scholarly journals Doxorubicin pretreatment enhances FAPα/survivin co-targeting DNA vaccine anti-tumor activity primarily through decreasing peripheral MDSCs in the 4T1 murine breast cancer model

2020 ◽  
Vol 9 (1) ◽  
pp. 1747350 ◽  
Author(s):  
Fei Geng ◽  
Xin Bao ◽  
Ling Dong ◽  
Qian-Qian Guo ◽  
Jie Guo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Vaccine ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
Anti Tumor Activity

Structure-based discovery of a small non-peptidic Neuropilins antagonist exerting in vitro and in vivo anti-tumor activity on breast cancer model

2014 ◽  
Vol 349 (2) ◽  
pp. 120-127 ◽  
Author(s):  
Lucia Borriello ◽  
Matthieu Montès ◽  
Yves Lepelletier ◽  
Bertrand Leforban ◽  
Wang-Qing Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
Anti Tumor Activity

scholarly journals Demonstration of anti-tumor activity of oncolytic measles virus strains in a malignant pleural effusion breast cancer model

2009 ◽  
Vol 122 (3) ◽  
pp. 745-754 ◽  
Author(s):  
Ianko D. Iankov ◽  
Pavlos Msaouel ◽  
Cory Allen ◽  
Mark J. Federspiel ◽  
Peggy A. Bulur ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Pleural Effusion ◽  
Measles Virus ◽  
Malignant Pleural Effusion ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
Anti Tumor Activity ◽  
Virus Strains

scholarly journals Co-administration of GP96 and Her2/neu DNA vaccine in a Her2 breast cancer model

2010 ◽  
Vol 15 (6) ◽  
pp. 977-984 ◽  
Author(s):  
Nafiseh Pakravan ◽  
Ladan Langroudi ◽  
Monire Hajimoradi ◽  
Zuhair Mohammad Hassan
Keyword(s):  
Breast Cancer ◽  
Dna Vaccine ◽  
Cancer Model ◽  
Her2 Breast Cancer ◽  
Breast Cancer Model

scholarly journals Osteopontin binds ICOSL promoting tumor metastasis

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Davide Raineri ◽  
Chiara Dianzani ◽  
Giuseppe Cappellano ◽  
Federica Maione ◽  
Gianluca Baldanzi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Metastasis ◽  
Immune Checkpoints ◽  
Cancer Model ◽  
Therapeutic Approaches ◽  
Breast Cancer Model ◽  
4T1 Breast Cancer ◽  
Anti Tumor Activity

Abstract ICOSL/ICOS are costimulatory molecules pertaining to immune checkpoints; their binding transduces signals having anti-tumor activity. Osteopontin (OPN) is here identified as a ligand for ICOSL. OPN binds a different domain from that used by ICOS, and the binding induces a conformational change in OPN, exposing domains that are relevant for its functions. Here we show that in vitro, ICOSL triggering by OPN induces cell migration, while inhibiting anchorage-independent cell growth. The mouse 4T1 breast cancer model confirms these data. In vivo, OPN-triggering of ICOSL increases angiogenesis and tumor metastatization. The findings shed new light on ICOSL function and indicate that another partner beside ICOS may be involved; they also provide a rationale for developing alternative therapeutic approaches targeting this molecular trio.

scholarly journals Targeted Therapeutic Remodeling of the Tumor Microenvironment Improves an HER-2 DNA Vaccine and Prevents Recurrence in a Murine Breast Cancer Model

2011 ◽  
Vol 71 (17) ◽  
pp. 5688-5696 ◽  
Author(s):  
Debbie Liao ◽  
Ze Liu ◽  
Wolfgang J. Wrasidlo ◽  
Yunping Luo ◽  
Giang Nguyen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Dna Vaccine ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
Her 2 ◽  
Targeted Therapeutic

scholarly journals Interleukin-7 Enhances the in Vivo Anti-tumor Activity of Tumor-reactive CD8+T cells with Induction of IFN-gamma in a Murine Breast Cancer Model

2014 ◽  
Vol 15 (1) ◽  
pp. 265-271 ◽  
Author(s):  
Chun-Hui Yuan ◽  
Xue-Qin Yang ◽  
Cheng-Liang Zhu ◽  
Shao-Ping Liu ◽  
Bi-Cheng Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cells ◽  
Cd8 T Cells ◽  
Cancer Model ◽  
Ifn Gamma ◽  
Interleukin 7 ◽  
Breast Cancer Model ◽  
Anti Tumor Activity
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