This chapter discusses the complete quadrilateral line arrangement, and especially its relationship with the space of regular points of the system of partial differential equations defining the Appell hypergeometric function. Appell introduced four series F1, F2, F3, F4 in two complex variables, each of which generalizes the classical Gauss hypergeometric series and satisfies its own system of two linear second order partial differential equations. The solution spaces of the systems corresponding to the series F2, F3, F4 all have dimension 4, whereas that of the system corresponding to the series F1 has dimension 3. This chapter focuses on the F1-system whose monodromy group, under certain conditions, acts on the complex 2-ball. It first considers the action of S5 on the blown-up projective plane before turning to Appell hypergeometric functions, arithmetic monodromy groups, and an invariant known as the signature.