Coenzyme Q10 ameliorates oxidative stress and prevents mitochondrial alteration in ischemic retinal injury

Background: Busulfan (Bu) is an anticancer drug with a variety of adverse effects for cancer patients. Oxidative stress has been considered as a common pathological mechanism and it has a key role in the initiation and progression of liver injury by Bu. Aim: The study aimed to evaluate the antioxidant impact of L-Carnitine and Coenzyme Q10 and their protective role against oxidative stress damage in liver tissues. Methods and Material: Thirty-six albino rats were divided equally into six groups. G1 (con), received I.P. injection of DMSO plus 1 ml of distilled water daily by oral gavages; G2 (Bu), received I.P. injection of Bu plus 1 ml of the distilled water daily; G3 (L-Car), received 1 ml of L-Car orally; G4 (Bu + L-Car) received I.P. injection of Bu plus 1 ml of L-Car, G5 (CoQ10) 1 ml of CoQ10 daily; and G6 (Bu + CoQ10) received I.P. injection of Bu plus 1 ml of CoQ10 daily. Results: The recent data showed that Bu induced significant (P<0.05) elevation in serum ALT, AST, liver GSSG, NO, MDA and 8-OHDG, while showing significant (P<0.05) decrease in liver GSH and ATP. On the other hand, L-Carnitine and Coenzyme Q10 ameliorated the negative effects prompted by Bu. Immunohistochemical expression of caspase-3 in liver tissues reported pathological alterations in Bu group while also showed significant recovery in L-Car more than CoQ10. Conclusion: L-Car, as well as CoQ10, can enhance the hepatotoxic effects of Bu by promoting energy production in oxidative phosphorylation process and by scavenging the free radicals.

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Comparison of coenzyme Q10 or fish oil for prevention of intermittent hypoxia-induced oxidative injury in neonatal rat lungs

Respiratory Research ◽

10.1186/s12931-021-01786-w ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Christina D’Agrosa ◽

Charles L. Cai ◽

Faisal Siddiqui ◽

Karen Deslouches ◽

Stephen Wadowski ◽

...

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Lung Injury ◽

Fish Oil ◽

Coenzyme Q10 ◽

Intermittent Hypoxia ◽

Oxidative Injury ◽

Adverse Outcomes ◽

Neonatal Rat ◽

Antioxidant Systems

Abstract Background Neonatal intermittent hypoxia (IH) results in oxidative distress in preterm infants with immature antioxidant systems, contributing to lung injury. Coenzyme Q10 (CoQ10) and fish oil protect against oxidative injury. We tested the hypothesis that CoQ10 is more effective than fish oil for prevention of IH-induced lung injury in neonatal rats. Methods Newborn rats were exposed to two clinically relevant IH paradigms at birth (P0): (1) 50% O2 with brief hypoxia (12% O2); or (2) room air (RA) with brief hypoxia (12% O2), until P14 during which they were supplemented with daily oral CoQ10, fish oil, or olive oil from P0 to P14. Pups were studied at P14 or placed in RA until P21 with no further treatment. Lungs were assessed for histopathology and morphometry; biomarkers of oxidative stress and lipid peroxidation; and antioxidants. Results Of the two neonatal IH paradigms 21%/12% O2 IH resulted in the most severe outcomes, evidenced by histopathology and morphometry. CoQ10 was effective for preserving lung architecture and reduction of IH-induced oxidative stress biomarkers. In contrast, fish oil resulted in significant adverse outcomes including oversimplified alveoli, hemorrhage, reduced secondary crest formation and thickened septae. This was associated with elevated oxidants and antioxidants activities. Conclusions Data suggest that higher FiO2 may be needed between IH episodes to curtail the damaging effects of IH, and to provide the lungs with necessary respite. The negative outcomes with fish oil supplementation suggest oxidative stress-induced lipid peroxidation.

