Locomotor Deficits and Adaptive Mechanisms after Thoracic Spinal Cord Contusion in the Adult Rat

2006 ◽  
Vol 23 (1) ◽  
pp. 1-17 ◽  
Author(s):  
Jorge E. Collazos-Castro ◽  
Elisa López-Dolado ◽  
Manuel Nieto-Sampedro
Keyword(s):  
Spinal Cord ◽  
Thoracic Spinal Cord ◽  
Adult Rat ◽  
Thoracic Spinal ◽  
Adaptive Mechanisms ◽  
Locomotor Deficits ◽  
Spinal Cord Contusion

Transient decrease of acetylcholinesterase in ventral horn neurons caudal to a low thoracic spinal cord hemisection in the adult rat

1996 ◽  
Vol 714 (1-2) ◽  
pp. 177-184 ◽  
Author(s):  
Wilhelm Nacimiento ◽  
Bernd Schlözer ◽  
Gary A. Brook ◽  
Lajos Tóth ◽  
Rudolf Töpper ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Ventral Horn ◽  
Thoracic Spinal Cord ◽  
Adult Rat ◽  
Transient Decrease ◽  
Thoracic Spinal ◽  
Spinal Cord Hemisection

scholarly journals Schwann Cell But Not Olfactory Ensheathing Glia Transplants Improve Hindlimb Locomotor Performance in the Moderately Contused Adult Rat Thoracic Spinal Cord

2002 ◽  
Vol 22 (15) ◽  
pp. 6670-6681 ◽  
Author(s):  
Toshihiro Takami ◽  
Martin Oudega ◽  
Margaret L. Bates ◽  
Patrick M. Wood ◽  
Naomi Kleitman ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Schwann Cell ◽  
Locomotor Performance ◽  
Thoracic Spinal Cord ◽  
Adult Rat ◽  
Thoracic Spinal ◽  
Olfactory Ensheathing Glia

Effects of epidural hypothermic saline infusion on locomotor outcome and tissue preservation after moderate thoracic spinal cord contusion in rats

2005 ◽  
Vol 2 (3) ◽  
pp. 308-318 ◽  
Author(s):  
Carlos E. Casas ◽  
Loren P. Herrera ◽  
Chad Prusmack ◽  
Gladys Ruenes ◽  
Alexander Marcillo ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Gray Matter ◽  
Thoracic Spinal Cord ◽  
Content Type ◽  
Treatment Groups ◽  
Thoracic Spinal ◽  
Cord Injury ◽  
Spinal Cord Contusion ◽  
Tissue Sparing ◽  
Fine Print

Object. Regionally delivered hypothermia has advantages over systemic hypothermia for clinical application following spinal cord injury (SCI). The effects of local hypothermia on tissue sparing, neuronal preservation, and locomotor outcome were studied in a moderate thoracic spinal cord contusion model. Methods. Rats were randomized to four treatment groups and data were collected and analyzed in a blinded fashion. Chilled saline was perfused into the epidural space 30 minutes postcontusion to achieve the following epidural temperatures: 24 ± 2.3°C (16 rats), 30 ± 2.4°C (13 rats), and 35 ± 0.9°C (13 rats). Hypothermia was continued for 3 hours when a 45-minute period of rewarming was instituted. In a fourth group a moderate contusion only was induced in 14 animals. Rectal (core) and T9–10 (epidural) temperatures were measured continuously. Locomotor testing, using the Basso-Beattie-Bresnahan (Ba-Be-Br) scale, was performed for 6 weeks, and rats were videotaped for subsequent analysis. The lesion/preserved tissue ratio was calculated throughout the entire lesion cavity and the total lesion, spinal cord, and spared tissue volumes were determined. The rostral and caudal extent of gray matter loss was also measured. At 6 weeks locomotor recovery was similar in all groups (mean Ba-Be-Br Scale scores 14.88 ± 3.71, 14.83 ± 2.81, 14.50 ± 2.24, and 14.07 ± 2.39 [p = 0.77] for all four groups, respectively). No significant differences in spared tissue volumes were found when control and treatment groups were compared, but gray matter preservation was reduced in the infusion-treated groups. Conclusions. Regional cooling applied 30 minutes after a moderate contusive SCI was not beneficial in terms of tissue sparing, neuronal preservation, or locomotor outcome. This method of cooling may reduce blood flow in the injured spinal cord and exacerbate secondary injury.

