scholarly journals Role of δ-Aminolevulinic Acid Dehydratase (ALAD) gene polymorphism in lead induced nephrotoxicity

2014 ◽  
Vol 7 (Suppl 1) ◽  
pp. P50 ◽  
Author(s):  
Mugdha Tiwari ◽  
LJ Bhagia ◽  
I Shaikh ◽  
D Rohila
Keyword(s):  
Gene Polymorphism ◽  
Aminolevulinic Acid ◽  
Acid Dehydratase

scholarly journals Effects of deltaAminolevulinic Acid Dehydratase Gene Polymorphism on Hematological Parameters and Kidney Function of Lead-exposed Workers

2019 ◽  
Vol 10 (2) ◽  
pp. 89-93 ◽  
Author(s):  
Mona Sobhi Siha ◽  
Dalia Abdel-Hamid Shaker ◽  
Hebatalla Saad Teleb ◽  
Laila Ahmed Rashed
Keyword(s):  
Gene Polymorphism ◽  
Kidney Function ◽  
Lead Exposure ◽  
Aminolevulinic Acid ◽  
Hematological Parameters ◽  
Lead Level ◽  
Lead Toxicity ◽  
Effect Modifier ◽  
Acid Dehydratase ◽  
Exposed Workers

Lead exposure is associated with several health hazards among workers with different individual responses. We conducted this study to determine the possible effects of lead exposure on hematological parameters and kidney function of a group of Egyptian ammunition workers and the interaction of aminolevulinic acid dehydratase (ALAD) G177C gene polymorphisms as an effect modifier. Significant differences were observed between exposed workers with ALAD1-1 and ALAD1-2 genotypes in terms of blood lead level, hematological parameters and kidney function. It seems that δ-ALAD gene polymorphism may be an effect modifier and a marker of genetic susceptibility to lead toxicity.

Lead concentration in plasma as a biomarker of exposure and risk, and modification of toxicity by δ-aminolevulinic acid dehydratase gene polymorphism

2013 ◽  
Vol 221 (2) ◽  
pp. 102-109 ◽  
Author(s):  
Liting Tian ◽  
Guang Zheng ◽  
Johan Nilsson Sommar ◽  
Yihuai Liang ◽  
Tomas Lundh ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Lead Concentration ◽  
Aminolevulinic Acid ◽  
Biomarker Of Exposure ◽  
Acid Dehydratase

scholarly journals 681 PB 195 MOLECULAR CHARACTERIZATION OF A cDNA THAT ENCODES 5-AMINOLEVULINIC ACID DEHYDRATASE IN TOMATO

HortScience ◽  
1994 ◽  
Vol 29 (5) ◽  
pp. 530d-530
Author(s):  
Gary F. Polkinz ◽  
David J. Hannapel ◽  
Richard J. Gladon
Keyword(s):  
Fruit Ripening ◽  
Aminolevulinic Acid ◽  
Tomato Fruit ◽  
Northern Analysis ◽  
Chlorophyll Metabolism ◽  
E Coli ◽  
Acid Dehydratase ◽  
Tomato Fruit Ripening

Tomato fruit ripening is characterized by a decrease in chlorophyll content and an increase in lycopene synthesis. We are interested in the role of chlorophyll metabolism as it relates to tomato fruit ripening. 5-Aminolevulinic acid dehydratase (ALAD) is the first committed enzyme in the chlorophyll biosynthetic pathway, and it catalyzes the conversion of two 5-aminolevulinic acid molecules into porphobilinogen. We have isolated a full-length tomato ALAD cDNA clone from a tomato fruit library. Sequence analysis showed that this tomato ALAD was highly homologous to ALAD found in spinach and pea, and the analysis predicted a protein of 46.8 kDa. Southern analysis indicated that 1 to 3 copies of the ALAD gene are present in the tomato genome. Northern analysis suggested that the gene is expressed constitutively throughout tomato fruit development. Currently, we are subcloning the fragment into an E. coli expression vector in order to obtain protein for antibody production for Western analysis.

scholarly journals 5-Aminolevulinic Acid Dehydratase. The Role of Sulphydryl Groups in 5-Aminolevulinic Acid Dehydratase from Bovine Liver

1981 ◽  
Vol 114 (2) ◽  
pp. 263-269 ◽  
Author(s):  
Jasbir S. SEEHRA ◽  
Michael G. GORE ◽  
Abdul G. CHAUDHRY ◽  
Peter M. JORDAN
Keyword(s):  
Aminolevulinic Acid ◽  
Bovine Liver ◽  
Acid Dehydratase ◽  
Sulphydryl Groups
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