Heterotopic Autologous Chondrocyte Transplantation—A Realistic Approach to Support Articular Cartilage Repair?

2010 ◽  
Vol 16 (6) ◽  
pp. 603-616 ◽  
Author(s):  
Karym El Sayed ◽  
Andreas Haisch ◽  
Thilo John ◽  
Ulrike Marzahn ◽  
Anke Lohan ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Cartilage Repair ◽  
Autologous Chondrocyte Transplantation ◽  
Chondrocyte Transplantation ◽  
Articular Cartilage Repair ◽  
Realistic Approach ◽  
Autologous Chondrocyte

Functional Outcome of Knee Articular Cartilage Repair in Adolescent Athletes

2005 ◽  
Vol 33 (8) ◽  
pp. 1147-1153 ◽  
Author(s):  
Kai Mithöfer ◽  
Tom Minas ◽  
Lars Peterson ◽  
Howard Yeon ◽  
Lyle J. Micheli
Keyword(s):  
Articular Cartilage ◽  
Functional Outcome ◽  
Cartilage Repair ◽  
Autologous Chondrocyte Transplantation ◽  
Full Thickness ◽  
Chondrocyte Transplantation ◽  
Adolescent Athletes ◽  
Cartilage Lesions ◽  
Articular Cartilage Lesions ◽  
Autologous Chondrocyte

Background Limited information exists about the treatment of full-thickness articular cartilage lesions of the knee in adolescent athletes. Purpose To evaluate the functional outcome and athletic activity after articular cartilage repair in the knees of adolescent athletes. Study Design Case series; Level of evidence, 4. Methods Twenty adolescent athletes with full-thickness articular cartilage lesions of the knee were treated with autologous chondrocyte transplantation. Functional outcome was evaluated by subjective patient outcome rating, knee activity scores, and level of athletic participation. Results At a mean of 47 months after autologous chondrocyte transplantation, 96% of adolescents reported good or excellent results with significant increases in postoperative Tegner activity scores and Lysholm scores. Ninety-six percent returned to high-impact sports and 60% to an athletic level equal or higher than that before knee injury. Return to preinjury sports correlated with shorter preoperative symptoms and a lower number of prior operations. All adolescents with preoperative symptoms ≤12 months returned to preinjury-level athletics, compared to 33% with preoperative intervals longer than 12 months. Conclusion Treatment of full-thickness articular injuries of the knee in adolescent athletes with autologous chondrocyte transplantation yields a high rate of functional success at a mean follow-up of 47 months. The rate of return to demanding athletic activities is higher in cases in which the preoperative duration of symptoms is 12 months or less.

Articular Cartilage Repair in Soccer Players with Autologous Chondrocyte Transplantation

2005 ◽  
Vol 33 (11) ◽  
pp. 1639-1646 ◽  
Author(s):  
Kai Mithöfer ◽  
Lars Peterson ◽  
Bert R. Mandelbaum ◽  
Tom Minas
Keyword(s):  
Articular Cartilage ◽  
Cartilage Repair ◽  
Rating Scale ◽  
Skill Level ◽  
Soccer Players ◽  
Autologous Chondrocyte Transplantation ◽  
Chondrocyte Transplantation ◽  
Activity Rating ◽  
Articular Cartilage Lesions ◽  
Autologous Chondrocyte

Background The ability of autologous chondrocyte transplantation to produce and maintain an effective articular cartilage repair under high mechanical demands has not been investigated. Hypothesis Autologous chondrocyte transplantation provides a reliable and durable repair of full-thickness knee articular cartilage lesions in high-demand athletes. Study Design Case series; Level of evidence, 4. Methods A total of 45 soccer players were evaluated 41 ± 4 months after autologous chondrocyte transplantation for their ability to return to soccer, the timing of their return, skill level, and functional outcome rating by the Tegner activity rating scale score and Brittberg score. The factors influencing the return to sport were analyzed. Results Of these players, 72% reported good to excellent results, with significant overall improvement of Tegner activity rating scale scores; 33% returned to soccer, including 83% of competitive-level players and 16% of recreational players. Of the returning players, 80% returned to the same skill level and 87% maintained their ability to play soccer at 52 ± 8 months postoperatively. Players who successfully returned to soccer were significantly younger and had a shorter preoperative duration of symptoms than did patients who did not return to the sport. Concomitant adjuvant procedures did not adversely affect the ability to return to soccer. Conclusion Repair of knee articular cartilage lesions by autologous chondrocyte transplantation in high-performance athletes is particularly successful in younger, competitive athletes with limited preoperative intervals.

scholarly journals Autologous chondrocyte transplantation: a phase 1 study protocol to validate the safety and feasibility of a new advanced cell therapy product for articular cartilage repair in Brazil

2020 ◽  
Vol 7 (2) ◽  
pp. 123
Author(s):  
Alessandro Rozim Zorzi ◽  
Eliane Antonioli ◽  
Moises Cohen ◽  
Camila Cohen Kaleka ◽  
Andrea Tiemi Kondo ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Magnetic Resonance ◽  
Conservative Treatment ◽  
Cell Therapy ◽  
Cartilage Repair ◽  
Phase 1 ◽  
Autologous Chondrocyte Transplantation ◽  
Chondrocyte Transplantation ◽  
Phase 1 Study ◽  
Autologous Chondrocyte

<p class="abstract"><strong>Background:</strong> Membrane-assisted autologous chondrocyte transplantation is considered the gold standard surgical technique to treat greater than two millimetres diameter cartilage lesions in the knee in patients after conservative treatment failure. However, this technique is only available in developed countries of North America, Europe and Japan. According to Brazilian law, it is considered an advanced cell therapy product. There is currently no product of this type enabled for clinical use in Brazil. Following the request of the Brazilian regulatory agency (ANVISA), this phase 1 study was developed. The objective is to access feasibility and safety of a new membrane-assisted autologous chondrocyte product.</p><p class="abstract"><strong>Methods:</strong> Three participants with a larger than two millimetres articular cartilage lesion in the distal femur or the patella, which did not improve their symptoms with conservative treatment, will be submitted to an arthroscopically assisted cartilage biopsy. After isolation and expansion in a good manufacturing practices facility, chondrocyte seeded collagen membranes will be surgically inserted in the lesion and fixed with fibrin glue. The follow-up period will last 1 year. Primary outcome will be incidence and severity of complications according to NCI-CTCAE version 4.0. Secondary outcomes will be Western-Ontario McMaster Universities Osteoarthritis Index scale, International Knee Documentation Committee subjective scale and magnetic resonance observation of cartilage repair tissue magnetic resonance scale.</p><p class="abstract"><strong>Conclusions: </strong>This study, together with previous preclinical results and international experience, will allow patients in Latin America to have access to this advanced cell therapy.</p><p class="abstract"><strong>Trial Registration:</strong> Brazilian registry of clinical trials RBR-6fgy76 (http://www.ensaiosclinicos.gov.br/rg/RBR-6fgy76/). Ethical approval: CAAE: 73911617.2.0000.0071.</p>

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