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Hepatoprotective effect of taurine and coenzyme Q10 and their combination against acrylamide-induced oxidative stress in rats

Tropical Journal of Pharmaceutical Research ◽

10.4314/tjpr.v16i8.14 ◽

2017 ◽

Vol 16 (8) ◽

pp. 1849 ◽

Cited By ~ 1

Author(s):

Afaf Abbass Sayed Saleh ◽

Mona Ismail Shahin ◽

Neveen Atef Kelada

Keyword(s):

Oxidative Stress ◽

Coenzyme Q10 ◽

Hepatoprotective Effect

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Protective effect of coenzyme Q10 nanoparticles against monocrotophos induced oxidative stress in kidney tissues of rats

Biologia ◽

10.1007/s11756-021-00732-x ◽

2021 ◽

Author(s):

Vinay Malik ◽

Jagjeet Singh ◽

Amit Kumar ◽

Vijay Kumar

Keyword(s):

Oxidative Stress ◽

Protective Effect ◽

Coenzyme Q10

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Effects of short-term coenzyme Q10 supplementation on markers of oxidative stress and inflammation after downhill running in male mountaineers

Science & Sports ◽

10.1016/j.scispo.2015.02.012 ◽

2015 ◽

Vol 30 (6) ◽

pp. 328-334 ◽

Cited By ~ 2

Author(s):

L. Abdizadeh ◽

A. Jafari ◽

M. Armanfar

Keyword(s):

Oxidative Stress ◽

Coenzyme Q10 ◽

Short Term ◽

Downhill Running ◽

Markers Of Oxidative Stress ◽

Coenzyme Q10 Supplementation

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Coenzyme Q10 in combination with triple therapy regimens ameliorates oxidative stress and lipid peroxidation in chronic gastritis associated withH. pyloriinfection

The Journal of Clinical Pharmacology ◽

10.1002/jcph.508 ◽

2015 ◽

Vol 55 (8) ◽

pp. 842-847 ◽

Cited By ~ 5

Author(s):

Asghar Rahmani ◽

Ghobad Abangah ◽

Atefeh Moradkhani ◽

Mohammad Reza Hafezi Ahmadi ◽

Khairollah Asadollahi

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Triple Therapy ◽

Chronic Gastritis ◽

Coenzyme Q10

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Comparative Effects of Coenzyme Q10 or n-3 Polyunsaturated Fatty Acid Supplementation on Retinal Angiogenesis in a Rat Model of Oxygen-Induced Retinopathy

Antioxidants ◽

10.3390/antiox7110160 ◽

2018 ◽

Vol 7 (11) ◽

pp. 160 ◽

Cited By ~ 6

Author(s):

Kay Beharry ◽

Charles Cai ◽

Faisal Siddiqui ◽

Sara Chowdhury ◽

Christina D’Agrosa ◽

...

Keyword(s):

Olive Oil ◽

Coenzyme Q10 ◽

Intermittent Hypoxia ◽

Omega 3 ◽

Newborn Rats ◽

Fatty Acid Supplementation ◽

Oxygen Induced Retinopathy ◽

Retinal Injury ◽

Ocular Growth ◽

Retinal Angiogenesis

Neonatal intermittent hypoxia (IH) or apnea afflicts 70% to 90% of all preterm infants <28 weeks gestation, and is associated with severe retinopathy of prematurity (ROP). We tested the hypotheses that coenzyme Q10 (CoQ10) or omega-3 polyunsaturated fatty acids (n-3 PUFAs) supplementation during neonatal IH reduces the severity of oxygen-induced retinopathy (OIR). Newborn rats were exposed to two IH paradigms: (1) 50% O2 with brief hypoxia (12% O2); or (2) 21% O2 with brief hypoxia, until postnatal day 14 (P14), during which they received daily oral CoQ10 in olive oil, n-3 PUFAs in fish oil, or olive oil only and compared to room air (RA) treated groups. Pups were examined at P14, or placed in RA until P21. Retinal angiogenesis, histopathology, and morphometry were determined. Both IH paradigms produced severe OIR, but these were worsened with 50/12% O2 IH. CoQ10 and n-3 PUFAs reduced the severity of OIR, as well as ocular growth factors in both IH paradigms, but CoQ10 was more effective in 50/12% O2 IH. Supplementation with either CoQ10 or n-3 PUFAs targeting IH-induced retinal injury is individually effective for ameliorating specific characteristics consistent with ROP. Given the complexity of ROP, further studies are needed to determine whether combined CoQ10 and n-3 PUFAs supplementation would optimize their efficacy and result in a better outcome.

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