Bilateral ankle oedema in a patient taking escitalopram

2009 ◽  
Vol 10 (4-3) ◽  
pp. 939-941 ◽  
Author(s):  
Vasilios G. Masdrakis ◽  
Panagiotis Oulis ◽  
Anastasios V. Kouzoupis ◽  
George V. Masdrakis ◽  
Constantin R. Soldatos
Keyword(s):  
1979 ◽  
Vol 56 (4) ◽  
pp. 305-316 ◽  
Author(s):  
E. S. Williams ◽  
M. P. Ward ◽  
J. S. Milledge ◽  
W. R. Withey ◽  
M. W. J. Older ◽  
...  

1. The effect of 7 consecutive days of strenuous exercise, hill-walking, on water balance and distribution was studied in five subjects. The exercise was preceded and followed by 3 control days. The diet was fixed throughout but water was allowed ad libitum. 2. Packed cell volume was measured daily. Serum electrolytes and arginine vasopressin were measured twice daily. Daily water, sodium and potassium balances were calculated. 3. During exercise there was a fall in packed cell volume, reaching a maximum of 11% by day 5 and a retention of sodium reaching a cumulative maximum of 358 mmol by day 6. During and immediately after exercise there was a retention of potassium, reaching a total of 120 mmol by day 3 after stopping exercise. 4. There was a loss of 650 ml of water on day 1 of exercise, followed by a modest retention reaching a cumulative maximum of 650 ml on day 5 of exercise. 5. Neither arginine vasopressin nor serum electrolyte concentrations were affected by exercise. 6. From the packed cell volume, sodium and water balances it was calculated that by day 5 of exercise there was an increase in plasma volume of 0·68 litre (22%), an increase in interstitial fluid volume of 2·0 litres (17%) and a decrease in intracellular fluid volume of 1·8 litres (8%). 7. These changes, together with the clinical observation of facial and ankle oedema during the experiment, suggest that continuous exercise may cause oedema and thus may be a factor in the aetiology of high-altitude oedema.


2004 ◽  
Vol 19 (2) ◽  
pp. 57-64 ◽  
Author(s):  
J T Hobbs ◽  
M A W Vandendriessche

The veins of the popliteal fossa are more complex than is generally realised. It is frequently taught that the short saphenous vein need only be divided deep to the popliteal fascia. However, the pattern and level of termination of the short saphenous vein shows wide variation. Sometimes, the short saphenous vein is normal and the pathology involves other veins. The 'vein of the popliteal fossa' may sometimes be present as a large tortuous varicosity and pierce the fascia to become superficial at the back of the knee. Incompetence of a gastrocnemius vein, usually the medial, may cause swelling and discomfort within the calf yet nothing is apparent. Awareness may be precipitated by attempting to wear tight fitting boots or trousers when the difference in calf circumference is recognised yet there is no ankle oedema. Next a venous flare or dilated venules appear over a perforator site, usually the mid-calf perforator, but sometimes the Boyd's perforator, filling the posterior arch tributary of the greater saphenous vein. Incompetence of a gastrocnemius vein is suggested by the history and clinical examination. Reflux is demonstrated by Doppler ultrasound and accurately localized by duplex ultrasound with colour-flow imaging. The anatomy is clearly visualized by venography.Large gastrocnemius veins are seen in athletes and ballerinas with well-developed calf muscles and such veins are physiological and should not be interrupted. It is imperative that reflux is demonstrated before surgical treatment is offered. Treatment involves ligating the incompetent gastrocnemius vein through a small incision over the popliteal fossa. If the mid-calf perforator is also incompetent it is divided deep to the fascia through a small vertical incision and the fascial defect closed. The distal short saphenous vein may be removed by partial stripping and any tributaries removed by phlebectomies using Oesch hooks. Strong below-knee stockings are worn for a month following this surgery.


1991 ◽  
Vol 30 (3) ◽  
pp. 303-307 ◽  
Author(s):  
Abdul-Majeed Salmasi ◽  
Gianni Belcaro ◽  
Andrew N. Nicolaides
Keyword(s):  

2003 ◽  
Vol 17 (3) ◽  
pp. 207-212 ◽  
Author(s):  
R Fogari ◽  
G D Malamani ◽  
A Zoppi ◽  
A Mugellini ◽  
A Rinaldi ◽  
...  

Author(s):  
Johannes W.G. Jacobs ◽  
Marlies C. van der Goes ◽  
Johannes W.J. Bijlsma ◽  
José A.P. da Silva

Glucocorticoids still are the most effective, broadly applicable, and cheapest immunosuppressive drugs used in the treatment of rheumatic conditions. In rheumatoid arthritis (RA) they are applied for their symptomatic effects but also for disease-modifying properties. The risk of adverse effects of glucocorticoid therapy in RA is dependent on patient (age, comorbidity, and comedication), glucocorticoid dose, type and route of administration, and treatment duration. Toxicity is important in treatment decisions, but for low-dose glucocorticoids, overestimation of the risk of adverse effects should be avoided. Monitoring safety of this therapy only requires that good follow-up of rheumatic patients in daily practice is extended with screening for osteoporosis, and pretreatment assessments of fasting blood glucose levels, risk factors for glaucoma, and a check for ankle oedema.


1993 ◽  
Vol 2 (3) ◽  
pp. 205-211 ◽  
Author(s):  
Jeremy J. Hammond ◽  
Stephen A. Cutler
Keyword(s):  

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