The Neuroprotective Effect of the Adiponectin Receptor Agonist AdipoRon on Glutamate-Induced Cell Death in Rat Primary Retinal Ganglion Cells

2019 ◽  
Vol 35 (10) ◽  
pp. 535-541
Author(s):  
Takatoshi Uchida ◽  
Takashi Ueta ◽  
Megumi Honjo ◽  
Makoto Aihara
Keyword(s):  
Cell Death ◽  
Retinal Ganglion Cells ◽  
Receptor Agonist ◽  
Ganglion Cells ◽  
Neuroprotective Effect ◽  
Adiponectin Receptor ◽  
Retinal Ganglion

scholarly journals Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Michal Geva ◽  
Noga Gershoni-Emek ◽  
Luana Naia ◽  
Philip Ly ◽  
Sandra Mota ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Degeneration ◽  
Retinal Ganglion Cells ◽  
Retinal Ganglion Cell ◽  
Ganglion Cells ◽  
Neuroprotective Effect ◽  
Retinal Ganglion ◽  
Cell Degeneration ◽  
Sigma 1 Receptor ◽  
Sigma 1

AbstractOptic neuropathies such as glaucoma are characterized by retinal ganglion cell (RGC) degeneration and death. The sigma-1 receptor (S1R) is an attractive target for treating optic neuropathies as it is highly expressed in RGCs, and its absence causes retinal degeneration. Activation of the S1R exerts neuroprotective effects in models of retinal degeneration. Pridopidine is a highly selective and potent S1R agonist in clinical development. We show that pridopidine exerts neuroprotection of retinal ganglion cells in two different rat models of glaucoma. Pridopidine strongly binds melanin, which is highly expressed in the retina. This feature of pridopidine has implications to its ocular distribution, bioavailability, and effective dose. Mitochondria dysfunction is a key contributor to retinal ganglion cell degeneration. Pridopidine rescues mitochondrial function via activation of the S1R, providing support for the potential mechanism driving its neuroprotective effect in retinal ganglion cells.

Low dosage chloroquine protects retinal ganglion cells against glutamate-induced cell death

2019 ◽  
Vol 181 ◽  
pp. 285-293 ◽  
Author(s):  
Xiaoyun Ma ◽  
Yun Zhang ◽  
Dan Zhu ◽  
Zufeng Chen ◽  
Manshan Xu ◽  
...  
Keyword(s):  
Cell Death ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Low Dosage

N-acetylated-α-linked-acidic dipeptidase inhibitor has a neuroprotective effect on mouse retinal ganglion cells after pressure-induced ischemia

2000 ◽  
Vol 292 (2) ◽  
pp. 134-136 ◽  
Author(s):  
Chikako Harada ◽  
Takayuki Harada ◽  
Barbara S Slusher ◽  
Kazuhiko Yoshida ◽  
Hidehiko Matsuda ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Neuroprotective Effect ◽  
Retinal Ganglion

Neuroprotection by GH against excitotoxic-induced cell death in retinal ganglion cells

2016 ◽  
Vol 234 ◽  
pp. 68-80 ◽  
Author(s):  
Carlos G. Martínez-Moreno ◽  
José Ávila-Mendoza ◽  
Yilun Wu ◽  
Elvira del Carmen Arellanes-Licea ◽  
Marcela Louie ◽  
...  
Keyword(s):  
Cell Death ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion

Neuroprotective effect of erythropoietin-loaded composite microspheres on retinal ganglion cells in rats

2011 ◽  
Vol 43 (4) ◽  
pp. 334-342 ◽  
Author(s):  
Xianfang Rong ◽  
Xiaofen Mo ◽  
Tiantian Ren ◽  
Sixing Yang ◽  
Weien Yuan ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Neuroprotective Effect ◽  
Retinal Ganglion ◽  
Composite Microspheres

Neuroprotective effect of alpha-lipoic acid on hydrostatic pressure-induced damage of retinal ganglion cells in vitro

2012 ◽  
Vol 526 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Bing Liu ◽  
Xiaohua Ma ◽  
Dadong Guo ◽  
Yuanyuan Guo ◽  
Ninghong Chen ◽  
...  
Keyword(s):  
Hydrostatic Pressure ◽  
Retinal Ganglion Cells ◽  
Lipoic Acid ◽  
Ganglion Cells ◽  
Neuroprotective Effect ◽  
Retinal Ganglion ◽  
Alpha Lipoic Acid
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