scholarly journals Early Archiving and Predominance of Nonnucleoside Reverse Transcriptase Inhibitor–Resistant HIV‐1 among Recently Infected Infants Born in the United States

2007 ◽  
Vol 195 (10) ◽  
pp. 1402-1410 ◽  
Author(s):  
Deborah Persaud ◽  
Paul Palumbo ◽  
Carrie Ziemniak ◽  
Jie Chen ◽  
Stuart C. Ray ◽  
...  
Keyword(s):  
United States ◽  
Reverse Transcriptase ◽  
The United States ◽  
Transcriptase Inhibitor ◽  
Nonnucleoside Reverse Transcriptase Inhibitor ◽  
Reverse Transcriptase Inhibitor ◽  
Hiv 1

Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor

Science ◽  
1990 ◽  
Vol 250 (4986) ◽  
pp. 1411-1413 ◽  
Author(s):  
V. Merluzzi ◽  
K. Hargrave ◽  
M Labadia ◽  
K Grozinger ◽  
M Skoog ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Transcriptase Inhibitor ◽  
Nonnucleoside Reverse Transcriptase Inhibitor ◽  
Reverse Transcriptase Inhibitor ◽  
Hiv 1

scholarly journals In Vitro Cross-Resistance Profiles of Rilpivirine, Dapivirine, and MIV-150, Nonnucleoside Reverse Transcriptase Inhibitor Microbicides in Clinical Development for the Prevention of HIV-1 Infection

2017 ◽  
Vol 61 (7) ◽  
Author(s):  
Nicholas S. Giacobbi ◽  
Nicolas Sluis-Cremer
Keyword(s):  
Reverse Transcriptase ◽  
Genital Tract ◽  
Transcriptase Inhibitor ◽  
Cross Resistance ◽  
Nonnucleoside Reverse Transcriptase Inhibitor ◽  
Immunodeficiency Virus ◽  
Reverse Transcriptase Inhibitor ◽  
Hiv 1

ABSTRACT Rilpivirine (RPV), dapivirine (DPV), and MIV-150 are in development as microbicides. It is not known whether they will block infection of circulating nonnucleoside reverse transcriptase inhibitor (NNRTI)-resistant human immunodeficiency virus type 1 (HIV-1) variants. Here, we demonstrate that the activity of DPV and MIV-150 is compromised by many resistant viruses containing single or double substitutions. High DPV genital tract concentrations from DPV ring use may block replication of resistant viruses. However, MIV-150 genital tract concentrations may be insufficient to inhibit many resistant viruses, including those harboring K103N or Y181C.

scholarly journals Capravirine, a Nonnucleoside Reverse‐Transcriptase Inhibitor in Patients Infected with HIV‐1: A Phase 1 Study

2004 ◽  
Vol 190 (11) ◽  
pp. 1957-1961 ◽  
Author(s):  
Benjamin E. Gewurz ◽  
Mark Jacobs ◽  
Jo Ann Proper ◽  
Thomas A. Dahl ◽  
Tamio Fujiwara ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Phase 1 ◽  
Transcriptase Inhibitor ◽  
Phase 1 Study ◽  
Nonnucleoside Reverse Transcriptase Inhibitor ◽  
Reverse Transcriptase Inhibitor ◽  
Hiv 1
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