat brain

1984 ◽  
Vol 6 (4) ◽  
pp. 491-500 ◽  
Author(s):  
R.A. Grünewald ◽  
M. Fillenz
Keyword(s):  
Rat Brain ◽  
Synaptosomal Fraction

Carbofuran-Induced Delayed Neuropathy

2000 ◽  
Vol 38 (1) ◽  
pp. 43-46 ◽  
Author(s):  
Po-Yi Yang ◽  
Thomas C.Y. Tsao ◽  
Ja-Liang Lin ◽  
Rong-Kuo Lyu ◽  
Ping-Cherng Chiang
Keyword(s):  
Delayed Neuropathy
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