scholarly journals Determination of Methylisothiazolinone and Methylchloroisothiazolinone in personal care products by HPLC-DAD

2021 ◽  
Vol 947 (1) ◽  
pp. 012022
Author(s):  
Vy Pham Ngoc Thuy ◽  
Tran Viet Hung ◽  
Phan Nguyen Truong Thang ◽  
Trung Dang-Bao ◽  
Tran Thi Kieu Anh
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Personal Care Products ◽  
Ho Chi Minh City ◽  
Personal Care ◽  
Allergic Contact ◽  
Growth Of Bacteria ◽  
Shower Gel

Abstract Preservatives are often utilized to prevent growth of bacteria and extend shell-life of personal care products (PCPs). This causes an increase in the number of cases of allergic contact dermatitis to preservatives. This study focused on the determination of two isothiazolinones (MI and MCI) in PCPs by HPLC-DAD. Different pretreatment methods were examined for different sample matrices. Recoveries were over 80% with %RSD < 6% in three studied sample matrices (wet tissue, shampoo and cream) at three different spiked levels. The method was applied to determine MI and MCI in 84 PCPs (shampoo, shower gel, cream, etc.) purchased in Ho Chi Minh City, Vietnam from March to July in 2021. MI and MCI were detected in some PCPs.

scholarly journals INVESTIGATION OF THE CHEMICAL COMPOSITION AND EFFICIENCY OF SEED OIL OF SPINDLE TREE (EUONYMUS EUROPAEA L.) ON THE MODEL OF NON-ALLERGIC DERMATITIS

2018 ◽  
Vol 3 ◽  
pp. 45-54
Author(s):  
Olha Vrubel ◽  
Igor Nektegaev ◽  
Volodymyr Antonyuk
Keyword(s):  
Fatty Acids ◽  
Gas Chromatography ◽  
Chemical Composition ◽  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Silica Gel ◽  
Seed Oil ◽  
Anti Inflammatory ◽  
Allergic Contact

The aim of the research was to study the chemical composition and effectiveness of the seed oil of Spindle tree (Euonymus europaea L.) on the non-allergic contact dermatitis model. The oil was obtained by the extraction by petroleum ether from the seeds. The analysis of fatty acids and determination of their quantitative content was carried out using gas chromatography. Determination of carotenoids and tocopherols content in fatty oils was carried out after chromatography on a silica gel column. Investigation of anti-inflammatory action of the Spindle tree seed oil on white rats was carried. Determination of biochemical parameters of blood plasma was performed on the semi-automatic biochemical analyzer BS3000M (Poland). The yield of oil was 20–28 % of the weight of the seeds. Nine fatty acids were identified in the oil by the gas chromatography, among which 4 are unsaturated (oleic, palmitoleic, linoleic and linolenic), which together make up 87.79 % of all fatty acids from this oil. Spindle tree oil contains 26±5 mg – % carotenoids and 40±5 mg – % tocopherols, which were separated by chromatography on a silica gel column. There were no symptoms of intoxication with the introduction of Spindle tree oil in the stomach of rats and it can be classified in the 4 the grade of danger in accordance with GOST 12.1.005-88. The anti-inflammatory activity of Spindle tree oil in comparison with the oil of Sea buckthorn on the model of non-allergic contact dermatitis was weaker, but sufficient to recommend it for the treatment of skin diseases in ointments.

scholarly journals The European Baseline Series in Romania: Results of Patch Testing in Contact Dermatitis and Determination of the Most Frequently Awareness in Adult Patients

2019 ◽  
Vol 70 (4) ◽  
pp. 1337-2341 ◽  
Author(s):  
Maria-Magdalena Constantin ◽  
Stefana Bucur ◽  
Clara Matei ◽  
Iuliana Elena Nita ◽  
Traian Constantin
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Patch Testing ◽  
Potassium Dichromate ◽  
Contact Allergy ◽  
Demographic Data ◽  
Positive Patch Test ◽  
Post Test ◽  
Allergic Contact

In Romania, data on patch testing are lacking and the significance and applicability of the European baseline series (EBS) needs to be evaluated. The aim of the study was to examine the prevalence of contact allergy to the EBS and to determine the most common post-test sensitization occurred in the population of patients with suspected allergic contact dermatitis in Romania. Demographic data were collected from 252 patients with suspected allergic contact dermatitis. Pacients were patch tested with 28-allergen EBS.The positive patch test was observed in 80.16% patients. The most prevalent contact allergens were nickel sulphate (15.08%), fragrance mix I & II (13.10%) and potassium dichromate (9.52%). Differences in sensitization prevalences to some allergens of the EBS compared with other European countries were recognized. The current EBS is a suitable diagnostic tool for contact allergy in Romania.

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