Simian sarcoma virus-encoded gag-related protein: In vitro cleavage by friend leukemia virus-associated proteolytic activity

Virology ◽  
1985 ◽  
Vol 143 (1) ◽  
pp. 143-152 ◽  
Author(s):  
Rudolf Hafenrichter ◽  
Heinz-Jürgen Thiel
Keyword(s):  
Proteolytic Activity ◽  
Leukemia Virus ◽  
Related Protein ◽  
Friend Leukemia ◽  
Sarcoma Virus ◽  
Simian Sarcoma Virus ◽  
Friend Leukemia Virus

scholarly journals Erythroid colony induction without erythropoietin by Friend leukemia virus in vitro.

1975 ◽  
Vol 72 (9) ◽  
pp. 3556-3560 ◽  
Author(s):  
B. J. Clarke ◽  
A. A. Axelrad ◽  
M. M. Shreeve ◽  
D. L. McLeod
Keyword(s):  
Leukemia Virus ◽  
Friend Leukemia ◽  
Friend Leukemia Virus

Release of spleen focus-forming virus (SFFV) from differentiation inducible promyelocytic leukemia cell lines transformed in vitro by friend leukemia virus

Virology ◽  
1980 ◽  
Vol 105 (2) ◽  
pp. 425-435 ◽  
Author(s):  
Joel S. Greenberger ◽  
Robert J. Eckner ◽  
Wolfram Ostertag ◽  
Giulia Colletta ◽  
Sandra Boschetti ◽  
...  
Keyword(s):  
Cell Lines ◽  
Leukemia Virus ◽  
Leukemia Cell ◽  
Promyelocytic Leukemia ◽  
Leukemia Cell Lines ◽  
Friend Leukemia ◽  
Friend Leukemia Virus

scholarly journals Long-term culture of bone marrow-derived preleukemic cells from F-MuLV- infected mice

Blood ◽  
1986 ◽  
Vol 68 (1) ◽  
pp. 193-199
Author(s):  
JM Heard ◽  
B Sola ◽  
MA Martial ◽  
S Fichelson ◽  
S Gisselbrecht
Keyword(s):  
Bone Marrow ◽  
Cell Lines ◽  
Bone Marrow Cells ◽  
Leukemia Virus ◽  
Friend Leukemia ◽  
Normal Sensitivity ◽  
Friend Leukemia Virus

The replication-competent Friend leukemia virus (F-MuLV) induces leukemias involving three hematopoietic lineages after a latent period of several months. In an attempt to elucidate the early events of the leukemogenic process, we looked for a method allowing the isolation and the long term in vitro maintenance of preleukemic cells. When established as long-term cultures according to the technique described by Dexter et al, bone marrow cells obtained from 7/7 apparently healthy F-MuLV-infected preleukemic mice led to the accumulation of immature myeloblastic cells, and to the generation of permanent myeloblastic cell lines, which in most cases further became tumorigenic in preirradiated recipient animals. The delays required to obtain cell lines were shorter when the duration of the in vivo infection was longer, suggesting that these cells were committed into the leukemogenic pathway before their transfer into culture flasks. The myelomonocytic preleukemic cells exhibited normal sensitivity to purified preparations of CSFs, but acquired the capacity to grow in the absence of exogenous CSF stimulation. Examination of integrated provirus copies demonstrated that the preleukemic cell proliferation involved a single or a few clones which may progress in vitro from a preleukemic to a fully malignant stage without major modifications of the integrated provirus copies.

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