scholarly journals NURBS: a database of experimental and predicted nuclear receptor binding sites of mouse

2012 ◽  
Vol 29 (2) ◽  
pp. 295-297 ◽  
Author(s):  
Y. Fang ◽  
H.-X. Liu ◽  
N. Zhang ◽  
G. L. Guo ◽  
Y.-J. Y. Wan ◽  
...  
Keyword(s):  
Nuclear Receptor ◽  
Receptor Binding ◽  
Binding Sites

scholarly journals DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin

Endocrinology ◽  
2017 ◽  
Vol 158 (10) ◽  
pp. 3212-3234 ◽  
Author(s):  
Laurel A Coons ◽  
Sylvia C Hewitt ◽  
Adam B Burkholder ◽  
Donald P McDonnell ◽  
Kenneth S Korach
Keyword(s):  
Dna Sequence ◽  
Nuclear Receptor ◽  
Receptor Binding ◽  
Binding Sites ◽  
Sequence Constraints

OESTROGEN AND PROGESTERONE RECEPTOR CONCENTRATIONS IN HUMAN ENDOMETRIUM DURING GESTATION

1979 ◽  
Vol 92 (3) ◽  
pp. 547-552 ◽  
Author(s):  
B. Kreitmann ◽  
F. Bayard
Keyword(s):  
Menstrual Cycle ◽  
Progesterone Receptor ◽  
Nuclear Receptor ◽  
Receptor Binding ◽  
Binding Sites ◽  
Progesterone Receptors ◽  
Oestrogen Receptors ◽  
Secretory Phase ◽  
Ovulatory Period ◽  
Late Secretory Phase

ABSTRACT The concentrations of endometrial oestrogen and progesterone receptors, both in cytosol and in nuclei, have been studied at 8–10 weeks and at 38–40 weeks of gestation. At these two periods the concentration of oestrogen receptors is comparable with the concentration observed during the late secretory phase of the menstrual cycle. At 8–10 weeks of gestation, concentration of progesterone receptors is also comparable with the concentration observed during the secretory phase of the menstrual cycle, but at term there is a significant increase (P < 0.05) and the concentration is then comparable with the concentration observed in the pre-ovulatory period of the menstrual cycle. The receptor binding sites are always predominantly found in nuclei and the increase in progesterone nuclear receptor at term suggests that in man the progesterone withdrawal is not a necessary step in the mechanism of uterine activation during parturition as it is in other species.

Evolution of the repertoire of nuclear receptor binding sites in genomes

2011 ◽  
Vol 334 (1-2) ◽  
pp. 76-82 ◽  
Author(s):  
David Cotnoir-White ◽  
David Laperrière ◽  
Sylvie Mader
Keyword(s):  
Nuclear Receptor ◽  
Receptor Binding ◽  
Binding Sites

Analysis of multiple nuclear receptor binding sites for CAR/RXR in the phenobarbital responsive unit of CYP2B2

2006 ◽  
Vol 451 (2) ◽  
pp. 119-127 ◽  
Author(s):  
Quanyuan Zhang ◽  
Yangjin Bae ◽  
Jongsook Kim Kemper ◽  
Byron Kemper
Keyword(s):  
Nuclear Receptor ◽  
Receptor Binding ◽  
Binding Sites

Characterization of adenosine A1-receptor binding sites in bovine retinal membranes

1991 ◽  
Vol 53 (3) ◽  
pp. 325-331 ◽  
Author(s):  
Cynthia L. Woods ◽  
Christine Blazynski
Keyword(s):  
Receptor Binding ◽  
Binding Sites ◽  
Adenosine A1 Receptor ◽  
Adenosine A1 ◽  
A1 Receptor

scholarly journals Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP.

1994 ◽  
Vol 269 (44) ◽  
pp. 27186-27192
Author(s):  
P A Staubs ◽  
D R Reichart ◽  
A R Saltiel ◽  
K L Milarski ◽  
H Maegawa ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Receptor Binding ◽  
Binding Sites ◽  
Sh2 Domain ◽  
Insulin Receptor Binding

scholarly journals Androgen and glucocorticoid receptor direct distinct transcriptional programs by receptor-specific and shared DNA binding sites

2021 ◽  
Vol 49 (7) ◽  
pp. 3856-3875
Author(s):  
Marina Kulik ◽  
Melissa Bothe ◽  
Gözde Kibar ◽  
Alisa Fuchs ◽  
Stefanie Schöne ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Transcription Factor ◽  
Dna Binding ◽  
Receptor Binding ◽  
Binding Sites ◽  
Specific Gene ◽  
Functional Diversification ◽  
Enhancer Activity ◽  
Sequence Composition

Abstract The glucocorticoid (GR) and androgen (AR) receptors execute unique functions in vivo, yet have nearly identical DNA binding specificities. To identify mechanisms that facilitate functional diversification among these transcription factor paralogs, we studied them in an equivalent cellular context. Analysis of chromatin and sequence suggest that divergent binding, and corresponding gene regulation, are driven by different abilities of AR and GR to interact with relatively inaccessible chromatin. Divergent genomic binding patterns can also be the result of subtle differences in DNA binding preference between AR and GR. Furthermore, the sequence composition of large regions (&gt;10 kb) surrounding selectively occupied binding sites differs significantly, indicating a role for the sequence environment in guiding AR and GR to distinct binding sites. The comparison of binding sites that are shared shows that the specificity paradox can also be resolved by differences in the events that occur downstream of receptor binding. Specifically, shared binding sites display receptor-specific enhancer activity, cofactor recruitment and changes in histone modifications. Genomic deletion of shared binding sites demonstrates their contribution to directing receptor-specific gene regulation. Together, these data suggest that differences in genomic occupancy as well as divergence in the events that occur downstream of receptor binding direct functional diversification among transcription factor paralogs.

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