Potential Application of Silicified Microcrystalline Cellulose in Direct-Fill Formulations for Automatic Capsule-Filling Machines

Biodegradable and bio-based substitutes for conventional plastics are on the rise in these past decades. One of the applications of bioplastic is for biomedical implants or bioimplant. Starch was plasticized using glycerol at varying amounts (40% and 60% of dry starch mass) to produce thermoplastic starch (TPS). A reinforcement filler of microcrystalline cellulose (MCC) was used to improve the mechanical properties. The MCC content in this study was also varied (0%, 2%, 4%, and 8% w/w). This paper studies the mechanical properties of starch-MCC composites for their potential as bioimplant. The optimum glycerol and MCC contents from the results are 40% glycerol and 8% MCC with 2.97 MPa tensile strength and 7.20% strain at break. Thus, the sample has the potential application in bioimplant material for trabecular bone replacement, which has an average tensile strength of 2 MPa and strains at a break of 2.5%.

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Use of crospovidone as pelletization aid as alternative to microcrystalline cellulose: effects on pellet properties

Drug Development and Industrial Pharmacy ◽

10.1080/03639040902902401 ◽

2009 ◽

pp. 090526005142032-8

Author(s):

P. Verheyen ◽

K.-J. Steffens ◽

P. Kleinebudde

Keyword(s):

Microcrystalline Cellulose ◽

Pelletization Aid

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Post-mortem Peyer’s patches: Their potential application in forensic medicine

Immunopharmacology and Immunotoxicology ◽

10.1080/08923970902902437 ◽

2009 ◽

Vol 00 (00) ◽

pp. 090513010017019-7

Author(s):

Biagio Solarino ◽

Giancarlo Di Vella ◽

Thea Magrone ◽

Felicita Jirillo ◽

Angela Tafaro ◽

...

Keyword(s):

Forensic Medicine ◽

Potential Application ◽

Peyer's Patches ◽

Peyer’S Patches ◽

Post Mortem

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Immunomodulation using genetically engineered bacteria for type III-mediated delivery of heterologous antigens and cytokines: Potential application in vaccine and therapeutical developments

Immunopharmacology and Immunotoxicology ◽

10.1080/08923970902817890 ◽

2009 ◽

Vol 00 (00) ◽

pp. 090924084723050-4

Author(s):

Mustapha Chamekh

Keyword(s):

Potential Application ◽

Genetically Engineered ◽

Type Iii ◽

Genetically Engineered Bacteria ◽

Heterologous Antigens ◽

Engineered Bacteria

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Comparison of Caseinolytic and Fibrinolytic Assays for Plasmin (Fibrinolysin) in “Fibrinolytic Agents”

Thrombosis and Haemostasis ◽

10.1055/s-0038-1649426 ◽

1966 ◽

Vol 15 (01/02) ◽

pp. 252-272

Author(s):

K. M Moser ◽

Mary Belle Frey

Keyword(s):

Linear Relationship ◽

Potential Application ◽

Fibrinolytic Agents ◽

Linear Portion

Summary1. Caseinolytic and fibrinolytic systems for assay of plasmin in fibrinolytic agents are described which are based upon the determinations of AE/min during the linear portion of the casein-plasmin and fibrin-plasmin reaction curves respectively. A " caseinolytic-rate " unit and “fibrinolytic-rate " unit of ÄE/min × 103 during the linear portion of the respective curves are proposed.2. Data are presented indicating that a reliably linear relationship exists between plasmin concentration and these caseinolytic - and fibrinolytic-rate units.3. Data comparing results obtained with the proposed assay techniques and previously-used casein and fibrinolytic techniques are presented.4. Formulae by which caseinolytic-rate and fibrinolytic-rate units can be roughly converted into Remmert-Cohen type plasmin units are offered.5. The theoretical and practical problems which have influenced development of assays for fibrinolytic components are discussed.6. The advantages of the plasmin “rate unit” techniques vis a vis existing assays are delineated.7. The potential application of the techniques to measurements other than the plasmin content of fibrinolytic agents is discussed.

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Effects of release modifier on Carvedilol release from Kollidon SR based matrix

International Current Pharmaceutical Journal ◽

10.3329/icpj.v1i8.11095 ◽

2012 ◽

Vol 1 (8) ◽

pp. 186 ◽

Cited By ~ 1

Author(s):

Urmi Das ◽

Mohammad Salim Hossain

Keyword(s):

Drug Release ◽

Sustained Release ◽

Microcrystalline Cellulose ◽

Matrix Tablets ◽

Dissolution Time ◽

Release Mechanism ◽

Matrix Tablet ◽

Weight Variation ◽

The Matrix ◽

Tablet Formulations

Sustained release Carvedilol matrix tablets constituting Kollidon SR were developed in this study in an attempt to investigate the effect of release modifiers on the release profile of Carvedilol from matrix. Three matrix tablet formulations were prepared by direct compression of Kollidon SR in combination with release modifier (HPMC and Microcrystalline Cellulose) and magnesium stearate. Tablets containing only Kollidon SR with the active ingredient demonstrated a rapid rate of drug release. Incorporation of HPMC in the matrix tablet prolonged the release of drug but incorporation of Microcrystalline Cellulose showed superimposable release pattern with an initial burst effect as confirmed by mean dissolution time and Higuchi release rate data. After 7 hours of dissolution, Carvedilol release from the matrix systems were 91.42%, 83.41%, from formulation F1 and F2 respectively. Formulation F3 exhibited 100 % release at 4 hours. All the tablet formulations showed acceptable pharmaco-technical properties and complied with the in-house specifications for tablet weight variation, friability, hardness, thickness, and diameter. Prepared tablets also showed sustained release property for carvedilol. The drug release mechanism from the matrix tablets of F1 and F2 was found to be followed by Fickian and F3 by Non-Fickian mechanism.DOI: <a href="http://dx.doi.org/10.3329/icpj.v1i8.11095">http://dx.doi.org/10.3329/icpj.v1i8.11095</a> International Current Pharmaceutical Journal 2012, 1(8): 186-192

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