Self-Assembled Nanomicelles to Enhance Solubility and Anticancer Activity of Etoposide

2021 ◽  
Author(s):  
Abdullah Alsalhi ◽  
Navid J. Ayon ◽  
Sadia Sikder ◽  
Bi-Botti C. Youan
Keyword(s):  
Anticancer Activity ◽  
Self Assembled

scholarly journals A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro

Nanomaterials ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 860 ◽  
Author(s):  
Ji Chen ◽  
Guotao Li ◽  
Qihong Liu ◽  
Yan Liang ◽  
Miaochang Liu ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Laser Irradiation ◽  
Pharmacological Action ◽  
Coumarin Derivative ◽  
Intracellular Uptake ◽  
Release Behavior ◽  
Triggered Drug Release ◽  
Self Assembled ◽  
Clinical Drug

Accelerating degradation of prodrug is an effective strategy for improving the pharmacological action. A photocleavable amphiphilic prodrug of methotrexate-coumarin derivative-PEG conjugates (MTX-AMC-PEG) with photo-triggered breakage to release clinical drug under laser irradiation was fabricated and self-assembled into nanoparticles for chemotherapy. The nanoparticles exhibited good intracellular uptake and excellent photolysis release of MTX, which resulted in efficient anticancer activity in vitro with laser irradiation. This research provides a way to fabricate photocleavable prodrug nanoparticles with stimuli-triggered drug release behavior.

Simple and Multifunctional Natural Self-Assembled Sterols with Anticancer Activity-Mediated Supramolecular Photosensitizers for Enhanced Antitumor Photodynamic Therapy

2019 ◽  
Vol 11 (33) ◽  
pp. 29498-29511 ◽  
Author(s):  
Jianjun Cheng ◽  
Haitian Zhao ◽  
Lei Yao ◽  
Yang Li ◽  
Baokun Qi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Anticancer Activity ◽  
Self Assembled

scholarly journals Self-Assembled Palladium and Platinum Coordination Cages: Photophysical Studies and Anticancer Activity

2016 ◽  
Vol 2016 (33) ◽  
pp. 5189-5196 ◽  
Author(s):  
Felix Kaiser ◽  
Andrea Schmidt ◽  
Wolfgang Heydenreuter ◽  
Philipp J. Altmann ◽  
Angela Casini ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Coordination Cages ◽  
Photophysical Studies ◽  
Self Assembled

scholarly journals Front Cover: Self-Assembled Palladium and Platinum Coordination Cages: Photophysical Studies and Anticancer Activity (Eur. J. Inorg. Chem. 33/2016)

2016 ◽  
Vol 2016 (33) ◽  
pp. 5180-5180
Author(s):  
Felix Kaiser ◽  
Andrea Schmidt ◽  
Wolfgang Heydenreuter ◽  
Philipp J. Altmann ◽  
Angela Casini ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Front Cover ◽  
Coordination Cages ◽  
Photophysical Studies ◽  
Self Assembled

Cationic drug-based self-assembled polyelectrolyte complex micelles: Physicochemical, pharmacokinetic, and anticancer activity analysis

2016 ◽  
Vol 146 ◽  
pp. 152-160 ◽  
Author(s):  
Thiruganesh Ramasamy ◽  
Bijay Kumar Poudel ◽  
Himabindu Ruttala ◽  
Ju Yeon Choi ◽  
Truong Duy Hieu ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Polyelectrolyte Complex ◽  
Activity Analysis ◽  
Self Assembled ◽  
Complex Micelles

scholarly journals Combretastatin A4-camptothecin micelles as combination therapy for effective anticancer activity

RSC Advances ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 1055-1061 ◽  
Author(s):  
Mohyeddin Assali ◽  
Naim Kittana ◽  
Sahar Alhaj Qasem ◽  
Raghad Adas ◽  
Doaa Saleh ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Normal Cells ◽  
Micelle Structure ◽  
Combretastatin A4 ◽  
Self Assembled

Novel CA4-TEG-triazole-TEG-Cpt (codrug 9) was synthesized and self-assembled into a micelle structure that showed a great synergistic anticancer activity on HeLa cancer cells without affecting the viability of 3T3 normal cells.

Anticancer Activity and Autophagy Involvement of Self-Assembled Arene–Ruthenium Metallacycles

2015 ◽  
Vol 34 (18) ◽  
pp. 4507-4514 ◽  
Author(s):  
Abhishek Dubey ◽  
Yong Joon Jeong ◽  
Jae Ho Jo ◽  
Sangkook Woo ◽  
Dong Hwan Kim ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Self Assembled

scholarly journals Self-Assembled Palladium and Platinum Coordination Cages: Photophysical Studies and Anticancer Activity

2016 ◽  
Vol 2016 (33) ◽  
pp. 5181-5181 ◽  
Author(s):  
Felix Kaiser ◽  
Andrea Schmidt ◽  
Wolfgang Heydenreuter ◽  
Philipp J. Altmann ◽  
Angela Casini ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Coordination Cages ◽  
Photophysical Studies ◽  
Self Assembled

scholarly journals Anticancer Activity of Self-Assembled Molecular Rectangles via Arene–Ruthenium Acceptors and a New Unsymmetrical Amide Ligand

2012 ◽  
Vol 31 (9) ◽  
pp. 3519-3526 ◽  
Author(s):  
Anurag Mishra ◽  
Hyunji Jung ◽  
Jeong Woo Park ◽  
Hong Kyeung Kim ◽  
Hyunuk Kim ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Self Assembled

Improving anticancer activity and reducing systemic toxicity of doxorubicin by self-assembled polymeric micelles

2011 ◽  
Vol 22 (9) ◽  
pp. 095102 ◽  
Author(s):  
MaLing Gou ◽  
HuaShan Shi ◽  
Gang Guo ◽  
Ke Men ◽  
Juan Zhang ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Polymeric Micelles ◽  
Systemic Toxicity ◽  
Self Assembled
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