scholarly journals Studies on the role of the host immune response in recovery from Friend virus leukemia. II. Cell-mediated immunity.

1976 ◽  
Vol 143 (1) ◽  
pp. 85-99 ◽  
Author(s):  
B Chesebro ◽  
K Wehrly
Keyword(s):  
Leukemia Virus ◽  
Mouse Strains ◽  
Cell Mediated Immunity ◽  
Effector Cells ◽  
Friend Leukemia ◽  
Virus Leukemia ◽  
Congenic Mouse Strains ◽  
Friend Leukemia Virus

Congenic mouse strains differing only at genes within the H-2 complex were found to have virus-specific cytotoxic effector cells in their spleens during or after recovery from Friend leukemia virus-induced splenomegaly. These effector cells were theta-positive T lymphocytes which functioned in vitro without help or inhibition by B lymphocytes or glass-adherent cells. The antigenic specificities recognized by the effector cells were viral-induced cellular antigens apparently different from those identified by serological techniques.

scholarly journals Erythroid colony induction without erythropoietin by Friend leukemia virus in vitro.

1975 ◽  
Vol 72 (9) ◽  
pp. 3556-3560 ◽  
Author(s):  
B. J. Clarke ◽  
A. A. Axelrad ◽  
M. M. Shreeve ◽  
D. L. McLeod
Keyword(s):  
Leukemia Virus ◽  
Friend Leukemia ◽  
Friend Leukemia Virus

Release of spleen focus-forming virus (SFFV) from differentiation inducible promyelocytic leukemia cell lines transformed in vitro by friend leukemia virus

Virology ◽  
1980 ◽  
Vol 105 (2) ◽  
pp. 425-435 ◽  
Author(s):  
Joel S. Greenberger ◽  
Robert J. Eckner ◽  
Wolfram Ostertag ◽  
Giulia Colletta ◽  
Sandra Boschetti ◽  
...  
Keyword(s):  
Cell Lines ◽  
Leukemia Virus ◽  
Leukemia Cell ◽  
Promyelocytic Leukemia ◽  
Leukemia Cell Lines ◽  
Friend Leukemia ◽  
Friend Leukemia Virus

scholarly journals GENETIC CONTROL OF CELL-MEDIATED LYMPHOLYSIS IN MOUSE

1974 ◽  
Vol 140 (6) ◽  
pp. 1534-1546 ◽  
Author(s):  
Dolores J. Schendel ◽  
Fritz H. Bach
Keyword(s):  
Genetic Control ◽  
Congenic Mouse ◽  
Mouse Strains ◽  
Effector Cells ◽  
Congenic Mouse Strains ◽  
Cytotoxic Effector

H-2 congenic mouse strains were tested in vitro to investigate the genetic control of cell-mediated lympholysis (CML). Combinations were selected such that differences in various segments of H-2 could be examined for their ability to stimulate production of effector cells and to serve as targets for lysis. Particular emphasis was directed towards understanding the roles of LD and SD. SD-region differences are important in the sensitization of effector cells and they also function as strong targets for lysis, or as markers for the CML targets. LD differences are also important for sensitization of cytotoxic effector cells, but they serve only as very weak targets for lysis. Collaboration occurs between LD and SD in generation of CML. The nature of this interaction can be of two types: together LD and SD can produce CML which neither difference alone can stimulate; LD can enhance a CML response stimulated by SD-region differences alone.

scholarly journals Long-term culture of bone marrow-derived preleukemic cells from F-MuLV- infected mice

Blood ◽  
1986 ◽  
Vol 68 (1) ◽  
pp. 193-199
Author(s):  
JM Heard ◽  
B Sola ◽  
MA Martial ◽  
S Fichelson ◽  
S Gisselbrecht
Keyword(s):  
Bone Marrow ◽  
Cell Lines ◽  
Bone Marrow Cells ◽  
Leukemia Virus ◽  
Friend Leukemia ◽  
Normal Sensitivity ◽  
Friend Leukemia Virus

The replication-competent Friend leukemia virus (F-MuLV) induces leukemias involving three hematopoietic lineages after a latent period of several months. In an attempt to elucidate the early events of the leukemogenic process, we looked for a method allowing the isolation and the long term in vitro maintenance of preleukemic cells. When established as long-term cultures according to the technique described by Dexter et al, bone marrow cells obtained from 7/7 apparently healthy F-MuLV-infected preleukemic mice led to the accumulation of immature myeloblastic cells, and to the generation of permanent myeloblastic cell lines, which in most cases further became tumorigenic in preirradiated recipient animals. The delays required to obtain cell lines were shorter when the duration of the in vivo infection was longer, suggesting that these cells were committed into the leukemogenic pathway before their transfer into culture flasks. The myelomonocytic preleukemic cells exhibited normal sensitivity to purified preparations of CSFs, but acquired the capacity to grow in the absence of exogenous CSF stimulation. Examination of integrated provirus copies demonstrated that the preleukemic cell proliferation involved a single or a few clones which may progress in vitro from a preleukemic to a fully malignant stage without major modifications of the integrated provirus copies.

Role of lymphoid cells in age-related change of susceptibility to Friend leukemia virus-induced leukemia

2001 ◽  
Vol 122 (2) ◽  
pp. 219-232 ◽  
Author(s):  
Shuichi Yamaguchi ◽  
Masanobu Kitagawa ◽  
Miori Inoue ◽  
Yuri Tejima ◽  
Mayumi Kimura ◽  
...  
Keyword(s):  
Leukemia Virus ◽  
Lymphoid Cells ◽  
Age Related ◽  
Friend Leukemia ◽  
Friend Leukemia Virus
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