scholarly journals Novel pyrazolopyrimidine derivatives inhibit angiogenesis and tumor growth in a mouse Lewis lung carcinoma model

2015 ◽  
Vol 26 ◽  
pp. ii36 ◽  
Author(s):  
M. Michailidou ◽  
V. Giannouli ◽  
I. Kostakis ◽  
V. Kotsikoris ◽  
P. Marakos ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Lewis Lung ◽  
Lewis Lung Carcinoma Model

scholarly journals new bIologIcal model of moderate InhIbItIon of tumor and metastases growth wIth prolonged leukopenIa In mIce

2016 ◽  
Vol 1 (5) ◽  
pp. 121-125
Author(s):  
Зуева ◽  
Elena Zueva ◽  
Разина ◽  
Tatyana Razina ◽  
Ермакова ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Tumor Therapy ◽  
Biological Model ◽  
Tumor Growth Inhibition ◽  
Lewis Lung ◽  
Inhibition Of Tumor Growth ◽  
Toxic Manifestation ◽  
Cyclophosphamide Dose

A new biological model of moderate inhibition of tumor growth and metastases with prolonged leukopenia on C57Bl/6 mice with the Lewis Lung Carcinoma was designed. The model was created by the injection of cyclophosphamide (dose 83.3mg/kg) on 6th, 12th, 18th days after tumor cells transplantation on animals. Experiment showed that 3-fold cyclo-phosphamide use leads to growth of primary tumor and metastases inhibition. Tumor growth inhibition was 34% on 21st day after cyclophosphamide inject. The number of metastases decreased by 4.7times (p<0,01). Metastatic area reduced. Metastasis frequency made 100%. In addition, the course of cyclophosphamide application caused inhibition of granulocytic and lymphoid hematopoiesis. The reducing the number of segmented neutrophils and lymphocytes was showed on the 3rd day after 1, 2 and 3 injections of cyclophosphamide. The model can be used to study the efficacy of drugs in tumor therapy and in correction of such toxic manifestation of chemotherapy as leukopenia.

scholarly journals ATIQCTPC targeting MMP-9: a key step to slowing primary tumor growth and inhibiting metastasis of lewis lung carcinoma in vivo

Oncotarget ◽  
2017 ◽  
Vol 8 (38) ◽  
pp. 63881-63889 ◽  
Author(s):  
Yuji Wang ◽  
Xinyi Xu ◽  
Ce Song ◽  
Jianhui Wu ◽  
Xi Hu ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Lung Carcinoma ◽  
Primary Tumor ◽  
Lewis Lung Carcinoma ◽  
Lewis Lung ◽  
Primary Tumor Growth

Hybrid-primed lymphocytes and hybrid vaccination prevent tumor growth of lewis lung carcinoma in mice

Pneumologie ◽  
2006 ◽  
Vol 60 (S 1) ◽  
Author(s):  
S Rajkumar ◽  
R Schermuly ◽  
M Schneider ◽  
S Pullamsetti ◽  
F Grimminger ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Lewis Lung ◽  
Prevent Tumor Growth

Effects of stress on tumor growth and metastasis in mice bearing lewis lung carcinoma

1989 ◽  
Vol 25 (11) ◽  
pp. 1583-1588 ◽  
Author(s):  
T. Giraldi ◽  
L. Perissin ◽  
S. Zorzet ◽  
P. Piccini ◽  
V. Rapozzi
Keyword(s):  
Tumor Growth ◽  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Lewis Lung ◽  
Effects Of Stress ◽  
Tumor Growth And Metastasis

Abstract C78: The mu opioid receptor regulates Lewis lung carcinoma tumor growth and metastasis

2009 ◽  
Author(s):  
Biji Mathew ◽  
Frances E. Lennon ◽  
Jessica Siegler ◽  
Lynnette Gerhold ◽  
Nurbek Mambetsariev ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Opioid Receptor ◽  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Mu Opioid Receptor ◽  
Lewis Lung ◽  
Mu Opioid ◽  
Tumor Growth And Metastasis ◽  
Carcinoma Tumor
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