scholarly journals Cytolytic responses: cadherins put out the fire

2006 ◽  
Vol 203 (2) ◽  
pp. 261-264 ◽  
Author(s):  
Marco Colonna
Keyword(s):  
T Cells ◽  
Mhc Class I ◽  
Cd8 T Cells ◽  
Class I ◽  
Cytotoxic Lymphocytes ◽  
Intracellular Pathogens ◽  
Cell Recognition ◽  
Cytotoxic Cells ◽  
Mhc Class I Molecules ◽  
Response Activation

Cytotoxic lymphocytes, such as natural killer (NK) cells and CD8+ T cells, provide an essential defense against intracellular pathogens and tumors. During target cell recognition, these cells receive both activating and inhibitory signals. The cell must evaluate these opposing signals and determine the appropriate response: activation or inhibition. Classically, inhibitory signals are mediated by receptors that recognize MHC class I molecules (1). But recent studies, including one in this issue, suggest that MHC class I-independent inhibitory signals can also result in inhibition of cytotoxic cells.

scholarly journals Constitutive versus Activation-dependent Cross-Presentation of Immune Complexes by CD8+ and CD8− Dendritic Cells In Vivo

2002 ◽  
Vol 196 (6) ◽  
pp. 817-827 ◽  
Author(s):  
Joke M.M. den Haan ◽  
Michael J. Bevan
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Mhc Class I ◽  
Cd8 T Cells ◽  
Immune Complexes ◽  
Class I ◽  
Cross Presentation ◽  
Deficient Mice ◽  
Mhc Class I Molecules

Murine splenic dendritic cells (DCs) can be divided into two subsets based on CD8α expression, but the specific role of each subset in stimulation of T cells is largely unknown. An important function of DCs is the ability to take up exogenous antigens and cross-present them in the context of major histocompatibility complex (MHC) class I molecules to CD8+ T cells. We previously demonstrated that, when cell-associated ovalbumin (OVA) is injected into mice, only the CD8+ DC subset cross-presents OVA in the context of MHC class I. In contrast to this selectivity with cell-associated antigen, we show here that both DC subsets isolated from mice injected with OVA/anti-OVA immune complexes (OVA-IC) cross-present OVA to CD8+ T cells. The use of immunoglobulin G Fc receptor (FcγR) common γ-chain–deficient mice revealed that the cross-presentation by CD8− DCs depended on the expression of γ-chain–containing activating FcγRs, whereas cross-presentation by CD8+ DCs was not reduced in γ-chain–deficient mice. These results suggest that although CD8+ DCs constitutively cross-present exogenous antigens in the context of MHC class I molecules, CD8− DCs only do so after activation, such as via ligation of FcγRs. Cross-presentation of immune complexes may play an important role in autoimmune diseases and the therapeutic effect of antitumor antibodies.

scholarly journals Expansion and Function of CD8+T Cells Expressing Ly49 Inhibitory Receptors Specific for MHC Class I Molecules

2004 ◽  
Vol 173 (6) ◽  
pp. 3773-3782 ◽  
Author(s):  
Nicolas Anfossi ◽  
Scott H. Robbins ◽  
Sophie Ugolini ◽  
Philippe Georgel ◽  
Kasper Hoebe ◽  
...  
Keyword(s):  
T Cells ◽  
Mhc Class I ◽  
Cd8 T Cells ◽  
Class I ◽  
Inhibitory Receptors ◽  
And Function ◽  
Mhc Class I Molecules

scholarly journals Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells

PLoS ONE ◽  
2017 ◽  
Vol 12 (11) ◽  
pp. e0187314 ◽  
Author(s):  
Shalini Sethumadhavan ◽  
Murillo Silva ◽  
Phaethon Philbrook ◽  
Thao Nguyen ◽  
Stephen M. Hatfield ◽  
...  
Keyword(s):  
T Cells ◽  
Tumor Cell ◽  
Mhc Class I ◽  
Hypoxia Inducible Factor ◽  
Class I ◽  
Cell Recognition ◽  
Antigen Presenting ◽  
Mhc Class I Molecules

scholarly journals A sufficient role of MHC class I molecules on hepatocytes in anti-plasmodial activity of CD8+ T cells in vivo

2015 ◽  
Vol 6 ◽  
Author(s):  
Jing Huang ◽  
Tiffany Tsao ◽  
Min Zhang ◽  
Urvashi Rai ◽  
Moriya Tsuji ◽  
...  
Keyword(s):  
T Cells ◽  
Mhc Class I ◽  
Cd8 T Cells ◽  
Class I ◽  
Mhc Class I Molecules

scholarly journals Expression of EPHRIN-A1, SCINDERIN and MHC class I molecules in head and neck cancers and relationship with the prognostic value of intratumoral CD8+T cells

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Meriem Hasmim ◽  
Cécile Badoual ◽  
Philippe Vielh ◽  
Françoise Drusch ◽  
Virginie Marty ◽  
...  
Keyword(s):  
T Cells ◽  
Head And Neck ◽  
Mhc Class I ◽  
Cd8 T Cells ◽  
Prognostic Value ◽  
Head And Neck Cancers ◽  
Class I ◽  
Mhc Class I Molecules

scholarly journals Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets

2017 ◽  
Vol 1 (20) ◽  
pp. 1773-1785 ◽  
Author(s):  
Anne Zufferey ◽  
Edwin R. Speck ◽  
Kellie R. Machlus ◽  
Rukhsana Aslam ◽  
Li Guo ◽  
...  
Keyword(s):  
T Cells ◽  
Mhc Class I ◽  
Cd8 T Cells ◽  
Class I ◽  
Foreign Antigen ◽  
Key Points ◽  
Mhc Class I Molecules

Key Points Megakaryocytes process and present endogenous/exogenous antigens on MHC class I molecules to activate CD8+ T cells. Megakaryocytes can transfer MHC class I molecules loaded with foreign antigen to proplatelets in vitro.

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