Self-assembled hyaluronic acid nanoparticles as a potential drug carrier for cancer therapy: synthesis, characterization, and in vivo biodistribution

2009 ◽  
Vol 19 (24) ◽  
pp. 4102 ◽  
Author(s):  
Ki Young Choi ◽  
Kyung Hyun Min ◽  
Jin Hee Na ◽  
Kuiwon Choi ◽  
Kwangmeyung Kim ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Drug Carrier ◽  
Potential Drug ◽  
In Vivo Biodistribution ◽  
Self Assembled

Hyaluronic acid and polyethylenimine self-assembled polyion complexes as pH-sensitive drug carrier for cancer therapy

2015 ◽  
Vol 134 ◽  
pp. 81-87 ◽  
Author(s):  
Jing-Xiao Chen ◽  
Min Wang ◽  
Hui-Hui Tian ◽  
Jing-Hua Chen
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Drug Carrier ◽  
Ph Sensitive ◽  
Self Assembled ◽  
Polyion Complexes

Construction and evaluation of hyaluronic acid-based copolymers as a targeted chemotherapy drug carrier for cancer therapy

2020 ◽  
Vol 31 (30) ◽  
pp. 305702
Author(s):  
Yuting Tang ◽  
Minglong Chen ◽  
Qian Xie ◽  
Lu Li ◽  
Lei Zhu ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Drug Carrier ◽  
Targeted Chemotherapy ◽  
Chemotherapy Drug

scholarly journals Folate-Functionalized Mesoporous Hollow SnO2 Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy

2018 ◽  
Vol 2018 ◽  
pp. 1-11
Author(s):  
Huiling Lv ◽  
Chao Wu ◽  
Xuan Liu ◽  
Andi Bai ◽  
Yue Cao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Liver Cancer ◽  
Drug Carrier ◽  
In Vitro Release ◽  
Hollow Structure ◽  
Amorphous State ◽  
Outer Diameter ◽  
Drug Delivery Carrier

In this study, we prepared PTX-loaded mesoporous hollow SnO2 nanofibers conjugated with folic acid (SFNFP) for liver cancer therapy. According to SEM and TEM characterization, SFNF showed a mesoporous hollow structure. The average outer diameter was 200 nm, and the wall thickness was 50 nm. The DSC and XRD study showed that PTX in the channels of nanofibers was present in an amorphous state. The in vitro release experiments demonstrated that SFNF could efficiently improve the dissolution rate of PTX. Both in vitro cell experiments and in vivo antitumor experiments showed that SFNFP could efficiently inhibit the growth of liver cancer cells. Therefore, SFNF is a promising targeting antitumor drug delivery carrier.

scholarly journals In vivo biodistribution of siRNA and cisplatin administered using CD44-targeted hyaluronic acid nanoparticles

2013 ◽  
Vol 172 (3) ◽  
pp. 699-706 ◽  
Author(s):  
Shanthi Ganesh ◽  
Arun K. Iyer ◽  
Florence Gattacceca ◽  
David V. Morrissey ◽  
Mansoor M. Amiji
Keyword(s):  
Hyaluronic Acid ◽  
In Vivo Biodistribution

Paclitaxel loaded hyaluronic acid nanoparticles for targeted cancer therapy: In vitro and in vivo analysis

2015 ◽  
Vol 72 ◽  
pp. 510-518 ◽  
Author(s):  
Reju G. Thomas ◽  
MyeongJu Moon ◽  
SeJy Lee ◽  
Yong Yeon Jeong
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Targeted Cancer Therapy ◽  
In Vivo Analysis

scholarly journals Fluorescent Labeling of Hyaluronic Acid-Chitosan Nanocarriers by Protein-Stabilized Gold Nanoclusters

Crystals ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1113
Author(s):  
Árpád Turcsányi ◽  
Ditta Ungor ◽  
Edit Csapó
Keyword(s):  
Hyaluronic Acid ◽  
Drug Carrier ◽  
Fluorescent Microscopy ◽  
Gold Nanoclusters ◽  
Fluorescent Labeling ◽  
Colloid Stability ◽  
Wide Range ◽  
Mass Ratios ◽  
Important Field

In medical research the visualization of drug carrier accumulation and release of the loaded drugs in vivo is an important field. In this work, two protein-stabilized gold nanoclusters (Au NCs) as effective fluorescent reporters (FRs) were investigated for labeling of biocompatible chitosan-modified hyaluronic acid based nanocarriers having two different structures. The colloid stability of the labeled carriers was studied by dynamic light scattering and Zeta potential measurements, while the changes in the fluorescence of the lysozyme- (LYZ) and bovine serum albumin (BSA)-stabilized Au NCs were analyzed by spectrofluorimetry and confocal fluorescent microscopy. We found that the labeling was effective with a wide range of marker:carrier mass ratios, and the fluorescence of the NCs and the colloid stability of the complexes were retained. Labeling during preparation and subsequent labeling were compared, and based on composition (nanocluster:carrier mass ratio) and structure of the complex systems we preferred the latter method, as it left the Au NCs free for further modifications. Considering both marker:carrier mass ratios and emission intensities, the LYZ-stabilized Au NCs proved to be better labels. The core-shell type carrier formulations showed increased fluorescence with LYZ-stabilized NCs, presumably from aggregation induced emission.

Near-infrared ratiometric self-assembled theranostic nanoprobe: imaging and tracking cancer chemotherapy

2020 ◽  
Vol 56 (25) ◽  
pp. 3629-3632 ◽  
Author(s):  
Xinwei Tian ◽  
Zhao Li ◽  
Ning Ding ◽  
Jiahang Zhang
Keyword(s):  
Cancer Therapy ◽  
Real Time ◽  
Cancer Chemotherapy ◽  
Near Infrared ◽  
Self Assembled

A novel near-infrared ratiometric fluorescent theranostic nanoprobe is applied for real-time fluorescence tracking and imaging cancer therapy in vivo and in situ.

scholarly journals A versatile method for the selective core-crosslinking of hyaluronic acid nanogels via ketone-hydrazide chemistry: from chemical characterization to in vivo biodistribution

2018 ◽  
Vol 6 (7) ◽  
pp. 1754-1763 ◽  
Author(s):  
Francielle Pelegrin Garcia ◽  
Marlène Rippe ◽  
Mychelle V. P. Companhoni ◽  
Talitha Fernandes Stefanello ◽  
Benoit Louage ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Blood Circulation ◽  
Chemical Characterization ◽  
Circulation Time ◽  
In Vivo Biodistribution ◽  
Tumor Accumulation

Nanogels show long in vivo blood circulation time and high tumor accumulation.

Self-assembled nanoparticles based on glycol chitosan bearing hydrophobic moieties as carriers for doxorubicin: In vivo biodistribution and anti-tumor activity

Biomaterials ◽  
2006 ◽  
Vol 27 (1) ◽  
pp. 119-126 ◽  
Author(s):  
Jae Hyung Park ◽  
Seunglee Kwon ◽  
Minsu Lee ◽  
Hesson Chung ◽  
Ji-Hyun Kim ◽  
...  
Keyword(s):  
Glycol Chitosan ◽  
In Vivo Biodistribution ◽  
Self Assembled ◽  
Anti Tumor Activity
Sign in / Sign up

Export Citation Format

Share Document