insulin receptor binding
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scholarly journals Glycogen synthase kinase 3β inhibition and Insulin-Receptor binding enhancement of compounds isolated from Wild Leafy Vegetable Acalypha alnifolia

2022 ◽  
pp. 100216
Author(s):  
Revathi Ponnusamy ◽  
Kalaiarasi Giriraj ◽  
Magesh Selvakumar ◽  
Parimelazhagan Thangaraj ◽  
Saikumar Sathyanarayanan ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Receptor Binding ◽  
Glycogen Synthase ◽  
Leafy Vegetable ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β ◽  
Insulin Receptor Binding

scholarly journals Increased insulin receptor binding and increased IGF-1 receptor binding are linked with increased growth of L6hIR cell xenografts in vivo

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Henning Hvid ◽  
Tine Glendorf ◽  
Jakob Brandt ◽  
Rita Slaaby ◽  
Anne Lützen ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Receptor Binding ◽  
Insulin Receptor Binding

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

2016 ◽  
Vol 23 (10) ◽  
pp. 916-920 ◽  
Author(s):  
John G Menting ◽  
Joanna Gajewiak ◽  
Christopher A MacRaild ◽  
Danny Hung-Chieh Chou ◽  
Maria M Disotuar ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Human Insulin ◽  
Receptor Binding ◽  
Binding Motif ◽  
Insulin Receptor Binding ◽  
Human Insulin Receptor

Identification of the bioactive and consensus peptide motif from Momordica charantia insulin receptor-binding protein

2016 ◽  
Vol 204 ◽  
pp. 298-305 ◽  
Author(s):  
Hsin-Yi Lo ◽  
Chia-Cheng Li ◽  
Tin-Yun Ho ◽  
Chien-Yun Hsiang
Keyword(s):  
Insulin Receptor ◽  
Receptor Binding ◽  
Binding Protein ◽  
Momordica Charantia ◽  
Peptide Motif ◽  
Insulin Receptor Binding ◽  
Consensus Peptide ◽  
Receptor Binding Protein

Placental expression of the insulin receptor binding protein GRB10: Relation to human fetoplacental growth and fetal gender

Placenta ◽  
2015 ◽  
Vol 36 (11) ◽  
pp. 1225-1230 ◽  
Author(s):  
A. Mukhopadhyay ◽  
G. Ravikumar ◽  
P. Dwarkanath ◽  
H. Meraaj ◽  
A. Thomas ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Receptor Binding ◽  
Binding Protein ◽  
Fetal Gender ◽  
Insulin Receptor Binding ◽  
Receptor Binding Protein

Insulin/receptor binding: The last piece of the puzzle?

BioEssays ◽  
2015 ◽  
Vol 37 (4) ◽  
pp. 389-397 ◽  
Author(s):  
Pierre De Meyts
Keyword(s):  
Insulin Receptor ◽  
Receptor Binding ◽  
Insulin Receptor Binding

scholarly journals Insulin receptor binding motif tagged with IgG4 Fc (Yiminsu) works as an insulin sensitizer to activate Akt signaling in hepatocytes

2015 ◽  
Vol 14 (3) ◽  
pp. 8819-8828 ◽  
Author(s):  
J. Wang ◽  
T. Zou ◽  
H.X. Yang ◽  
Y.Z. Gong ◽  
X.J. Xie ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Receptor Binding ◽  
Akt Signaling ◽  
Binding Motif ◽  
Insulin Sensitizer ◽  
Insulin Receptor Binding

scholarly journals Improved Glucose Metabolism In Vitro and In Vivo by an Allosteric Monoclonal Antibody That Increases Insulin Receptor Binding Affinity

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e88684 ◽  
Author(s):  
John A. Corbin ◽  
Vinay Bhaskar ◽  
Ira D. Goldfine ◽  
Daniel H. Bedinger ◽  
Angela Lau ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Glucose Metabolism ◽  
Insulin Receptor ◽  
Binding Affinity ◽  
Receptor Binding ◽  
Receptor Binding Affinity ◽  
Insulin Receptor Binding

scholarly journals Rat Strain Differences in Susceptibility to Alcohol-Induced Chronic Liver Injury and Hepatic Insulin Resistance

2010 ◽  
Vol 2010 ◽  
pp. 1-16 ◽  
Author(s):  
Sarah M. DeNucci ◽  
Ming Tong ◽  
Lisa Longato ◽  
Margot Lawton ◽  
Mashiko Setshedi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Liver Injury ◽  
Insulin Receptor ◽  
Inflammatory Cytokines ◽  
Receptor Binding ◽  
Hepatic Insulin Resistance ◽  
Cytokine Activation ◽  
Gapdh Expression ◽  
Insulin Receptor Binding ◽  
Pro Inflammatory Cytokines

The finding of more severe steatohepatitis in alcohol fed Long Evans (LE) compared with Sprague Dawley (SD) and Fisher 344 (FS) rats prompted us to determine whether host factors related to alcohol metabolism, inflammation, and insulin/IGF signaling predict proneness to alcohol-mediated liver injury. Adult FS, SD, and LE rats were fed liquid diets containing 0% or 37% (calories) ethanol for 8 weeks. Among controls, LE rats had significantly higher ALT and reduced GAPDH relative to SD and FS rats. Among ethanol-fed rats, despite similar blood alcohol levels, LE rats had more pronounced steatohepatitis and fibrosis, higher levels of ALT, DNA damage, pro-inflammatory cytokines, ADH, ALDH, catalase, GFAP, desmin, and collagen expression, and reduced insulin receptor binding relative to FS rats. Ethanol-exposed SD rats had intermediate degrees of steatohepatitis, increased ALT, ADH and profibrogenesis gene expression, and suppressed insulin receptor binding and GAPDH expression, while pro-inflammatory cytokines were similarly increased as in LE rats. Ethanol feeding in FS rats only reduced IL-6, ALDH1–3, CYP2E1, and GAPDH expression in liver. In conclusion, susceptibility to chronic steatohepatitis may be driven by factors related to efficiency of ethanol metabolism and degree to which ethanol exposure causes hepatic insulin resistance and cytokine activation.

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