Iyengar Yoga Therapy Intervention for Ischial Pressure Ulcers in a Patient with Amyotrophic Lateral Sclerosis: A Case Study

This chapter combines insights from the neuroscientific research on yoga and meditation with the practical application of yoga therapy. The chapter opens with an overview of neuroscientific concepts related to the practice of yoga and meditation, such as attention, emotional regulation, body awareness, and autonomic regulation. The authors summarise the known effects of yoga and meditation, in relation to these concepts and common mental health disorders. The chapter continues with a case study, a personalised yoga therapy intervention in a client experiencing psychotic symptoms. The intervention is grounded in yoga philosophy, and in the neuroscientific concepts introduced previously. This section is written from the perspective of a yoga therapist and includes practical tips. In the final section, the authors suggest possible directions for future research and implementation of yoga therapy as a complementary treatment in mental healthcare.

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Novel trends in orphan market drug discovery: amyotrophic lateral sclerosis as a case study

Frontiers in Bioscience ◽

10.2741/clark1 ◽

2002 ◽

Vol 7 (1-3) ◽

pp. c83 ◽

Cited By ~ 2

Author(s):

Jennifer, E. Clark

Keyword(s):

Amyotrophic Lateral Sclerosis ◽

Drug Discovery ◽

Lateral Sclerosis

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A case study of an emerging visual artist with frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Neurocase ◽

10.4324/9781003059790-7 ◽

2020 ◽

pp. 235-247

Author(s):

Anli Liu ◽

Kelly Werner ◽

Subhojit Roy ◽

John Q. Trojanowski ◽

Ursula Morgan-Kane ◽

...

Keyword(s):

Amyotrophic Lateral Sclerosis ◽

Frontotemporal Lobar Degeneration ◽

Visual Artist ◽

Lateral Sclerosis

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A Case Study on the Use of Trihexyphenidyl, Korean Medical Treatment for the Control of Sialorrhea in Patients with Amyotrophic Lateral Sclerosis(ALS)

The Acupuncture ◽

10.13045/kamms.2013016 ◽

2013 ◽

Vol 30 (2) ◽

pp. 73-79 ◽

Cited By ~ 1

Author(s):

Ho Hyun Jeong ◽

Sung Ha Kim ◽

Sang Mi Lee ◽

Jong Chul Lee ◽

Man Young Park ◽

...

Keyword(s):

Amyotrophic Lateral Sclerosis ◽

Medical Treatment ◽

Lateral Sclerosis

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From Riluzole to Dexpramipexole via Substituted-Benzothiazole Derivatives for Amyotrophic Lateral Sclerosis Disease Treatment: Case Studies

Molecules ◽

10.3390/molecules25153320 ◽

2020 ◽

Vol 25 (15) ◽

pp. 3320

Author(s):

Serge Mignani ◽

Jean-Pierre Majoral ◽

Jean-François Desaphy ◽

Giovanni Lentini

Keyword(s):

Amyotrophic Lateral Sclerosis ◽

Structural Analog ◽

Interesting Case ◽

Scaffold Hopping ◽

Disease Treatment ◽

Benzothiazole Derivatives ◽

Great Hope ◽

Diagnostic Agents ◽

Lateral Sclerosis

The 1,3-benzothiazole (BTZ) ring may offer a valid option for scaffold-hopping from indole derivatives. Several BTZs have clinically relevant roles, mainly as CNS medicines and diagnostic agents, with riluzole being one of the most famous examples. Riluzole is currently the only approved drug to treat amyotrophic lateral sclerosis (ALS) but its efficacy is marginal. Several clinical studies have demonstrated only limited improvements in survival, without benefits to motor function in patients with ALS. Despite significant clinical trial efforts to understand the genetic, epigenetic, and molecular pathways linked to ALS pathophysiology, therapeutic translation has remained disappointingly slow, probably due to the complexity and the heterogeneity of this disease. Many other drugs to tackle ALS have been tested for 20 years without any success. Dexpramipexole is a BTZ structural analog of riluzole and was a great hope for the treatment of ALS. In this review, as an interesting case study in the development of a new medicine to treat ALS, we present the strategy of the development of dexpramipexole, which was one of the most promising drugs against ALS.

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