scholarly journals Tryptophan in Alcoholism Treatment II:  Inhibition of the Rat Liver Mitochondrial Low Km Aldehyde Dehydrogenase Activity, Elevation of Blood Acetaldehyde Concentration and Induction of Aversion to Alcohol by Combined Administration of Tryptophan and Benserazide

2011 ◽  
Vol 46 (6) ◽  
pp. 661-671 ◽  
Author(s):  
Abdulla A.-B. Badawy ◽  
Samina Bano ◽  
Alex Steptoe
Keyword(s):  
Dehydrogenase Activity ◽  
Rat Liver ◽  
Aldehyde Dehydrogenase ◽  
Alcoholism Treatment ◽  
Acetaldehyde Concentration ◽  
Combined Administration ◽  
Aldehyde Dehydrogenase Activity

Decrease in calcium carbimide (calcium cyanamide)-induced inhibition of rat hepatic aldehyde dehydrogenases by multiple ethanol administration

1984 ◽  
Vol 62 (5) ◽  
pp. 544-550 ◽  
Author(s):  
C. W. Loomis ◽  
J. F. Brien
Keyword(s):  
Dehydrogenase Activity ◽  
Aldehyde Dehydrogenase ◽  
Enzyme Inhibitor ◽  
Liver Homogenate ◽  
Male Rats ◽  
Ethanol Administration ◽  
Ethanol Dose ◽  
Acetaldehyde Concentration ◽  
High K ◽  
Aldehyde Dehydrogenase Activity

Ethanol (0.3 g/kg) was administered intravenously to adult, male rats at 3 h or at 1 and 3 h after gastric intubation of 7 mg/kg calcium carbimide (CC). For animals administered CC and two ethanol doses, blood ethanol concentration was similar for the two doses; however, blood acetaldehyde concentration was significantly less for the second ethanol dose compared with the first dose as determined by the area-under-curve data. Hepatic aldehyde dehydrogenase activity was determined over the 3.5-to 5-h interval after CC pretreatment. The inhibition of low Km and high Km aldehyde dehydrogenase activity in liver homogenate and in hepatic mitochondrial, cytosolic, and microsomal fractions was significantly less for rats administered CC followed by two ethanol doses compared with that for animals administered CC alone or CC followed by one ethanol dose. The data demonstrate that increased acetaldehyde concentration, produced during the CC – ethanol interaction, can augment the recovery of hepatic aldehyde dehydrogenase activity following CC pretreatment and indicate the existence of a displaceable enzyme inhibitor derived from CC.

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