scholarly journals B-20The Effect of Music Therapy on the Mirror Neuron System in Children with Autism Spectrum Disorder: A Systematic Literature Review

2017 ◽  
Vol 32 (6) ◽  
pp. 667-765
Author(s):  
T Perez ◽  
I Barnes ◽  
M Sosa ◽  
M Rodriguez ◽  
I Tourgeman
Author(s):  
Martin Brüne

Autism spectrum disorder (ASD) is characterized by social communication deficits, impaired social interaction, and restricted and stereotyped behaviours and interests. The typical onset is during early childhood. Behaviourally, people with ASD have difficulties in tolerating proximity. Insecure attachment is frequently observed. At the cognitive level, people with ASD have selective difficulties in mentalizing or ‘theory of mind’, possibly related to a dysfunctional mirror neuron system and alterations of the oxytocin system. Conversely, many with ASD (particularly those formerly diagnosed with Asperger’s syndrome) have superior technical skills. It has been hypothesized that the brains of individuals with ASD are skewed to maleness, possibly linked to genomic imprinting of paternal genes. The preservation of genes that predispose to ASD may have undergone sexual selection fostering ‘slow’ life-history strategies. None of the evolutionary hypotheses on ASD is conclusive so far, but open to empirical testing.


IEEE Access ◽  
2021 ◽  
pp. 1-1
Author(s):  
Katrin D. Bartl-Pokorny ◽  
Malgorzata Pykala ◽  
Pinar Uluer ◽  
Duygun Erol Barkana ◽  
Alice Baird ◽  
...  

2015 ◽  
Vol 8 (6) ◽  
pp. 694-708 ◽  
Author(s):  
Hsiang-Yun Chien ◽  
Susan Shur-Fen Gau ◽  
Yung-Chin Hsu ◽  
Yu-Jen Chen ◽  
Yu-Chun Lo ◽  
...  

2021 ◽  
Author(s):  
Lei Xu ◽  
Xiaoxiao Zheng ◽  
Shuxia Yao ◽  
Jialin Li ◽  
Meina Fu ◽  
...  

The amygdala is a core node in the social brain which exhibits structural and functional abnormalities in Autism spectrum disorder and there is evidence that the mirror neuron system (MNS) can functionally compensate for impaired emotion processing following amygdala lesions. In the current study, we employed an fMRI paradigm in 241 subjects investigating MNS and amygdala responses to observation, imagination and imitation of dynamic facial expressions and whether these differed in individuals with higher as opposed to lower autistic traits. Results indicated that individuals with higher compared to lower autistic traits showed reduced left amygdala responses to imitation and enhanced responses in the left superior temporal sulcus (STS) of the MNS to observation, imagination and imitation. Additionally, functional connectivity between the left amygdala and the left STS as well as some other MNS regions was increased in individuals with higher autistic traits, especially during imitation of fearful expressions. The amygdala-MNS connectivity significantly moderated autistic group differences on recognition memory for fearful faces and real-life social network indices, indicating that increased amygdala-MNS connectivity could diminish the social behavioral differences between higher and lower autistic trait groups. Overall, findings demonstrate decreased imitation-related amygdala activity in individuals with higher autistic traits in the context of increased cortical MNS activity and amygdala-MNS connectivity which may functionally compensate for amygdala dysfunction and social deficits. Training targeting the MNS may capitalize on this compensatory mechanism for therapeutic benefits in Autism spectrum disorder.


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