Construction and evaluation of hyaluronic acid-based copolymers as a targeted chemotherapy drug carrier for cancer therapy

2020 ◽  
Vol 31 (30) ◽  
pp. 305702
Author(s):  
Yuting Tang ◽  
Minglong Chen ◽  
Qian Xie ◽  
Lu Li ◽  
Lei Zhu ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Drug Carrier ◽  
Targeted Chemotherapy ◽  
Chemotherapy Drug

Self-assembled hyaluronic acid nanoparticles as a potential drug carrier for cancer therapy: synthesis, characterization, and in vivo biodistribution

2009 ◽  
Vol 19 (24) ◽  
pp. 4102 ◽  
Author(s):  
Ki Young Choi ◽  
Kyung Hyun Min ◽  
Jin Hee Na ◽  
Kuiwon Choi ◽  
Kwangmeyung Kim ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Drug Carrier ◽  
Potential Drug ◽  
In Vivo Biodistribution ◽  
Self Assembled

Microwave Absorbing Fe3O4@mTiO2 Nanoparticles as an Intelligent Drug Carrier for Microwave-Triggered Synergistic Cancer Therapy

2017 ◽  
Vol 17 (8) ◽  
pp. 5139-5146 ◽  
Author(s):  
Hongxia Peng ◽  
Jilin Hu ◽  
Chuanyue Hu ◽  
Tengyan Wu ◽  
Xiuying Tian
Keyword(s):  
Cancer Therapy ◽  
Drug Carrier ◽  
Microwave Absorbing

scholarly journals Folate-Functionalized Mesoporous Hollow SnO2 Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy

2018 ◽  
Vol 2018 ◽  
pp. 1-11
Author(s):  
Huiling Lv ◽  
Chao Wu ◽  
Xuan Liu ◽  
Andi Bai ◽  
Yue Cao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Liver Cancer ◽  
Drug Carrier ◽  
In Vitro Release ◽  
Hollow Structure ◽  
Amorphous State ◽  
Outer Diameter ◽  
Drug Delivery Carrier

In this study, we prepared PTX-loaded mesoporous hollow SnO2 nanofibers conjugated with folic acid (SFNFP) for liver cancer therapy. According to SEM and TEM characterization, SFNF showed a mesoporous hollow structure. The average outer diameter was 200 nm, and the wall thickness was 50 nm. The DSC and XRD study showed that PTX in the channels of nanofibers was present in an amorphous state. The in vitro release experiments demonstrated that SFNF could efficiently improve the dissolution rate of PTX. Both in vitro cell experiments and in vivo antitumor experiments showed that SFNFP could efficiently inhibit the growth of liver cancer cells. Therefore, SFNF is a promising targeting antitumor drug delivery carrier.

scholarly journals Preclinical Evaluation and Monitoring of the Therapeutic Response of a Dual Targeted Hyaluronic Acid Nanodrug

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Minglong Chen ◽  
Wenqi Zhang ◽  
Kai Yuan ◽  
Mingxiang Bo ◽  
Bin Chen ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Therapeutic Response ◽  
Drug Carrier ◽  
Treated Group ◽  
Great Promise ◽  
Positron Emission ◽  
Evaluation And Monitoring ◽  
Chemotherapy Agents ◽  
Xenograft Tumor Growth

Chemotherapy is a powerful cancer treatment but suffers from poor biocompatibility and a lack of tumor targeting. Here, we developed a CD44-targeted polymeric nanocomplex by encapsulating 10-hydroxycamptothecin (HCPT) into hyaluronic acid nanoparticles (HANP) for targeted cancer therapy. In vitro, the HANP/HCPT showed improved cytotoxicity to five cancer cell lines including HT29, A549, MDA-MB-231, HepG2, and MDA-MB-435 versus free HCPT. After systemic administration into MDA-MB-231 breast cancer xenograft, tumor growth was significantly inhibited 5.25 ± 0.21 times in the HANP/HCPT treated group relative to the nontreated group. In addition, the treatment response was also accessed and confirmed by 18F-fluoro-2-deoxy-D-glucose ([18F] FDG) positron emission tomography (PET). The MDA-MB-231 tumors responded to HANP/HCPT 7 days after the first treatment, which benefits treatment strategy adjustment and personalization. No apparent systemic toxic effects were seen in mice treated with HANP/HCPT. In summary, the HANPs have great promise as a targeted drug carrier for cancer chemotherapy. Our HANP platform can also deliver other hydrophobic chemotherapy agents.

Bioreducible core-crosslinked hyaluronic acid micelle for targeted cancer therapy

2015 ◽  
Vol 200 ◽  
pp. 158-166 ◽  
Author(s):  
Hwa Seung Han ◽  
Ki Young Choi ◽  
Hyewon Ko ◽  
Jueun Jeon ◽  
G. Saravanakumar ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Targeted Cancer Therapy

Hollow hyaluronic acid particles by competition between adhesive and cohesive properties of catechol for anticancer drug carrier

2017 ◽  
Vol 164 ◽  
pp. 309-316 ◽  
Author(s):  
Jeongwook Lee ◽  
Ki Chun Yoo ◽  
Jaehyoung Ko ◽  
Bowon Yoo ◽  
Joohuei Shin ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Anticancer Drug ◽  
Drug Carrier ◽  
Cohesive Properties
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