Influence Of Delta-Aminolevulinic Acid Dehydratase Gene Polymorphism on Selected Lead Exposure Biomarkers in a Cohort of Ex-Smelter Workers

2013 ◽  
Vol 76 (15) ◽  
pp. 895-906 ◽  
Author(s):  
Ariane Leroyer ◽  
Bruno Leleu ◽  
Betty Dehon ◽  
Paul Frimat ◽  
Franck Broly ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Lead Exposure ◽  
Aminolevulinic Acid ◽  
Acid Dehydratase ◽  
Exposure Biomarkers

scholarly journals Effects of deltaAminolevulinic Acid Dehydratase Gene Polymorphism on Hematological Parameters and Kidney Function of Lead-exposed Workers

2019 ◽  
Vol 10 (2) ◽  
pp. 89-93 ◽  
Author(s):  
Mona Sobhi Siha ◽  
Dalia Abdel-Hamid Shaker ◽  
Hebatalla Saad Teleb ◽  
Laila Ahmed Rashed
Keyword(s):  
Gene Polymorphism ◽  
Kidney Function ◽  
Lead Exposure ◽  
Aminolevulinic Acid ◽  
Hematological Parameters ◽  
Lead Level ◽  
Lead Toxicity ◽  
Effect Modifier ◽  
Acid Dehydratase ◽  
Exposed Workers

Lead exposure is associated with several health hazards among workers with different individual responses. We conducted this study to determine the possible effects of lead exposure on hematological parameters and kidney function of a group of Egyptian ammunition workers and the interaction of aminolevulinic acid dehydratase (ALAD) G177C gene polymorphisms as an effect modifier. Significant differences were observed between exposed workers with ALAD1-1 and ALAD1-2 genotypes in terms of blood lead level, hematological parameters and kidney function. It seems that δ-ALAD gene polymorphism may be an effect modifier and a marker of genetic susceptibility to lead toxicity.

scholarly journals 183: Δ-Aminolevulinic Acid Dehydratase Variant, Lead Exposure and Cognition in Older Men

2005 ◽  
Vol 161 (Supplement_1) ◽  
pp. S46-S46
Author(s):  
J Weuve ◽  
K T Kelsey ◽  
J Schwartz ◽  
D Bellinger ◽  
P Rajan ◽  
...  
Keyword(s):  
Lead Exposure ◽  
Aminolevulinic Acid ◽  
Older Men ◽  
Acid Dehydratase

scholarly journals Role of δ-Aminolevulinic Acid Dehydratase (ALAD) gene polymorphism in lead induced nephrotoxicity

2014 ◽  
Vol 7 (Suppl 1) ◽  
pp. P50 ◽  
Author(s):  
Mugdha Tiwari ◽  
LJ Bhagia ◽  
I Shaikh ◽  
D Rohila
Keyword(s):  
Gene Polymorphism ◽  
Aminolevulinic Acid ◽  
Acid Dehydratase

Lead concentration in plasma as a biomarker of exposure and risk, and modification of toxicity by δ-aminolevulinic acid dehydratase gene polymorphism

2013 ◽  
Vol 221 (2) ◽  
pp. 102-109 ◽  
Author(s):  
Liting Tian ◽  
Guang Zheng ◽  
Johan Nilsson Sommar ◽  
Yihuai Liang ◽  
Tomas Lundh ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Lead Concentration ◽  
Aminolevulinic Acid ◽  
Biomarker Of Exposure ◽  
Acid Dehydratase
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