Toxicity of some broad-spectrum antibacterials in normal rat liver: the role of mitochondrial membrane permeability transition pore

2019 ◽  
Vol 29 (2) ◽  
pp. 128-137 ◽  
Author(s):  
Olubukola T. Oyebode ◽  
Oluwaseun R. Adebiyi ◽  
Olufunso O. Olorunsogo
Keyword(s):  
Membrane Permeability ◽  
Rat Liver ◽  
Broad Spectrum ◽  
Mitochondrial Membrane ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Mitochondrial Membrane Permeability ◽  
Membrane Permeability Transition ◽  
Normal Rat

scholarly journals In Vitro and In Vivo Activation of Mitochondrial Membrane Permeability Transition Pore Using Triiodothyronine

2016 ◽  
pp. 321-331
Author(s):  
R. ENDLICHER ◽  
Z. DRAHOTA ◽  
Z. ČERVINKOVÁ
Keyword(s):  
Membrane Permeability ◽  
Mitochondrial Membrane ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Mitochondrial Membrane Permeability ◽  
Experimental Conditions ◽  
Membrane Permeability Transition ◽  
Swelling Rate

Using a novel method for evaluating mitochondrial swelling (Drahota et al. 2012a) we studied the effect of calcium (Ca2+), phosphate (Pi), and triiodothyronine (T3) on the opening of mitochondrial membrane permeability transition pore and how they interact in the activation of swelling process. We found that 0.1 mM Pi, 50 µM Ca2+ and 25 µM T3 when added separately increase the swelling rate to about 10 % of maximal values when all three factors are applied simultaneously. Our findings document that under experimental conditions in which Ca2+ and Pi are used as activating factors, the addition of T3 doubled the rate of swelling. T3 has also an activating effect on mitochondrial membrane potential. The T3 activating effect was also found after in vivo application of T3. Our data thus demonstrate that T3 has an important role in opening the mitochondrial membrane permeability pore and activates the function of the two key physiological swelling inducers, calcium and phosphate ions.

scholarly journals Mitochondrial toxicity of organic arsenicals: membrane permeability transition pore opening and respiratory dysfunction

2018 ◽  
Vol 7 (2) ◽  
pp. 191-200 ◽  
Author(s):  
Xiao-Yang Fan ◽  
Lian Yuan ◽  
Can Wu ◽  
Yu-Jiao Liu ◽  
Feng-Lei Jiang ◽  
...  
Keyword(s):  
Membrane Permeability ◽  
Mitochondrial Membrane ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Mitochondrial Membrane Permeability ◽  
Respiratory Dysfunction ◽  
Membrane Permeability Transition ◽  
Isolated Mitochondria ◽  
Permeability Transition Pore Opening ◽  
Pore Opening

Organic arsenicalMOPIMPinduced mitochondrial membrane permeability transition pore opening, respiration suppression and metabolic thermogenesis dysfunction in isolated mitochondria.

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