Coenzyme Q10 effect on cisplatin-induced oxidative retinal injury in rats

2021 ◽  
pp. 1-7
Author(s):  
Mukadder Sunar ◽  
Gulce Naz Yazici ◽  
Renad Mammadov ◽  
Nezahat Kurt ◽  
Yusuf Kemal Arslan ◽  
...  
Keyword(s):  
Coenzyme Q10 ◽  
Retinal Injury

scholarly journals Comparative Effects of Coenzyme Q10 or n-3 Polyunsaturated Fatty Acid Supplementation on Retinal Angiogenesis in a Rat Model of Oxygen-Induced Retinopathy

Antioxidants ◽  
2018 ◽  
Vol 7 (11) ◽  
pp. 160 ◽  
Author(s):  
Kay Beharry ◽  
Charles Cai ◽  
Faisal Siddiqui ◽  
Sara Chowdhury ◽  
Christina D’Agrosa ◽  
...  
Keyword(s):  
Olive Oil ◽  
Coenzyme Q10 ◽  
Intermittent Hypoxia ◽  
Omega 3 ◽  
Newborn Rats ◽  
Fatty Acid Supplementation ◽  
Oxygen Induced Retinopathy ◽  
Retinal Injury ◽  
Ocular Growth ◽  
Retinal Angiogenesis

Neonatal intermittent hypoxia (IH) or apnea afflicts 70% to 90% of all preterm infants <28 weeks gestation, and is associated with severe retinopathy of prematurity (ROP). We tested the hypotheses that coenzyme Q10 (CoQ10) or omega-3 polyunsaturated fatty acids (n-3 PUFAs) supplementation during neonatal IH reduces the severity of oxygen-induced retinopathy (OIR). Newborn rats were exposed to two IH paradigms: (1) 50% O2 with brief hypoxia (12% O2); or (2) 21% O2 with brief hypoxia, until postnatal day 14 (P14), during which they received daily oral CoQ10 in olive oil, n-3 PUFAs in fish oil, or olive oil only and compared to room air (RA) treated groups. Pups were examined at P14, or placed in RA until P21. Retinal angiogenesis, histopathology, and morphometry were determined. Both IH paradigms produced severe OIR, but these were worsened with 50/12% O2 IH. CoQ10 and n-3 PUFAs reduced the severity of OIR, as well as ocular growth factors in both IH paradigms, but CoQ10 was more effective in 50/12% O2 IH. Supplementation with either CoQ10 or n-3 PUFAs targeting IH-induced retinal injury is individually effective for ameliorating specific characteristics consistent with ROP. Given the complexity of ROP, further studies are needed to determine whether combined CoQ10 and n-3 PUFAs supplementation would optimize their efficacy and result in a better outcome.

scholarly journals Coenzyme Q10 ameliorates oxidative stress and prevents mitochondrial alteration in ischemic retinal injury

APOPTOSIS ◽  
2013 ◽  
Vol 19 (4) ◽  
pp. 603-614 ◽  
Author(s):  
Dongwook Lee ◽  
Keun-Young Kim ◽  
Myoung Sup Shim ◽  
Sang Yeop Kim ◽  
Mark H. Ellisman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Coenzyme Q10 ◽  
Retinal Injury ◽  
Mitochondrial Alteration

Effects of coenzyme Q10 in progressive supranuclear palsy

2008 ◽  
Vol 35 (S 01) ◽  
Author(s):  
M Stamelou ◽  
A Reuss ◽  
U Pilatus ◽  
J Magerkurth ◽  
P Niklowitz ◽  
...  
Keyword(s):  
Progressive Supranuclear Palsy ◽  
Coenzyme Q10

The effect of ezetimibe and simvastatin on coenzyme Q10 levels in healthy men

2005 ◽  
Vol 113 (S 1) ◽  
Author(s):  
I Berthold ◽  
A Naini ◽  
S di Mauro ◽  
W Krone ◽  
HK Berthold
Keyword(s):  
Coenzyme Q10 ◽  
Healthy Men

Recombinant Probiotics Expressing Angiotensin-(1-7) Improves Glucose Metabolism and Diabetes-Induced Renal and Retinal Injury

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 33-LB ◽  
Author(s):  
QIUHONG LI ◽  
KANG XU ◽  
TAO DU ◽  
PING ZHU ◽  
AMRISHA VERMA
Keyword(s):  
Glucose Metabolism ◽  
Retinal Injury
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