Analysis of Near Full-Length Genome Sequences of HIV Type 1 BF Intersubtype Recombinant Viruses from Brazil Reveals Their Independent Origins and Their Lack of Relationship to CRF12_BF

2004 ◽  
Vol 20 (10) ◽  
pp. 1126-1133 ◽  
Author(s):  
Michael M. Thomson ◽  
María Sierra ◽  
Amilcar Tanuri ◽  
Silvia May ◽  
Gema Casado ◽  
...  
2012 ◽  
Vol 28 (10) ◽  
pp. 1340-1343 ◽  
Author(s):  
Aurora Fernández-García ◽  
Ana Revilla ◽  
Elena Vázquez-de Parga ◽  
Anna Vinogradova ◽  
Aza Rakhmanova ◽  
...  

2002 ◽  
Vol 83 (1) ◽  
pp. 107-119 ◽  
Author(s):  
Michael M. Thomson ◽  
Elena Delgado ◽  
Isabel Herrero ◽  
María Luisa Villahermosa ◽  
Elena Vázquez-de Parga ◽  
...  

The findings that BF intersubtype recombinant human immunodeficiency type 1 viruses (HIV-1) with coincident breakpoints in pol are circulating widely in Argentina and that non-recombinant F subtype viruses have failed to be detected in this country were reported recently. To analyse the mosaic structures of these viruses and to determine their phylogenetic relationship, near full-length proviral genomes of eight of these recombinant viruses were amplified by PCR and sequenced. Intersubtype breakpoints were analysed by bootscanning and examining the signature nucleotides. Phylogenetic relationships were determined with neighbour-joining trees. Five viruses, each with predominantly subtype F genomes, exhibited mosaic structures that were highly similar. Two intersubtype breakpoints were shared by all viruses and seven by the majority. Of the consensus breakpoints, all nine were present in two viruses, which exhibited identical recombinant structures, and four to eight breakpoints were present in the remaining viruses. Phylogenetic analysis of partial sequences supported both a common ancestry, at least in part of their genomes, for all recombinant viruses and the phylogenetic relationship of F subtype segments with F subtype viruses from Brazil. A common ancestry of the recombinants was supported also by the presence of shared signature amino acids and nucleotides, either unreported or highly unusual in F and B subtype viruses. These results indicate that HIV-1 BF recombinant viruses with diverse mosaic structures, including a circulating recombinant form (which are widespread in Argentina) derive from a common recombinant ancestor and that F subtype segments of these recombinants are related phylogenetically to the F subtype viruses from Brazil.


2003 ◽  
Vol 19 (8) ◽  
pp. 719-725 ◽  
Author(s):  
Gema Casado ◽  
Michael M Thomson ◽  
Elena Delgado ◽  
María Sierra ◽  
Elena Vázquez-de Parga ◽  
...  

2001 ◽  
Vol 17 (12) ◽  
pp. 1211-1216 ◽  
Author(s):  
Coumba Toure Kane ◽  
Celine Montavon ◽  
Mama Awa Toure ◽  
Mame Awa Faye ◽  
Aissatou Gueye Ndiaye ◽  
...  

2011 ◽  
Vol 27 (8) ◽  
pp. 911-915 ◽  
Author(s):  
Benson C. Iweriebor ◽  
Pascal O. Bessong ◽  
Lufuno G. Mavhandu ◽  
Tracy M. Masebe ◽  
Julius Nwobegahay ◽  
...  

2007 ◽  
Vol 23 (2) ◽  
pp. 297-302 ◽  
Author(s):  
Ka-Cheung Luk ◽  
Vera Holzmayer ◽  
Julie Yamaguchi ◽  
Priscilla Swanson ◽  
Catherine A. Brennan ◽  
...  

2009 ◽  
Vol 25 (11) ◽  
pp. 1187-1191 ◽  
Author(s):  
Aurora Fernández-García ◽  
María Teresa Cuevas ◽  
Anna Vinogradova ◽  
Aza Rakhmanova ◽  
Lucía Pérez-Álvarez ◽  
...  

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