A Green Analytical Method Using Polyurethane Foam for The Extraction and Determination of Lauryl Ether Sulfate in Personal Care Hygiene Products

A green methodology was developed for the extraction and determination of lauryl ether sulfate in raw materials and commercial liquid soap and shower gel samples. The method avoids the use of organic solvents, offering a simple, cheap, and safe analysis. The methodology is based on the sorption of an ionic pair consisting of a cationic dye and an anionic surfactant onto polyurethane foam. The experimental variables were optimized by chemometry to obtain the conditions that maximized extraction of the ionic pair. Digital imaging and spectrophotometry were used for quantification in the linear concentration range from 10.0 to 100 mg L-1. The limits of detection and quantification were, respectively, 2.71 and 9.28 mg L-1 for digital imaging, and 1.74 and 5.83 mg L-1 for spectrophotometry. The methods showed good results when applied to commercial samples, with recoveries in the range 96.8-103%.

Determination of Methylisothiazolinone and Methylchloroisothiazolinone in personal care products by HPLC-DAD

Preservatives are often utilized to prevent growth of bacteria and extend shell-life of personal care products (PCPs). This causes an increase in the number of cases of allergic contact dermatitis to preservatives. This study focused on the determination of two isothiazolinones (MI and MCI) in PCPs by HPLC-DAD. Different pretreatment methods were examined for different sample matrices. Recoveries were over 80% with %RSD < 6% in three studied sample matrices (wet tissue, shampoo and cream) at three different spiked levels. The method was applied to determine MI and MCI in 84 PCPs (shampoo, shower gel, cream, etc.) purchased in Ho Chi Minh City, Vietnam from March to July in 2021. MI and MCI were detected in some PCPs.

EMOLLIENTS IN ATOPIC DERMATITIS TREATMENT IN CHILDREN: CLINICAL AND PHARMACO-ECONOMICAL EFFICACY ANALYSIS

Background. Even the mild course of atopic dermatitis (AD) requires the complex approach to the exacerbation therapy and prevention. Systematic skin care is the cornerstone of AD antirelapse therapy, but the emollients price might interfere the compliance. The study aim was to evaluate clinical effectiveness and pharmacoeconomics of therapeutic skin care complex Atopic (daily cream, reliver cream and shower gel) in children with AtD. Materials and methods. Open prospective evaluation of 1-month long. There were 50 children (6 month to 18 years old) with AtD included in 2 groups (exacerbation and remission, 25 children each). We have evaluated mean values of SCORAD index, skin itching and dryness (visual analog scales), pharmacotherapy requests and number of AtD exacerbations. Emollients’ consumption was determined by used packs’ weighting. Month total emollients’ outlay and 1 remission day cost with the Atopic therapeutic skin care complex application were calculated. Results. 47 patients (94%) had completed the protocol; 3 children had stopped Atopic applications due to individual intolerance. After 1 month in AtD exacerbation group mean SCORAD-index score had decreased from 41,8±4,6 to 13,4±2,7 (р=0,0001); in remission group initially low SCORAD results (7,2±0,9) hadn’t changed (6,3±1,8). Among outlay subgroups the daily cream cost was predominant. Mean 1 remission day cost was 72.9 and 52.4 rubles/day for groups 1 and 2, respectively. Conclusions. Gathered data allow to characterize Atopic complex as attractive quality/price ratio cosmetics and to recommend their wide usage in long-term anti-relapse AtD therapy in children.

ANALISA SENSITIVITAS RESPON KONSUMEN DARI EKSTENSIFIKASI MEREK (BRAND EXTENSION) PADA SABUN MANDI CAIR MEREK CITRA (Studi pada Mahasiswa Universitas Muhammadiyah Purwokerto)

The success stems soap brand image in the market can lead consumers to buy shower gel Citra brand image. Shower gel Citra brand image is the result of the expansion of the brand (brand extension) conducted by PT. Unilever Indonesia from old products, namely soap rod Citra brand image. The results showed that consumers are sensitive to the presence of soap brand extension rod for shower gel and direction of consumer response showed positive results of toilet soap brand extension rod Citra brand image to shower gel Citra brand image with a sensitivity of 2.27. Changes in brand extension stimuli (brand extension) of soap rod brand image to shower gel brand image based on product attributes and Hierarcy stages of addressing the effect of positive values 321. A positive value shows that the stimuli are attached to the liquid bath soap brand image got a higher response from consumers in comparing stem bath soap brand image that has long existed before. Keywords: sensitivity, response, brand extension.