Cytokine genetic variations and worse quality of life among family caregivers of head and neck cancer patients in palliative care

Abstract Background Early palliative care (EPC) is an important aspect of cancer management but has never been evaluated in patients with head and neck cancer. Hence, we performed this study to determine whether the addition of EPC to standard therapy leads to an improvement in the quality of life (QOL), decrease in symptom burden and improvement in overall survival. Methods Adult patients with squamous cell carcinoma of the head and neck region planned for palliative systemic therapy, were allocated 1:1 to either standard systemic therapy without (STD arm) or with comprehensive EPC service referral (EPC arm). Patients were administered the revised Edmonton Symptom Assessment Scale (ESAS-r) and the Functional Assessment of Cancer Therapy for head and neck cancer (FACIT HN) questionnaire at baseline and every 1 month thereafter for 3 months. The primary endpoint was a change in the QOL measured at 3 months after random assignment. All statistical tests were 2-sided. Results Ninety patients were randomly assigned to each arm. There was no statistical difference in the change in the FACT-H&N total score (P = .94), FACT-H&N Trial Outcome Index (P = .95), FACT- G (general) total (P = .84) and ESAS-r scores at 3 months between the two arms. The median overall survival was similar between the two arms (Hazard ratio for death = 1.01, 95% CI = 0.74–1.35). There were 5 in-hospital deaths in both arms (5.6% for both, P = .99). Conclusions In this phase III study, the integration of EPC in head and neck cancer patients did not lead to an improvement in the QOL or survival.

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Patient-reported toxicity and quality of life profiles in head and neck cancer patients treated with definitive radiotherapy or chemoradiation

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2021.05.114 ◽

2021 ◽

Author(s):

Lisa Vanden Bosch ◽

Hans Paul van der Laan ◽

Arjen van der Schaaf ◽

Sjoukje F. Oosting ◽

Gyorgy B. Halmos ◽

...

Keyword(s):

Quality Of Life ◽

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

Definitive Radiotherapy ◽

Patient Reported

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P174 A RANDOMISED STUDY OF NUTRITIONAL SUPPORT AND QUALITY OF LIFE IN HEAD AND NECK CANCER PATIENTS

Clinical Nutrition Supplements ◽

10.1016/s1744-1161(08)70236-9 ◽

2008 ◽

Vol 3 ◽

pp. 102-103

Author(s):

E.M. Silander ◽

E.B. Hammerlid

Keyword(s):

Quality Of Life ◽

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

Nutritional Support ◽

Randomised Study

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Xerostomia Quality of Life Scale (XeQoLS) questionnaire: validation of Italian version in head and neck cancer patients

La radiologia medica ◽

10.1007/s11547-017-0798-7 ◽

2017 ◽

Vol 123 (1) ◽

pp. 44-47 ◽

Cited By ~ 1

Author(s):

Luciana Lastrucci ◽

Silvia Bertocci ◽

Vittorio Bini ◽

Simona Borghesi ◽

Roberta De Majo ◽

...

Keyword(s):

Quality Of Life ◽

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

Questionnaire Validation ◽

Italian Version ◽

Quality Of Life Scale ◽

Life Scale

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Filipino head and neck cancer patients and their quality of life

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20200540 ◽

2020 ◽

Vol 6 (3) ◽

pp. 439

Author(s):

Frederic Ivan L. Ting ◽

Aylmer Rex B. Hernandez ◽

Reno Eufemon P. Cereno ◽

Irisyl B. Orolfo-Real ◽

Corazon A. Ngelangel

Keyword(s):

Quality Of Life ◽

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

The Philippines ◽

Head And Neck Cancers ◽

The Social ◽

The University

Background: In the management of head and neck cancer (HNC), assessment of quality of life (QoL) is imperative because of the potentially debilitating effect of treatment toxicities. Currently, there are no published data assessing the QoL in Filipino HNC patients, thus this study.Methods: This cross-sectional study utilized the University of the Philippines - Department of Health Quality of Life scale. Patients with head and neck cancers at the University of the Philippines - Philippine General Hospital from February to September 2019 were invited to participate. Results: A total of 418 patients were included in the study with a mean age of 42 years old (range 18 to 73 years old). In general, Filipino head and neck cancer patients had moderate QoL (mean score of 4.59±0.79). All of the QoL domains (physical, emotional, cognitive, and related functions) had a score of 3-5 (moderate), except for the social status domain which had a mean score of 5.51±0.83 (high). Among socio-demographic factors, patients who are employed and with additional funding sources on top of their income have better global QoL (p<0.01). Clinically, patients with higher stages of disease, fungating tumors, post-laryngectomy, have a feeding tube, with a tracheostomy, and had chemotherapy have lower global QoL (p<0.01).Conclusions: Filipino patients with head and neck cancers have an overall moderate quality of life, with high scores in the social domain. Patients with higher tumor burdens and have been exposed to chemotherapy have lower QoL scores, while patients with financial stability and aid have better QoL scores.

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