With the considerable use of high-grade pipeline steel in onshore and offshore project, welded joints are recognized as the weak link in pipeline because of the non-uniform microstructural regions induced by welding heat input. At first, the microstructural of different regions in API X80 pipeline welded joints was characterized and quantified by SEM, which indicate that the pipeline steel is a typical acicular ferrite steel. In this paper we investigated the J-integral resistance curve (J-R curve) in different locations of API X80 pipeline welded joints through low constraint SENT specimens with side grooves at room temperature. The effect of notch orientation (longitudinal-radial (L-R) and transverse-radial (T-R)) on resistance curve were investigated in base metal, which reveal the orientation almost have no effect on resistance curve. As the welded joints adopted in this study is two-pass steel arc welds, so the J-R curves of the inner surface, the outer surface and through-thickness surface notches specimens in the weld metal were investigated. The inner surface sample have the highest toughness through three samples because of the effect of second pass welding process. The effect of constraint on resistance curve was conduct between low constraint SENT specimen and high constraint SENB specimen, which found that the lower constraint corresponding to the higher resistance curve. After finishing the test, crack advancing plan of different positions were etched and observed by OM to demonstrate that the crack path always in the region which we would like to test.