Toxicity of some broad-spectrum antibacterials in normal rat liver: the role of mitochondrial membrane permeability transition pore

2019 ◽  
Vol 29 (2) ◽  
pp. 128-137 ◽  
Author(s):  
Olubukola T. Oyebode ◽  
Oluwaseun R. Adebiyi ◽  
Olufunso O. Olorunsogo
Keyword(s):  
Membrane Permeability ◽  
Rat Liver ◽  
Broad Spectrum ◽  
Mitochondrial Membrane ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Mitochondrial Membrane Permeability ◽  
Membrane Permeability Transition ◽  
Normal Rat

scholarly journals Role of the mitochondrial membrane permeability transition in cell death

APOPTOSIS ◽  
2006 ◽  
Vol 12 (5) ◽  
pp. 835-840 ◽  
Author(s):  
Yoshihide Tsujimoto ◽  
Shigeomi Shimizu
Keyword(s):  
Cell Death ◽  
Membrane Permeability ◽  
Mitochondrial Membrane ◽  
Permeability Transition ◽  
Mitochondrial Membrane Permeability ◽  
Membrane Permeability Transition

scholarly journals In Vitro and In Vivo Activation of Mitochondrial Membrane Permeability Transition Pore Using Triiodothyronine

2016 ◽  
pp. 321-331
Author(s):  
R. ENDLICHER ◽  
Z. DRAHOTA ◽  
Z. ČERVINKOVÁ
Keyword(s):  
Membrane Permeability ◽  
Mitochondrial Membrane ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Mitochondrial Membrane Permeability ◽  
Experimental Conditions ◽  
Membrane Permeability Transition ◽  
Swelling Rate

Using a novel method for evaluating mitochondrial swelling (Drahota et al. 2012a) we studied the effect of calcium (Ca2+), phosphate (Pi), and triiodothyronine (T3) on the opening of mitochondrial membrane permeability transition pore and how they interact in the activation of swelling process. We found that 0.1 mM Pi, 50 µM Ca2+ and 25 µM T3 when added separately increase the swelling rate to about 10 % of maximal values when all three factors are applied simultaneously. Our findings document that under experimental conditions in which Ca2+ and Pi are used as activating factors, the addition of T3 doubled the rate of swelling. T3 has also an activating effect on mitochondrial membrane potential. The T3 activating effect was also found after in vivo application of T3. Our data thus demonstrate that T3 has an important role in opening the mitochondrial membrane permeability pore and activates the function of the two key physiological swelling inducers, calcium and phosphate ions.

scholarly journals Comparative Study of the Effects of Different Fractions of Ficus Exasperata Vahl on Rat Hepatic Mitochondrial Membrane Permeability Transition Pore

2019 ◽  
Vol 12 (3) ◽  
pp. 15
Author(s):  
Adeola F. Ehigie ◽  
Olajumoke O. Nwaechefu ◽  
Godswill N. Anyasor ◽  
Faith S. Oyelere ◽  
Tosin S. Sangodipe ◽  
...  
Keyword(s):  
Membrane Permeability ◽  
Mitochondrial Membrane ◽  
Inductive Effect ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Hexane Fraction ◽  
Mitochondrial Membrane Permeability ◽  
Methanol Fraction ◽  
Membrane Permeability Transition ◽  
Pore Opening

A number of phytochemicals have been established as potent inducers of the mitochondrial membrane permeability transition (MMPT) pore, a transient structure formed in the inner mitochondrial membrane (IMM). There is however no information on the effect of Ficus exasperata (F. exasperata) a popular medicinal plant, on this pore, necessitating this investigation. The in vitro effects of varying concentrations (200, 400, 600, 800 and 1000µg/ml) of the methanol, n-hexane and ethylacetate fractions of leaf and stem of F. exasperata on MMPT pore opening in experimental rat liver were assessed. Opening of MMPT pore was spectrophotometrically assayed under succinate-energized condition using a modified method of Lapidus and Sokolove, 1993<sup>[34]</sup>. The results obtained for the Stem Methanol Fraction (SMF) and Leaf Methanol Fraction (LMF) show significant (P&lt; 0.05) increases in the extents to which MMPT pore opening was induced at all concentrations compared with the control group, with the highest induction observed at 400µg/ml and the least seen at 1000µg/ml. The inductive effects of Leaf n-hexane Fraction (LHF) and Stem n-hexane Fraction (SHF) increased as concentration increased such that the highest induction observed in LHF and SHF were 2.80 and 2.28 fold increases respectively. Leaf Ethylacetate Fraction (LEF) and Stem Ethylacetate Fraction (SEF) of F. exasperata also show a concentration-dependent effect such that the inductive effect decreased as concentration increased i.e. at 200µg/ml of LEF and SEF, 3.97 and 4.25-fold increases were achieved respectively while the least folds in induction were observed at 1000µg/ml for both at 2.0-fold and 1.97-fold respectively. Taken together, all tested fractions of F. exasperata have significant P &lt; 0.05 inductive effect on the MMPT pore opening at all tested concentrations, the most potent fraction being the SEF. We thus conclude that F. exasperata is an effective inducer of the MMPT pore, albeit, different fractions derived from different parts vary in their potency. Also, F. exasperata could find a great use in the treatment of ailments dependent on the induction of the mitochondrial membrane permeability transition pore opening.

Effect of oral coadministration of artesunate with ferrous sulfate on rat liver mitochondrial membrane permeability transition

2011 ◽  
Vol 34 (3) ◽  
pp. 318-323 ◽  
Author(s):  
Mosebolatan V. Fafowora ◽  
Francis O. Atanu ◽  
Olayinka Sanya ◽  
Olufunso O. Olorunsogo ◽  
Ochuko L. Erukainure
Keyword(s):  
Membrane Permeability ◽  
Rat Liver ◽  
Ferrous Sulfate ◽  
Mitochondrial Membrane ◽  
Permeability Transition ◽  
Mitochondrial Membrane Permeability ◽  
Membrane Permeability Transition
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