scholarly journals Unusual Insertion and Deletion at Codon 67 and 69 of HIV Type 1 Subtype C Reverse Transcriptase Among First-Line Highly Active Antiretroviral Treatment-Failing South Indian Patients: Association with Other Resistance Mutations

2012 ◽  
Vol 28 (12) ◽  
pp. 1763-1765 ◽  
Author(s):  
Shanmugam Saravanan ◽  
Vidya Madhavan ◽  
Rami Kantor ◽  
Sathasivam Sivamalar ◽  
Selvamurthi Gomathi ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Antiretroviral Treatment ◽  
Resistance Mutations ◽  
Subtype C ◽  
First Line ◽  
Highly Active ◽  
Insertion And Deletion ◽  
South Indian ◽  
Hiv Type 1

scholarly journals Impact of HIV Type 1 Subtype on Drug Resistance Mutations in Nigerian Patients Failing First-Line Therapy

2011 ◽  
Vol 27 (1) ◽  
pp. 71-80 ◽  
Author(s):  
B. Chaplin ◽  
G. Eisen ◽  
J. Idoko ◽  
D. Onwujekwe ◽  
E. Idigbe ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Resistance Mutations ◽  
First Line ◽  
Drug Resistance Mutations ◽  
First Line Therapy ◽  
Line Therapy ◽  
Hiv Type 1

scholarly journals High Frequency of Syncytium-Inducing and CXCR4-Tropic Viruses among Human Immunodeficiency Virus Type 1 Subtype C-Infected Patients Receiving Antiretroviral Treatment

2003 ◽  
Vol 77 (13) ◽  
pp. 7682-7688 ◽  
Author(s):  
Elizabeth R. Johnston ◽  
Lynn S. Zijenah ◽  
Solomon Mutetwa ◽  
Rami Kantor ◽  
Chonticha Kittinunvorakoon ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Antiretroviral Treatment ◽  
Mononuclear Cells ◽  
Resistance Mutations ◽  
Subtype C ◽  
Peripheral Blood Mononuclear ◽  
Immunodeficiency Virus

ABSTRACT Human immunodeficiency virus type 1 (HIV-1) subtype C viruses have been found to almost exclusively use the chemokine receptor CCR5 as a coreceptor for entry, even in patients with advanced AIDS. We have characterized subtype C virus isolates from 28 patients from Harare, Zimbabwe, 20 of whom were receiving antiretroviral treatment. Virus from 10 of the treated patients induced syncytium formation (SI virus) when cultured with MT2 cells. Only non-syncytium-inducing (NSI) virus was cultured from the peripheral blood mononuclear cells of the eight patients who had not received treatment. The majority of these subtype C SI viruses were capable of using both CCR5 and CXCR4 as coreceptors for viral entry, and the consensus V3 loop sequences from the SI viruses displayed a high net charge compared to those of NSI viruses. While those on treatment had reverse transcriptase (RT) and protease mutations, there was no clear association between RT and protease drug resistance mutations and coreceptor tropism. These results suggest that CXCR4-tropic viruses are present within the quasispecies of patients infected with subtype C virus and that antiretroviral treatment may create an environment for the emergence of CXCR4 tropism.

Detection of Low-Frequency HIV Type 1 Reverse Transcriptase Drug Resistance Mutations by Ultradeep Sequencing in Naive HIV Type 1-Infected individuals

2014 ◽  
Vol 30 (2) ◽  
pp. 170-173 ◽  
Author(s):  
Pantxika Bellecave ◽  
Patricia Recordon-Pinson ◽  
Jennifer Papuchon ◽  
Marie-Anne Vandenhende ◽  
Sandrine Reigadas ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Reverse Transcriptase ◽  
Low Frequency ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Hiv Type 1

scholarly journals Drug Resistance Mutations in Drug-Naive HIV Type 1 Subtype C-Infected Individuals from Rural Malawi

2011 ◽  
Vol 27 (4) ◽  
pp. 439-444 ◽  
Author(s):  
Vijay Bansode ◽  
Zuzanna J. Drebert ◽  
Simon A.A. Travers ◽  
Emmanuel Banda ◽  
Anna Molesworth ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Resistance Mutations ◽  
Subtype C ◽  
Drug Resistance Mutations ◽  
Drug Naïve ◽  
Hiv Type 1

Genotypic Analysis of the Protease and Reverse Transcriptase of HIV Type 1 Subtype C Isolates from Antiretroviral Drug-Naive Adults in Malawi

2005 ◽  
Vol 21 (9) ◽  
pp. 799-805 ◽  
Author(s):  
L.A. Petch ◽  
I.F. Hoffman ◽  
C.S. Jere ◽  
P.N. Kazembe ◽  
F.E. Martinson ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Subtype C ◽  
Antiretroviral Drug ◽  
Genotypic Analysis ◽  
Drug Naïve ◽  
Hiv Type 1

Analysis of RT Sequences of Subtype C HIV-Type 1 Isolates from Indian Patients at Failure of a First-Line Treatment According to Clinical and/or Immunological WHO Guidelines

2010 ◽  
Vol 26 (3) ◽  
pp. 343-350 ◽  
Author(s):  
Alaka Deshpande ◽  
Anne Cécile Jeannot ◽  
Marie Hélène Schrive ◽  
Linda Wittkop ◽  
Patricia Pinson ◽  
...  
Keyword(s):  
Line Treatment ◽  
Who Guidelines ◽  
Subtype C ◽  
First Line ◽  
Indian Patients ◽  
Hiv Type 1 ◽  
First Line Treatment
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