scholarly journals A Clinical Prediction Model for Long-Term Functional Outcome after Traumatic Spinal Cord Injury Based on Acute Clinical and Imaging Factors

2012 ◽  
Vol 29 (13) ◽  
pp. 2263-2271 ◽  
Author(s):  
Jefferson R. Wilson ◽  
Robert G. Grossman ◽  
Ralph F. Frankowski ◽  
Alexander Kiss ◽  
Aileen M. Davis ◽  
...  
Spinal Cord ◽  
2020 ◽  
Vol 58 (11) ◽  
pp. 1158-1165
Author(s):  
Yuto Ariji ◽  
Tetsuo Hayashi ◽  
Ryosuke Ideta ◽  
Ryuichiro Koga ◽  
Satoshi Murai ◽  
...  

Spine ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Thomas Liebscher ◽  
Johanna Ludwig ◽  
Tom Lübstorf ◽  
Martin Kreutzträger ◽  
Thomas Auhuber ◽  
...  

2014 ◽  
Vol 37 (16) ◽  
pp. 1401-1410 ◽  
Author(s):  
Donna Goodridge ◽  
Marla Rogers ◽  
Laura Klassen ◽  
Bonnie Jeffery ◽  
Katherine Knox ◽  
...  

2020 ◽  
Vol 33 (2) ◽  
pp. 256-260 ◽  
Author(s):  
Mette Haldrup ◽  
Stig Dyrskog ◽  
Mathias Møller Thygesen ◽  
Hans Kirkegaard ◽  
Helge Kasch ◽  
...  

OBJECTIVEPatients with traumatic spinal cord injury (TSCI) are at risk of developing neurogenic shock that causes hypotension and thereby secondary injury to the spinal cord due to ischemia. Hemodynamic treatment of patients with acute TSCI remains inadequately elucidated. Guidelines for management are divergent and based on limited evidence. To this end, the authors evaluated whether mean arterial blood pressure (MABP) during the prehospital and initial hospital phases of TSCI treatment is correlated with long-term neurological outcome.METHODSThe authors performed a retrospective cohort study based on a chart review of MABP data collected during the prehospital transport, in the operating room (OR), and in the neurointensive care unit (NICU) during the first 7 days after trauma. Data from the NICU were divided into two periods: days 1–2 and days 3–7. Data were analyzed using Spearman’s rank correlation to evaluate for any correlation between MABP and changes in the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) score 1 year postinjury. In the analysis, the MABP target value was 80 mm Hg. Hypotension was treated with metaoxedrin or norepinephrine. Statistically significant differences were evaluated using Spearman’s rank correlation coefficient.RESULTSThe chart review yielded 129 patients treated for TSCI. The inclusion period was 2010–2017. For the prehospital transport measurements of MABP, the Spearman’s rank correlation coefficient was a rho of 0.5662 (p < 0.001), for OR measurements it was a rho of 0.6818 (p < 0.001), and for the NICU measurements it was a rho of 0.4611 (p < 0.001); for NICU unit days 1–2 and days 3–7, the Spearman’s rank correlation coefficient was a rho of 0.2209 (p = 0.0681).CONCLUSIONSContinuous MABP levels exceeding 80 mm Hg have a significant impact on neurological outcome—from earliest possible stabilization in the prehospital care, through hospital admission, the surgical phase, and into the first 2 days in the NICU.


Surgery ◽  
2018 ◽  
Vol 164 (4) ◽  
pp. 705-711 ◽  
Author(s):  
Raymond P. Onders ◽  
MaryJo Elmo ◽  
Cindy Kaplan ◽  
Robert Schilz ◽  
Bashar Katirji ◽  
...  

2021 ◽  
Author(s):  
Sizheng Zhan ◽  
Boxuan Huang ◽  
Wenyong Xie ◽  
Feng Xue ◽  
Dianying Zhang ◽  
...  

Abstract Purpose: We aimed to construct a nonlinear regression model through Extreme Gradient Boost (XGBoost) to predict functional outcome 1 year after surgical decompression for patients with acute spinal cord injury (SCI).Methods: We prospectively enrolled 249 patients with acute SCI from 5 primary orthopedic centers from June 1, 2016, to June 1, 2020. We identified a total of 6 predictors with three aspects: 1) clinical characteristics, including age, American Spinal Injury Association (ASIA) Impairment Scale (AIS) at admission, level of injury and baseline ASIA motor score (AMS); 2) MR imaging, mainly including Brain and Spinal Injury Center (BASIC) score; 3) surgical timing, specifically comparing whether surgical decompression was received within 24 hours or not. We assessed the SCIM score at 1 year after the operation as the functional outcome index. XGBoost was used to build a nonlinear regression prediction model through the method of boosting integrated learning.Results: We successfully constructed a nonlinear regression prediction model through XGBoost and verified the credibility. The average absolute value of the difference between the predicted value and the actual value is 3.72 (t=1.29, P=0.203), ranging from 0 to 8.44. AMS and age ranked first and second in predicting the functional outcome.Conclusion: We verified the feasibility of using XGBoost to construct a nonlinear regression prediction model for the functional outcome of patients with acute SCI, and we found that age and AMS play the most important role in predicting the functional outcome.Trial registration: ClinicalTrials.gov identifier: NCT03103516.


Spinal Cord ◽  
2019 ◽  
Vol 58 (5) ◽  
pp. 609-615
Author(s):  
Rodney Sturt ◽  
Bridget Hill ◽  
Anne Holland ◽  
Peter W. New ◽  
Chloe Bevans

1999 ◽  
Vol 80 (11) ◽  
pp. 1402-1410 ◽  
Author(s):  
William O. McKinley ◽  
Amie B. Jackson ◽  
Diana D. Cardenas ◽  
Michael J. De Vivo

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