scholarly journals Single Nucleotide Polymorphisms in Genes for 2′‐5′‐Oligoadenylate Synthetase and RNase L in Patients Hospitalized with West Nile Virus Infection

2005 ◽  
Vol 192 (10) ◽  
pp. 1741-1748 ◽  
Author(s):  
Imtiaz Yakub ◽  
Kristy M. Lillibridge ◽  
Ana Moran ◽  
Omar Y. Gonzalez ◽  
John Belmont ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Virus Infection ◽  
Single Nucleotide Polymorphisms ◽  
West Nile Virus Infection ◽  
Rnase L ◽  
Nucleotide Polymorphisms ◽  
Oligoadenylate Synthetase ◽  
West Nile ◽  
Single Nucleotide

Genetic variants associated with susceptibility of Ashkenazi Jews to West Nile virus infection

2014 ◽  
Vol 143 (4) ◽  
pp. 857-863 ◽  
Author(s):  
N. DANIAL-FARRAN ◽  
S. EGHBARIA ◽  
N. SCHWARTZ ◽  
Z. KRA-OZ ◽  
N. BISHARAT
Keyword(s):  
West Nile Virus ◽  
Genetic Variants ◽  
Disease Burden ◽  
West Nile Virus Infection ◽  
Ashkenazi Jewish ◽  
Nucleotide Polymorphisms ◽  
Ashkenazi Jews ◽  
West Nile ◽  
Single Nucleotide ◽  
Negative Controls

SUMMARYThe epidemiology of West Nile virus (WNV) in Israel is different from other neighbouring countries in the Middle East where disease burden has been minimal. We analysed a cohort of Ashkenazi Jewish patients with symptomatic WNV infection (n = 39), and WNV-negative controls (n = 61), for nine genetic variants that has been suggested to be associated with susceptibility to WNV. Two single nucleotide polymorphisms were significantly more frequent in WNV-infected than non-infected individuals, rs7280422 (MX1) [odds ratio (OR) 4·05, 95% confidence interval (CI) 2·04–8·03, P < 0·001] and rs3213545 (OASL) (OR 1·85, 95% CI 1·03–3·3, P = 0·03). Genetic polymorphism may play a significant role in susceptibility to WNV infection in Ashkenazi Jews

scholarly journals Genetic Variants and Susceptibility to Neurological Complications Following West Nile Virus Infection

2011 ◽  
Vol 204 (7) ◽  
pp. 1031-1037 ◽  
Author(s):  
Mark Loeb ◽  
Sasha Eskandarian ◽  
Mark Rupp ◽  
Neil Fishman ◽  
Leanne Gasink ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Virus Infection ◽  
Genetic Variants ◽  
Statistical Significance ◽  
West Nile Virus Infection ◽  
Neurological Complications ◽  
Type I ◽  
Nucleotide Polymorphisms ◽  
West Nile ◽  
Α Subunit

Abstract To determine genetic factors predisposing to neurological complications following West Nile virus infection, we analyzed a cohort of 560 neuroinvasive case patients and 950 control patients for 13 371 mostly nonsynonymous single-nucleotide polymorphisms (SNPs). The top 3 SNPs on the basis of statistical significance were also in genes of biological plausibility: rs2066786 in RFC1 (replication factor C1) (P = 1.88 × 10−5; odds ratio [OR], 0.68 [95% confidence interval {CI}, .56–.81]); rs2298771 in SCN1A (sodium channel, neuronal type I α subunit) (P = 5.87 × 10−5; OR, 1.47 [95% CI, 1.21–1.77]); and rs25651 in ANPEP (ananyl aminopeptidase) (P = 1.44 × 10−4; OR, 0.69 [95% CI, .56–.83]). Additional genotyping of these SNPs in a separate sample of 264 case patients and 296 control patients resulted in a lack of significance in the replication cohort; joint significance was as follows: rs2066786, P = .0022; rs2298771, P = .005; rs25651, P = .042. Using mostly nonsynonymous variants, we therefore did not identify genetic variants associated with neuroinvasive disease.

Sign in / Sign up

Export Citation Format

Share Document