Natural History, Predictors of Outcome, and Effects of Treatment in Thoracic Spinal Cord Injury: A Multi-Center Cohort Study from the North American Clinical Trials Network

2018 ◽  
Vol 35 (21) ◽  
pp. 2554-2560 ◽  
Author(s):  
Jefferson R. Wilson ◽  
Blessing N.R. Jaja ◽  
Brian K. Kwon ◽  
James D. Guest ◽  
James S. Harrop ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Clinical Trials ◽  
Cohort Study ◽  
Natural History ◽  
Predictors Of Outcome ◽  
Thoracic Spinal Cord ◽  
The North ◽  
Thoracic Spinal ◽  
Cord Injury

scholarly journals Sonic Hedgehog modulates the inflammatory response and improves functional recovery after spinal cord injury in a thoracic contusion–compression model

2021 ◽  
Author(s):  
Hao Zhang ◽  
Alexander Younsi ◽  
Guoli Zheng ◽  
Mohamed Tail ◽  
Anna-Kathrin Harms ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Sonic Hedgehog ◽  
Functional Recovery ◽  
Intrathecal Administration ◽  
Neuroprotective Effects ◽  
Thoracic Spinal Cord ◽  
Shh Pathway ◽  
Thoracic Spinal ◽  
Cord Injury

Abstract Purpose The Sonic Hedgehog (Shh) pathway has been associated with a protective role after injury to the central nervous system (CNS). We, therefore, investigated the effects of intrathecal Shh-administration in the subacute phase after thoracic spinal cord injury (SCI) on secondary injury processes in rats. Methods Twenty-one Wistar rats were subjected to thoracic clip-contusion/compression SCI at T9. Animals were randomized into three treatment groups (Shh, Vehicle, Sham). Seven days after SCI, osmotic pumps were implanted for seven-day continuous intrathecal administration of Shh. Basso, Beattie and Bresnahan (BBB) score, Gridwalk test and bodyweight were weekly assessed. Animals were sacrificed six weeks after SCI and immunohistological analyses were conducted. The results were compared between groups and statistical analysis was performed (p < 0.05 was considered significant). Results The intrathecal administration of Shh led to significantly increased polarization of macrophages toward the anti-inflammatory M2-phenotype, significantly decreased T-lymphocytic invasion and significantly reduced resident microglia six weeks after the injury. Reactive astrogliosis was also significantly reduced while changes in size of the posttraumatic cyst as well as the overall macrophagic infiltration, although reduced, remained insignificant. Finally, with the administration of Shh, gain of bodyweight (216.6 ± 3.65 g vs. 230.4 ± 5.477 g; p = 0.0111) and BBB score (8.2 ± 0.2 vs. 5.9 ± 0.7 points; p = 0.0365) were significantly improved compared to untreated animals six weeks after SCI as well. Conclusion Intrathecal Shh-administration showed neuroprotective effects with attenuated neuroinflammation, reduced astrogliosis and improved functional recovery six weeks after severe contusion/compression SCI.

Thoracic spinal cord injury without major bone injury associated with ossification of the ligamentum flavum

2019 ◽  
Vol 24 (1) ◽  
pp. 174-177 ◽  
Author(s):  
Masaaki Machino ◽  
Shiro Imagama ◽  
Keigo Ito ◽  
Kei Ando ◽  
Kazuyoshi Kobayashi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Ligamentum Flavum ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Bone Injury ◽  
Cord Injury

Hyperbaric Oxygen Therapy After Acute Thoracic Spinal Cord Injury

Spine ◽  
2018 ◽  
Vol 43 (8) ◽  
pp. E442-E447 ◽  
Author(s):  
Asdrubal Falavigna ◽  
Manuela Peletti Figueiró ◽  
Pedro Guarise da Silva ◽  
Lucas Piccoli Conzatti ◽  
Elisa Braun Rizkalla ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Cord Injury

scholarly journals Bone Marrow-Derived Monocytes Drive the Inflammatory Microenvironment in Local and Remote Regions after Thoracic Spinal Cord Injury

2019 ◽  
Vol 36 (6) ◽  
pp. 937-949 ◽  
Author(s):  
Diana M. Norden ◽  
Timothy D. Faw ◽  
Daniel B. McKim ◽  
Rochelle J. Deibert ◽  
Lesley C. Fisher ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Thoracic Spinal Cord ◽  
Inflammatory Microenvironment ◽  
Thoracic Spinal ◽  
Cord Injury

A Developmental Rehabilitation Robotic System for a Rat With Complete Thoracic Spinal Cord Injury in Quadruped Posture

2018 ◽  
Vol 3 (3) ◽  
pp. 2109-2115 ◽  
Author(s):  
Dollaporn Anopas ◽  
Sing Yian Chew ◽  
Junquan Lin ◽  
Seng Kwee Wee ◽  
Tow Peh Er ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Robotic System ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Cord Injury ◽  
Rehabilitation Robotic

scholarly journals Horizontal ladder task-specific re-training in adult rats with contusive thoracic spinal cord injury

2011 ◽  
Vol 29 (4) ◽  
pp. 275-286
Author(s):  
Stephen M. Onifer ◽  
Oliver Zhang ◽  
Laura K. Whitnel-Smith ◽  
Kashif Raza ◽  
Christopher R. O'Dell ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Adult Rats ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Cord Injury
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