Subcellular platelet factor VIII antigen and von Willebrand factor.
1975 ◽
Vol 141
(5)
◽
pp. 1101-1113
◽
Keyword(s):
Subcellular membrane and granule fractions derived from human platelets contain factor VIIII antigen and von Willebrand factor activity but not factor VII procoagulant activity. Circulating platelets constitute a significant reservoir of plasma factor VIII antigen, containing approximately 15% of the amount of factor VIII antigen present in platelet-poor plasma. The antibiotic ristocetin, which aggregates human platelets in the presence of von Willebrand factor, nonspecifically precipitates platelet membrane factor VIII antigen. Thus normal platelets contain surface-bound as well as internally stored von Willebrand factor, a protein synthesized by endothelial cells which is necessary for normal platelet function in vivo.
Keyword(s):
Keyword(s):
1976 ◽
Vol 35
(01)
◽
pp. 120-123
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Keyword(s):
1984 ◽
Vol 52
(01)
◽
pp. 057-059
◽
Keyword(s):
1998 ◽
Vol 76
(12)
◽
pp. 809-812
◽
Keyword(s):
Keyword(s):
1979 ◽