Based on the eccentric compression performance testing of the out-of-planes of 4 pieces of different pre-stressed composite masonry walls with holes and constructional columns, the pre-stress’s influences on the horizontal and vertical transmission and distribution, emergence and development of cracks, deformation of the components and fracture morphology and mechanism of the section stress along composite wall with holes are revealed. The testing shows that the pre-stress not only improves comprehensively the load-carrying properties of composite wall, but its fracture mechanism and mechanical model are the same as that of the non-pre-stressed composite wall, so that the same design approach can be used. And it provides further experimental basis to supplement and improve the basic theory and computation methods of eccentric compression of composite wall’s out-of-plane in the current masonry structure specifications. Only crack resistance and bearing capacity are studied in this article.