A Survey of Epstein-Barr Virus DNA in Lymphoid Tissue: Frequent Detection in Hodgkin’s Disease

1989 ◽  
Vol 91 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Stephen P. Staal ◽  
Richard Ambinder ◽  
William E. Beschorner ◽  
Gary S. Hayward ◽  
Risa Mann
Keyword(s):  
Hodgkin's Disease ◽  
Lymphoid Tissue ◽  
Epstein Barr Virus ◽  
Hodgkin’S Disease ◽  
Barr Virus ◽  
Epstein Barr

Influence of Epstein–Barr Virus Genomes on Patient Survival in Hodgkin’s Disease

1992 ◽  
Vol 98 (3) ◽  
pp. 319-323 ◽  
Author(s):  
Christian Fellbaum ◽  
Martin-Leo Hansmann ◽  
Hans Niedermeyer ◽  
Irmgard Kraus ◽  
Martti J. Alavaikko ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Epstein Barr Virus ◽  
Patient Survival ◽  
Hodgkin’S Disease ◽  
Barr Virus ◽  
Epstein Barr ◽  
Virus Genomes

Comparison of Epstein-Barr Virus Markers in Reed-Sternberg Cells in Adult Hodgkin's Disease Tissues from an Industrialized and a Developing Country

1995 ◽  
Vol 17 (1-2) ◽  
pp. 163-168 ◽  
Author(s):  
Mohammed I. Belkaid ◽  
Josette Briegre ◽  
Zahia Djebbara ◽  
Kheira Beldjord ◽  
Jean Marie Andrieu ◽  
...  
Keyword(s):  
Developing Country ◽  
Hodgkin's Disease ◽  
Epstein Barr Virus ◽  
Hodgkin’S Disease ◽  
Barr Virus ◽  
Epstein Barr

HIGH FREQUENCY OF EPSTEIN-BARR VIRUS GENOME IN HIV-POSITIVE PATIENTS WITH HODGKIN'S DISEASE

The Lancet ◽  
1989 ◽  
Vol 333 (8652) ◽  
pp. 1458 ◽  
Author(s):  
Stefania Uccini ◽  
Francesca Monardo ◽  
LuigiP. Ruco ◽  
CarloD. Baroni ◽  
Alberto Faggioni ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
High Frequency ◽  
Epstein Barr Virus ◽  
Hodgkin’S Disease ◽  
Virus Genome ◽  
Hiv Positive ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Epstein–Barr virus gene polymorphisms in Chinese Hodgkin’s disease cases and healthy donors: identification of three distinct virus variants

2001 ◽  
Vol 82 (5) ◽  
pp. 1157-1167 ◽  
Author(s):  
X.-G. Zhou ◽  
K. Sandvej ◽  
P.-J. Li ◽  
X.-L. Ji ◽  
Q.-H. Yan ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Epstein Barr Virus ◽  
Hodgkin’S Disease ◽  
Epidemiological Studies ◽  
Latent Membrane Protein 1 ◽  
Barr Virus ◽  
Healthy Donors ◽  
Healthy Chinese ◽  
Epstein Barr ◽  
Virus Isolates

Epstein–Barr virus (EBV) is associated with several malignancies. Specific EBV gene variants, e.g. the BamHI f configuration, a C-terminal region 30 bp deletion in the latent membrane protein-1 (LMP1) gene (del-LMP) and the loss of an XhoI site in LMP1 (XhoI-loss), are found in Chinese cases of nasopharyngeal carcinoma (NPC), suggesting that EBV sequence variation may be involved in oncogenesis. In order to understand better the epidemiology of these EBV variants, they were studied in virus isolates from EBV-positive Chinese cases of Hodgkin’s disease (HD; n=71) and donor throat washings from healthy Chinese. Sequencing was performed of 15 representative EBV isolates, including the first analysis of the LMP1 promoter in Asian wild-type EBV isolates. The following observations were made. (i) Three EBV LMP1 variants were identified, designated Chinese groups (CG) 1–3. In both EBV-associated HD and in healthy Chinese, CG1-like viruses showing del-LMP1 and XhoI-loss were predominant. (ii) CG1viruses were distinct from European and African variants, suggesting that this profile is useful for epidemiological studies. (iii) Specific patterns of mutations were present in the LMP1 promoter in both CG1 and CG2. (iv) The BamHI f variant was not found in Chinese HD, in contrast to Chinese NPC and European HD. This study confirms that EBV isolates in Chinese HD and other tumours differ from those reported in Western cases. However, this reflects the predominant virus strain present in the healthy Chinese population, suggesting that these are geographically restricted polymorphisms rather than tumour-specific strains.

Evaluation of epstein-barr virus antibody patterns and detection of viral markers in the biopsies of patients with Hodgkin's disease

1994 ◽  
Vol 59 (1) ◽  
pp. 48-50 ◽  
Author(s):  
Paul H. Levine ◽  
Gorm Pallesen ◽  
Peter Ebbesen ◽  
Nancy Harris ◽  
Alfred S. Evans ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Epstein Barr Virus ◽  
Hodgkin’S Disease ◽  
Virus Antibody ◽  
Barr Virus ◽  
Epstein Barr
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