Familial Adenomatous Polyposis–Associated, Cribriform Morular Variant of Papillary Thyroid Carcinoma Harboring a K-RAS Mutation: Case Presentation and Review of Molecular Mechanisms

Thyroid ◽  
2014 ◽  
Vol 24 (7) ◽  
pp. 1184-1189 ◽  
Author(s):  
Silvana M. Giannelli ◽  
Laron McPhaul ◽  
Jon Nakamoto ◽  
Andrew G. Gianoukakis
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Familial Adenomatous Polyposis ◽  
Thyroid Carcinoma ◽  
Molecular Mechanisms ◽  
Adenomatous Polyposis ◽  
Papillary Thyroid ◽  
Ras Mutation ◽  
Case Presentation ◽  
Cribriform Morular Variant

scholarly journals Familial Adenomatous Polyposis—Rendering a Diagnosis Based on Recognition of an Unusual Primary Thyroid Neoplasm

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
David F. Schaeffer ◽  
Eric M. Yoshida ◽  
David A. Owen ◽  
Kenneth W. Berean
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Familial Adenomatous Polyposis ◽  
Thyroid Carcinoma ◽  
Clinical Features ◽  
Germline Mutations ◽  
Initial Diagnosis ◽  
Thyroid Neoplasm ◽  
Adenomatous Polyposis ◽  
Papillary Thyroid ◽  
Cribriform Morular Variant

It has been well established in the literature that the cribriform-morular variant of papillary thyroid carcinoma (CMVPTC) has been observed with higher frequency in familial adenomatous polyposis (FAP) patients. In the usual setting, patients with FAP are identified based on their germline mutations and the diagnosis of thyroid neoplasm is made after the FAP diagnosis. We herein report a case in which the recognition of a CMVPTC led to the initial diagnosis of FAP. The histological and clinical features of CMVPTC are reviewed with emphasis on its relationship to FAP.

Cribriform-morular variant of papillary thyroid carcinoma as initial presentation of the familial adenomatous polyposis

2015 ◽  
Vol 144 (6) ◽  
pp. 279-280
Author(s):  
Beatriz Febrero ◽  
José Manuel Rodríguez ◽  
Antonio Ríos ◽  
Pascual Parrilla
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Familial Adenomatous Polyposis ◽  
Thyroid Carcinoma ◽  
Initial Presentation ◽  
Adenomatous Polyposis ◽  
Papillary Thyroid ◽  
Cribriform Morular Variant

Multifocality in a Patient with Cribriform–Morular Variant of Papillary Thyroid Carcinoma Is an Important Clue for the Diagnosis of Familial Adenomatous Polyposis

Thyroid ◽  
2019 ◽  
Vol 29 (11) ◽  
pp. 1606-1614 ◽  
Author(s):  
Jun Park ◽  
Jong-Won Kim ◽  
Hyunju Park ◽  
So Young Park ◽  
Tae Hyuk Kim ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Familial Adenomatous Polyposis ◽  
Thyroid Carcinoma ◽  
Adenomatous Polyposis ◽  
Papillary Thyroid ◽  
Important Clue ◽  
Cribriform Morular Variant

Cribriform-Morular Variant of Papillary Thyroid Carcinoma With Poorly Differentiated Features: A Case Report With Immunohistochemical and Molecular Genetic Analysis

2018 ◽  
Vol 27 (3) ◽  
pp. 294-304 ◽  
Author(s):  
Jessica Corean ◽  
Larissa V. Furtado ◽  
Sabah Kadri ◽  
Jeremy P. Segal ◽  
Lyska L. Emerson
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Familial Adenomatous Polyposis ◽  
Thyroid Carcinoma ◽  
Differentiated Thyroid Carcinoma ◽  
Apc Gene ◽  
Adenomatous Polyposis ◽  
Papillary Thyroid ◽  
Poorly Differentiated Thyroid Carcinoma ◽  
Poorly Differentiated ◽  
Cribriform Morular Variant

Cribriform-morular variant of papillary thyroid carcinoma (CMVPTC) is usually an inherited malignancy and may be a presenting indicator of familial adenomatous polyposis syndrome although it may occasionally be sporadic. Known CMVPTC mutations include adenomatous polyposis coli ( APC) and β-catenin ( CTNNB1) genes. Despite its malignant classification, CMVPTC is considered to be a well-differentiated thyroid tumor with a generally good behavior. In contrast, poorly differentiated thyroid carcinoma is an aggressive tumor. We report a case of CMVPTC with poorly differentiated features in a young female without phenotypic features of familial adenomatous polyposis but with known germline alterations of the APC gene. High throughput sequencing showed germline chromosome 5q deletion encompassing the APC gene in all components with additional unique genetic alterations in the somatic components. A single nucleotide substitution (c.1548+1G>A, NM_000038.5) located one base pair downstream of exon 12 of the APC gene was identified in the CMVPTC component, and a pathogenic frameshift deletion in exon 14 of APC (c.3642del, p.Ser1214Argfs*51, NM_000038.5) was identified in the poorly differentiated thyroid carcinoma component. No other cancer-associated genes were identified by our techniques. Our case represents a rare phenomenon of poorly differentiated features in association with CMVPTC. To our knowledge, ours is the only such report of poorly differentiated features arising in association with an inherited CMVPTC.

Cribriform-morular variant of Papillary Thyroid Carcinoma: Clue to Early Detection of Familial Adenomatous Polyposis-associated Colon Cancer

2004 ◽  
Vol 28 (9) ◽  
pp. 886-889 ◽  
Author(s):  
Chisato Tomoda ◽  
Akira Miyauchi ◽  
Takashi Uruno ◽  
Yuuki Takamura ◽  
Yasuhiro Ito ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Papillary Thyroid Carcinoma ◽  
Familial Adenomatous Polyposis ◽  
Early Detection ◽  
Thyroid Carcinoma ◽  
Adenomatous Polyposis ◽  
Papillary Thyroid ◽  
Cribriform Morular Variant

scholarly journals Cribriform-morular variant of papillary thyroid carcinoma and its association with familial adenomatous polyposis

2019 ◽  
Vol 32 (3) ◽  
pp. 399-401 ◽  
Author(s):  
Alejandro Perez ◽  
Sarah Findeis ◽  
Atin Agarwal ◽  
Julia Berry ◽  
Katie King
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Familial Adenomatous Polyposis ◽  
Thyroid Carcinoma ◽  
Adenomatous Polyposis ◽  
Papillary Thyroid ◽  
Cribriform Morular Variant

Cribriform-morular variant of papillary thyroid carcinoma: Characteristic histologic feature of adenomatous polyposis. A case report

2012 ◽  
Vol 73 (3) ◽  
pp. 213-215 ◽  
Author(s):  
Caroline Gronnier ◽  
Gianluca Donatini ◽  
Emmanuelle Leteurtre ◽  
Christine Do Cao ◽  
Bruno Carnaille
Keyword(s):  
Case Report ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Adenomatous Polyposis ◽  
Papillary Thyroid ◽  
Histologic Feature ◽  
Cribriform Morular Variant

Papillary thyroid carcinoma and familial adenomatous polyposis of the colon

2009 ◽  
Vol 30 (1) ◽  
pp. 58-60 ◽  
Author(s):  
Kimberly A. Donnellan ◽  
Steven A. Bigler ◽  
Richard O. Wein
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Familial Adenomatous Polyposis ◽  
Thyroid Carcinoma ◽  
Adenomatous Polyposis ◽  
Papillary Thyroid
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