In this paper, inverse scattering problems for a system of differential equations of the first order are considered. The Marchenko approach is used to solve the inverse scattering problem. The system of Marchenko integral equations is reduced to a linear system of algebraic equations such that the solution of the resulting system yields to the unknown coefficients of the system of first-order differential equations. Illustrative examples are provided to demonstrate the preciseness and effectiveness of the proposed technique. The results are compared with the exact solution by using computer simulations.