Simple and Multifunctional Natural Self-Assembled Sterols with Anticancer Activity-Mediated Supramolecular Photosensitizers for Enhanced Antitumor Photodynamic Therapy

2019 ◽  
Vol 11 (33) ◽  
pp. 29498-29511 ◽  
Author(s):  
Jianjun Cheng ◽  
Haitian Zhao ◽  
Lei Yao ◽  
Yang Li ◽  
Baokun Qi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Anticancer Activity ◽  
Self Assembled

scholarly journals Pheophorbide a: State of the Art

Marine Drugs ◽  
2020 ◽  
Vol 18 (5) ◽  
pp. 257 ◽  
Author(s):  
Assunta Saide ◽  
Chiara Lauritano ◽  
Adrianna Ianora
Keyword(s):  
Clinical Trials ◽  
Photodynamic Therapy ◽  
Anticancer Activity ◽  
State Of The Art ◽  
Human Cancer ◽  
Human Cancer Cell ◽  
Pheophorbide A ◽  
Human Cancer Cell Lines ◽  
Chlorophyll Breakdown ◽  
Chlorophyll Derivative

Chlorophyll breakdown products are usually studied for their antioxidant and anti-inflammatory activities. The chlorophyll derivative Pheophorbide a (PPBa) is a photosensitizer that can induce significant anti-proliferative effects in several human cancer cell lines. Cancer is a leading cause of death worldwide, accounting for about 9.6 million deaths, in 2018 alone. Hence, it is crucial to monitor emergent compounds that show significant anticancer activity and advance them into clinical trials. In this review, we analyze the anticancer activity of PPBa with or without photodynamic therapy and also conjugated with or without other chemotherapic drugs, highlighting the capacity of PPBa to overcome multidrug resistance. We also report other activities of PPBa and different pathways that it can activate, showing its possible applications for the treatment of human pathologies.

Self-assembled gold nanostar–NaYF4:Yb/Er clusters for multimodal imaging, photothermal and photodynamic therapy

2016 ◽  
Vol 4 (25) ◽  
pp. 4455-4461 ◽  
Author(s):  
Liangcan He ◽  
Joseph Dragavon ◽  
Suehyun Cho ◽  
Chenchen Mao ◽  
Adem Yildirim ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Multimodal Imaging ◽  
Grand Challenge ◽  
Gold Nanostar ◽  
Self Assembled

A grand challenge for medicine is to develop tools to selectively image and treat diseased cells.

scholarly journals A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro

Nanomaterials ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 860 ◽  
Author(s):  
Ji Chen ◽  
Guotao Li ◽  
Qihong Liu ◽  
Yan Liang ◽  
Miaochang Liu ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Laser Irradiation ◽  
Pharmacological Action ◽  
Coumarin Derivative ◽  
Intracellular Uptake ◽  
Release Behavior ◽  
Triggered Drug Release ◽  
Self Assembled ◽  
Clinical Drug

Accelerating degradation of prodrug is an effective strategy for improving the pharmacological action. A photocleavable amphiphilic prodrug of methotrexate-coumarin derivative-PEG conjugates (MTX-AMC-PEG) with photo-triggered breakage to release clinical drug under laser irradiation was fabricated and self-assembled into nanoparticles for chemotherapy. The nanoparticles exhibited good intracellular uptake and excellent photolysis release of MTX, which resulted in efficient anticancer activity in vitro with laser irradiation. This research provides a way to fabricate photocleavable prodrug nanoparticles with stimuli-triggered drug release behavior.

Dual activatable self-assembled nanotheranostics for bioimaging and photodynamic therapy

2020 ◽  
Vol 327 ◽  
pp. 129-139
Author(s):  
Yan Fu ◽  
Moon-Sun Jang ◽  
Nannan Wang ◽  
Yi Li ◽  
Te Peng Wu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Self Assembled

scholarly journals Self-Assembled Palladium and Platinum Coordination Cages: Photophysical Studies and Anticancer Activity

2016 ◽  
Vol 2016 (33) ◽  
pp. 5189-5196 ◽  
Author(s):  
Felix Kaiser ◽  
Andrea Schmidt ◽  
Wolfgang Heydenreuter ◽  
Philipp J. Altmann ◽  
Angela Casini ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Coordination Cages ◽  
Photophysical Studies ◽  
Self Assembled

scholarly journals Self-assembled liposomal nanoparticles in photodynamic therapy

2013 ◽  
Vol 5 (3) ◽  
Author(s):  
Magesh Sadasivam ◽  
Pinar Avci ◽  
Gaurav K. Gupta ◽  
Shanmugamurthy Lakshmanan ◽  
Rakkiyappan Chandran ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Self Assembly ◽  
Building Blocks ◽  
Dimensional Structure ◽  
3 Dimensional ◽  
Drug Delivery Vehicles ◽  
Judicious Choice ◽  
Delivery Vehicles ◽  
Self Assembled ◽  
Liposomal Nanoparticles

AbstractPhotodynamic therapy (PDT) employs the combination of non-toxic photosensitizers (PS) together with harmless visible light of the appropriate wavelength to produce reactive oxygen species that kill unwanted cells. Because many PS are hydrophobic molecules prone to aggregation, numerous drug delivery vehicles have been tested to solubilize these molecules, render them biocompatible and enhance the ease of administration after intravenous injection. The recent rise in nanotechnology has markedly expanded the range of these nanoparticulate delivery vehicles beyond the well-established liposomes and micelles. Self-assembled nanoparticles are formed by judicious choice of monomer building blocks that spontaneously form a well-oriented 3-dimensional structure that incorporates the PS when subjected to the appropriate conditions. This self-assembly process is governed by a subtle interplay of forces on the molecular level. This review will cover the state of the art in the preparation and use of self-assembled liposomal nanoparticles within the context of PDT.

scholarly journals A self-assembled cyclodextrin nanocarrier for photoreactive squaraine

2016 ◽  
Vol 12 ◽  
pp. 2535-2542 ◽  
Author(s):  
Ulrike Kauscher ◽  
Bart Jan Ravoo
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Spectroscopy ◽  
Absorption Spectroscopy ◽  
Photochemical Activity ◽  
Oxygen Species ◽  
Significant Potential ◽  
Self Assembled

Photoreactive squaraines produce cytotoxic oxygen species under irradiation and have significant potential for photodynamic therapy. Herein we report that squaraines can be immobilized on a self-assembled nanocarrier composed of amphiphilic cyclodextrins to enhance their photochemical activity. To this end, a squaraine was equipped with two adamantane moieties that act as anchors for the cyclodextrin vesicle surface. The supramolecular immobilization was monitored by using fluorescence spectroscopy and microscopy and the photochemistry of the squaraine was investigated by using absorption spectroscopy.

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