Effective Induction of Type 1 Helper IgG2aand Cytotoxic T-Cell Responses in Mice Following Immunization with Human Papillomavirus Type 16 E2 in MF59

2008 ◽  
Vol 21 (2) ◽  
pp. 225-234 ◽  
Author(s):  
Lucy Heinemann ◽  
Lauren Woodfield ◽  
Mira Amer ◽  
Merilyn Hibma
2012 ◽  
Vol 23 (12) ◽  
pp. 1301-1312 ◽  
Author(s):  
Koen Oosterhuis ◽  
Esil Aleyd ◽  
Kim Vrijland ◽  
Ton N. Schumacher ◽  
John B. Haanen

Author(s):  
Elena Sadovnikova ◽  
Xiaojiu Zhu ◽  
Shona M. Collins ◽  
Peter Beverley ◽  
Hans J. Stauss

1991 ◽  
Vol 119 (2) ◽  
pp. 230-236 ◽  
Author(s):  
Katherine Luzuriaga ◽  
Richard A. Koup ◽  
Cheryl A. Pikora ◽  
Doreen B. Brettler ◽  
John L. Sullivan

Vaccines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 134
Author(s):  
Zekun Mu ◽  
Barton F. Haynes ◽  
Derek W. Cain

The SARS-CoV-2 pandemic introduced the world to a new type of vaccine based on mRNA encapsulated in lipid nanoparticles (LNPs). Instead of delivering antigenic proteins directly, an mRNA-based vaccine relies on the host’s cells to manufacture protein immunogens which, in turn, are targets for antibody and cytotoxic T cell responses. mRNA-based vaccines have been the subject of research for over three decades as a platform to protect against or treat a variety of cancers, amyloidosis and infectious diseases. In this review, we discuss mRNA-based approaches for the generation of prophylactic and therapeutic vaccines to HIV. We examine the special immunological hurdles for a vaccine to elicit broadly neutralizing antibodies and effective T cell responses to HIV. Lastly, we outline an mRNA-based HIV vaccination strategy based on the immunobiology of broadly neutralizing antibody development.


2005 ◽  
Vol 18 (4) ◽  
pp. 234-242 ◽  
Author(s):  
Silvia Garbelli ◽  
Stefania Mantovani ◽  
Belinda Palermo ◽  
Claudia Giachino

2004 ◽  
Vol 169 (12) ◽  
pp. 1322-1330 ◽  
Author(s):  
Frédéric Ebstein ◽  
Carole Sapede ◽  
Pierre-Joseph Royer ◽  
Marie Marcq ◽  
Catherine Ligeza-Poisson ◽  
...  

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