Synthetic Fc peptide-mediated regulation of the immune response. I. Characterization of the immunomodulating properties of a synthetic 23-amino acid peptide derived from the sequence of the CH3 domain of human IgG1.
1983 ◽
Vol 157
(3)
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pp. 947-956
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Keyword(s):
A synthetic 23-amino acid peptide derived from the CH3 domain of human IgG1 was found to be a potent adjuvant as well as a polyclonal activator. The Fc peptide was found to enhance human and murine humoral, and T cell-mediated immune responses. Moreover, in vivo administration of Fc peptide enhanced murine natural killer cell activity. The synthetic Fc peptide was found to be more potent, on a molar basis, than native Fc fragments in inducing polyclonal antibody production and potentiating immune responses.
Keyword(s):
1991 ◽
Vol 59
(8)
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pp. 2818-2821
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1993 ◽
Vol 13
(7)
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pp. 753-764
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2015 ◽
Vol 13
(3)
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pp. 249-256
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Keyword(s):
Keyword(s):
1994 ◽
Vol 18
(6)
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pp. 1361-1367
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