Effect of parenteral nutrition on protein synthesis in adult cancer patients

1981 ◽  
Vol 34 (8) ◽  
pp. 1484-1488 ◽  
Author(s):  
T P Stein ◽  
G P Buzby ◽  
E F Rosato ◽  
J L Mullen
1991 ◽  
Vol 81 (2) ◽  
pp. 215-222 ◽  
Author(s):  
M. Salleh M. Ardawi

1. The effect of total parenteral nutrition with or without glutamine enrichment was studied in septic rats after 4 days of treatment. 2. Septic rats treated with glutamine-enriched total parenteral nutrition survived sepsis significantly better than other TPN-treated septic rats: the cumulative percentage of deaths over 4 days in septic rats treated with glutamine-enriched total parenteral nutrition was 25% compared with 55% in septic rats given total parenteral nutrition without glutamine and 70% in septic rats given glucose. 3. Glutamine-enriched total parenteral nutrition resulted in improved nitrogen balance in septic rats: the cumulative nitrogen balance over the 4 days of treatment was the least negative as compared with other groups of septic rats. 4. The rate of loss of intracellular glutamine in skeletal muscle was markedly decreased (P < 0.001) in response to glutamine-enriched total parenteral nutrition in septic rats. 5. The rate of protein synthesis was increased (21.2%) and the rate of protein degradation was decreased (35.5%) in response to glutamine-enriched total parenteral nutrition in septic rats. 6. It is concluded that the administration of glutamine-enriched total parenteral nutrition is beneficial to septic rats and possibly to septic patients.


Author(s):  
Avani Changela ◽  
Evangelia Davanos ◽  
Hemangkumar Javaiya

2012 ◽  
Vol 4 (4) ◽  
pp. 759-762 ◽  
Author(s):  
FRANCESCO IOVINO ◽  
PASQUALE PIO AURIEMMA ◽  
LUCA DEL VISCOVO ◽  
SARA SCAGLIARINI ◽  
MARILENA DI NAPOLI ◽  
...  

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