Atorvastatin prevents early apoptosis after thoracic spinal cord contusion injury and promotes locomotion recovery

2009 ◽  
Vol 453 (1) ◽  
pp. 73-76 ◽  
Author(s):  
Marc-André Déry ◽  
Guy Rousseau ◽  
Mohamed Benderdour ◽  
Eric Beaumont
Keyword(s):  
Spinal Cord ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Contusion Injury ◽  
Early Apoptosis ◽  
Spinal Cord Contusion

scholarly journals Upregulation of TRESK Channels Contributes to Motor and Sensory Recovery after Spinal Cord Injury

2020 ◽  
Vol 21 (23) ◽  
pp. 8997
Author(s):  
Gyu-Tae Kim ◽  
Adrian S. Siregar ◽  
Eun-Jin Kim ◽  
Eun-Shin Lee ◽  
Marie Merci Nyiramana ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
K Channel ◽  
Thoracic Spinal Cord ◽  
Injury Site ◽  
Thoracic Spinal ◽  
Cord Injury ◽  
Spinal Cord Contusion ◽  
Pore Domain

TWIK (tandem-pore domain weak inward rectifying K+)-related spinal cord K+ channel (TRESK), a member of the two-pore domain K+ channel family, is abundantly expressed in dorsal root ganglion (DRG) neurons. It is well documented that TRESK expression is changed in several models of peripheral nerve injury, resulting in a shift in sensory neuron excitability. However, the role of TRESK in the model of spinal cord injury (SCI) has not been fully understood. This study investigates the role of TRESK in a thoracic spinal cord contusion model, and in transgenic mice overexpressed with the TRESK gene (TGTRESK). Immunostaining analysis showed that TRESK was expressed in the dorsal and ventral neurons of the spinal cord. The TRESK expression was increased by SCI in both dorsal and ventral neurons. TRESK mRNA expression was upregulated in the spinal cord and DRG isolated from the ninth thoracic (T9) spinal cord contusion rats. The expression was significantly upregulated in the spinal cord below the injury site at acute time points (6, 24, and 48 h) after SCI (p < 0.05). In addition, TRESK expression was markedly increased in DRGs below and adjacent to the injury site. TRESK was expressed in inflammatory cells. In addition, the number and fluorescence intensity of TRESK-positive neurons increased in the dorsal and ventral horns of the spinal cord after SCI. TGTRESK SCI mice showed faster paralysis recovery and higher mechanical threshold compared to wild-type (WT)-SCI mice. TGTRESK mice showed lower TNF-α concentrations in the blood than WT mice. In addition, IL-1β concentration and apoptotic signals in the caudal spinal cord and DRG were significantly decreased in TGTRESK SCI mice compared to WT-SCI mice (p < 0.05). These results indicate that TRESK upregulated following SCI contributes to the recovery of paralysis and mechanical pain threshold by suppressing the excitability of motor and sensory neurons and inflammatory and apoptotic processes.

Behavioral and anatomical consequences of repetitive mild thoracic spinal cord contusion injury in the rat

2014 ◽  
Vol 257 ◽  
pp. 57-69 ◽  
Author(s):  
Ying Jin ◽  
Julien Bouyer ◽  
Christopher Haas ◽  
Itzhak Fischer
Keyword(s):  
Spinal Cord ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Contusion Injury ◽  
Spinal Cord Contusion
Sign in / Sign up

Export Citation Format

Share Document